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Caffeine in our body. What consequences?

Кофеин в нашем теле. Какие последствия?

Caffeine (also matinein, guaranine) is a pseudo- alkaloid of the purine series, colorless or white bitter crystals. It is a psychostimulant found in coffee, tea and many soft drinks. Caffeine is found in plants such as coffee tree, tea, cocoa, mate, guarana, cola, and some others. It is synthesized by plants to protect against insects that eat leaves, stems and grains, as well as to encourage pollinators.

How many times have I heard the phrase "I can’t do without coffee!" Well what can I say? “You have big problems, friends.” We read below and UNDERSTAND;)

In animals and humans, it stimulates the central nervous system, enhances cardiac activity, accelerates the pulse, causes the expansion of blood vessels (mainly vessels of the skeletal muscles, brain, heart, kidneys), enhances urination, reduces platelet aggregation. This is due to the fact that caffeine blocks the enzyme phosphodiesterase, which destroys cAMP, which leads to its accumulation in cells. cAMP is a secondary mediator through which the effects of various physiologically active substances, primarily adrenaline, are realized. Thus, the accumulation of cAMP leads to adrenaline-like effects.

In medicine, caffeine is used in the treatment of headaches, with migraines, as a stimulant of respiration and cardiac activity in colds, to increase mental and physical performance, to eliminate drowsiness. Dosages for the appointment of caffeine should be selected individually. Higher doses for adults inside: single 0.3 g daily 1.0 g, intravenous single 0.4 g daily 1 g

Caffeine is on the list of vital and essential drugs.

Discovery story

It was discovered and named “caffeine” in 1819 by the German chemist Ferdinand Runge.

In 1827, Udry isolated a new alkaloid from tea leaves and called it thein. Pure caffeine was first obtained in 1828 (Pelletier and Cavantou). In 1832, its composition was established by Weller and Pfaff and Liebig. In 1838, Jobst and G. Ya. Mulder proved the identity of thein and caffeine.

The structure of caffeine was clarified by the end of the 19th century by German Emil Fischer, who was also the first person to artificially synthesize caffeine. He won the 1902 Nobel Prize in Chemistry, which he received in part because of this work.

Chemical structure and properties

The chemical name for caffeine is 1,3,7-trimethyl-xanthine. In an alkaline environment (at pH> 9), C7H12N4O is converted to caffeine. In structure and pharmacological properties, caffeine is close to theobromine and theophylline; all three alkaloids belong to the group of methylxanthines. Caffeine acts better on the central nervous system, and theophylline and theobromine - as stimulants of cardiac activity and lung diuretics.

Caffeine, like other purine alkaloids, gives a positive murexide reaction; when heated with Nessler's reagent, caffeine forms a red-brown precipitate, unlike theobromine, which gives a light brown color in such conditions.

Physical properties

White needle crystals of bitter taste, odorless. It is soluble in chloroform, poorly soluble in cold water (1:60), easy in hot (1: 2), hardly soluble in ethanol (1:50). Solutions have a neutral reaction; sterilized at + 100C for 30 minutes T pl. 234C

Кофеин в нашем теле. Какие последствия?

As soon as caffeine enters the bloodstream, our body receives a signal of attack. He introduces a state of emergency and carries out general mobilization for his defense. The pupils dilate to better see the threat, the pulse increases and blood pressure rises to better supply blood to the muscles. Mobilizing all the forces to protect itself and striving to increase the blood supply to the muscles, the body assigns a secondary role to the digestive system and transfers it to the “dependent ration”. Therefore, coffee lovers often have digestive problems.

The liver, switching to the "fight or run" mode (the body's reaction to stress), saturates the blood with sugar and fats. Caffeine stimulates the nervous system of the adrenal glands, bringing the body into a state of complete “combat readiness”.

And you thought that coffee gives you strength! A person’s body cannot often be in such an increased degree of stress without serious health consequences, such as heart attacks and a hypertensive crisis. For such a caffeine “explosion” your body pays too much. In the morning you feel lethargic and lethargic. You need to have a cup of coffee again, and the vicious circle closes again.

“Using stimulants is like pushing a horse. They act for a short time, but with constant use they lead to disastrous consequences. ” Stephen Cherniski, Coffee Blues.

Many people use coffee to stimulate bowel movement. Coffee acts as a laxative on an empty stomach. However, it is not coffee that stimulates bowel movements. A cup of hot water with lemon and natural honey will have exactly the same effect. In fact, coffee consumption, on the contrary, often leads to constipation. Caffeine draws water from the digestive tract, making stool harder.

And any food eaten after a cup of coffee will not be completely digested and assimilated, because the blood supply to the digestive tract is weakened.

Caffeine exacerbates many problems, such as dry skin, itching, and hand tremors. Like nicotine and alcohol, caffeine is a vasoconstrictor that impairs the skin’s moisture and blood supply. Enhancing dehydration, caffeine accelerates the aging process. And this means the premature appearance of wrinkles and wrinkles on the skin and a decrease in metabolic efficiency.

There is also a lot of evidence that after drinking a cup of coffee, nutrients are excreted from the body with urine.

Caffeine leads to the loss of thiamine and other B vitamins, which provokes disturbances in the body's nutrition. It reduces the absorption of iron and can cause a deficiency in the body. The phosphoric acid in coffee makes it difficult to absorb calcium. Research data suggests an increased risk of fractures in women who use caffeine. And if caffeine is mixed with sugar, then the body’s loss of minerals even increases.

You drink a cup of coffee, and after two hours the calcium, magnesium and potassium so needed by the body are in your urine! Where did they come from there? Of course, not from the coffee you drank!

Caffeine detoxification is performed by the liver, which creates an additional excessive load for it.

Caffeine is a psychotropic drug, the same as morphine, nicotine and cocaine. The ascent you experience while taking it has a cumulative effect and is quickly addictive.

Caffeine can cause DNA and RNA replication errors, which in turn leads to a malfunction in the transfer of biological information.

Coffee interferes with sound sleep, and that may be why in order to recover in the morning, you need another dose of this drink. Coffee contains not only caffeine, but also a large amount of toxic chemicals. Some of them are carcinogens.