Description of the medicine: Fluorotan (Phthorothanum)
FLUOROTANE (Phthorothanum). 1, 1, 1-Trifluoro-2-chloro-2-bromoethane.
Synonyms: Halotan, Narcotan, Fluotan, Anestan, Fluctan, Fluothane, Ftorotan, Halan, Halothane, Halothanum, Narcotan, Rhodialotan, Somnothane.
Colorless, transparent, mobile, easily volatile liquid with a smell resembling the smell of chloroform, sweet and burning taste. Density 1.865 - 1.870. Boiling point (distillation) + 49 - 51 С. It is slightly soluble in water (0.345%), miscible with anhydrous alcohol, ether, chloroform, trichlorethylene, oils. The oil / water distribution coefficient is 330. The vapor pressure at + 20 C is 241.5 mm Hg. Art.
Fluorotan does not burn or ignite. Its vapors, mixed with oxygen and nitrous oxide in the ratios used for anesthesia, are explosion-proof, which is its valuable property when used in a modern operating room.
Under the influence of light, fluorotan slowly decomposes, so it is stored in orange glass bottles; thymol (0.01%) is added for stabilization.
Fluorotan is a powerful narcotic that allows you to use it yourself (with oxygen or air) to achieve the surgical stage of anesthesia or as a component of combined anesthesia in combination with other narcotic drugs, mainly nitrous oxide.
Pharmacokinetically, fluorotan is characterized by easy absorption from the respiratory tract and rapid release by the lungs unchanged; only a small portion of fluorotan is metabolized in the body. The drug has a rapid narcotic effect, stopping shortly after the end of inhalation.
For introduction into anesthesia, they begin with the supply of fluorotan at a concentration of 0.5 vol. % (with oxygen), then within 1, 5 - 3 min increase it to 3-4 vol. % To maintain the surgical stage of anesthesia, a concentration of 0.5 - 2 vol. %
When using fluorotan, consciousness usually turns off after 1-2 minutes after the start of inhalation of its vapor. After 3-5 minutes, the surgical stage of anesthesia sets in. After 3 to 5 minutes after the cessation of fluorotan, patients begin to awaken. Anesthetic depression completely disappears after 5 to 10 minutes after short-term and 30 to 40 minutes after prolonged anesthesia. Excitation is rare and mild.
Vapor fluorotan does not cause mucosal irritation. There are no significant changes in gas exchange during anesthesia with fluorotane; blood pressure usually decreases, which is partially associated with the inhibitory effect of the drug on the sympathetic ganglia and with the expansion of peripheral vessels. The vagus nerve tone remains high, which creates conditions for bradycardia. To some extent, fluorotan has a deprimative effect on the myocardium. In addition, fluorotan increases myocardial sensitivity to catecholamines: administration of adrenaline and norepinephrine during anesthesia can cause ventricular fibrillation.
Fluorotan does not affect kidney function; in some cases, there may be impaired liver function with the appearance of jaundice.