Medication Description: Fluorotane (Phthorothanum)
Fluoro (Phthorothanum). 1, 1, 1-Trifluoro-2-chloro-2-bromoethane.
Synonyms: Halothane, Narcotan, Fluotan, Anestan, Fluctan, Fluothane, Ftorotan, Halan, Halothane, Halothanum, Narcotan, Rhodialotan, Somnothane.
Colorless, transparent, mobile, easily volatile liquid with a smell resembling the smell of chloroform, sweet and pungent taste. Density is 1,865 - 1,870. Boiling point (distillation) + 49 - 51 C. Soluble in water (0.345%), miscible with anhydrous alcohol, ether, chloroform, trichlorethylene, oils. The distribution coefficient of oil / water 330. The vapor pressure at a temperature of + 20 C is 241, 5 mm Hg. Art.
Fluorotane does not burn or ignite. His vapors in a mixture with oxygen and nitrous oxide in the ratios used for anesthesia, are explosion-proof, which is a valuable property when used in the conditions of a modern operating room.
Under the action of light, halothane slowly decomposes, so it is stored in orange glass flasks; Thymol (0.01%) is added to stabilize.
Ftorotan is a powerful drug that allows you to use it yourself (with oxygen or air) to achieve the surgical stage of anesthesia or as a component of combined anesthesia in combination with other drugs, mainly with nitrous oxide.
Pharmacokinetic ftorotan differs easy absorption from the respiratory tract and the rapid release of the lungs unchanged; only a small part of ftorotana is metabolized in the body. The drug has a rapid narcotic effect, ending soon after the end of inhalation.
For the introduction of anesthesia start with the supply of ftorotana at a concentration of 0.5 vol. % (with oxygen), then for 1, 5 - 3 min increase it to 3 - 4 about. % To maintain the surgical stage of anesthesia apply a concentration of 0.5 - 2 vol. %
When using ftorotana, consciousness is usually turned off after 1-2 minutes after the start of inhalation of its vapor. After 3-5 minutes, the surgical stage of anesthesia begins. After 3 to 5 minutes after stopping the supply of ftorotan, patients begin to wake up. Anesthetic depression completely disappears after 5–10 minutes after a short-term and 30–40 minutes after a long anesthetic. Excitement is rare and mild.
Vapor of a ftorotan not cause irritation of the mucous membranes. Significant changes in gas exchange during anesthesia with ftorotan does not occur; blood pressure usually decreases, which is partly due to the depressant effect of the drug on the sympathetic ganglia and to the expansion of peripheral vessels. The vagal nerve tone remains high, which creates conditions for bradycardia. To some extent, ftorotan has a depriving effect on the myocardium. In addition, ftorotan increases myocardial sensitivity to catecholamines: the introduction of epinephrine and norepinephrine during anesthesia can cause ventricular fibrillation.
Halothane does not affect kidney function; in some cases, possible abnormal liver function with the appearance of jaundice.