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- from pyrazolone derivatives, was introduced into therapy first (1884, amidopyrine synthesized three years later). It has a moderate anti-inflammatory effect, less active than amidopyrine, analgin, especially butadione. Applied inside with neuralgia, rheumatism, colds, the dose of adults is 0.25-0.5 g per reception, 2-3 times a day. When applied topically, it also has some hemostatic effect: 1020% solution for wetting tampons during nosebleed.