- limited presenile atrophy of the brain, mainly in the frontal and temporal lobes. The disease begins at 50-55 years, lasts 5-10 years, leading to total dementia. Perhaps an earlier and later start. Women get sick more often than men. Illness begins with personality changes. Appears lethargy, apathy, the initiative disappears, the liveliness of emotional reactions disappears. The productivity of thinking decreases, the ability for abstraction, generalization and reflection is disturbed, the criticism of one's state, behavior, and self-indignation disappears. In some patients, there is euphoria with disinhibition of instincts and loss of moral and moral attitudes. Speech becomes poor, with a progressive decrease in vocabulary, stereotypical repetitions of the same words, phrases. There are gross violations of the letter: changing handwriting, literacy, semantic expression. The patient gradually ceases to recognize objects, to understand their purpose (for example, they cannot name a pen, a knife, and what they are for), and therefore cannot use them. A deep decrease in intelligence leads to increased suggestibility and stereotypical imitation of others (their facial expressions, gestures, repetition of words). If the patient is not disturbed, then he is mostly silent, or repeats the same movements or phrases.
With the development of the disease, memory impairments are becoming more and more noticeable, especially the memorization of new information, leading to a violation of orientation in space. In the final stage, a total disintegration of thinking, recognition, speech, writing, skills occurs. There comes complete mental and physical helplessness (marasmus). The prognosis is unfavorable. Death comes from various causes, usually as a result of the addition of an infection.