Description of the medicine: Amitriptyline (Amitriptylinum)
AMITRIPTILINE (Amitriptylinum). 5- (3-Dimethylaminopropylidene) -10,11-dihydrodibenzocycloheptene.
Available in the form of hydrochloride (Amitriptylini hydrochloridum):
Synonyms: Teperin, Triptisol, Amitriptyline, Adepril, Adepress, Amiprin, Atryptal, Damilen, Daprimen, Elatral, Elavil, Lantron, Laroxal, Laroxyl, Lentizol, Novotriptyn, Proheptadien, Redomex, Saroten, Sarriptol, Teotriptol, Terotript, Terotript, Terotript, Terotript, Terotript, Terotript, Teotript Tryptanol, Tryptizol et al.
Amitriptyline, like imipramine, is one of the main representatives of tricyclic antidepressants. In structure, it differs from imipramine in that the nitrogen atom in the central part of the tricyclic system is replaced by a carbon atom.
It is an inhibitor of neuronal reuptake of mediator monoamines, including norepinephrine, dopamine, serotonin, etc. It does not cause MAO inhibition.
Significant cholinolytic activity is characteristic.
The timoleptic effect is combined in amitriptyline with a pronounced sedative effect.
It is mainly used for endogenous depression. It is especially effective in anxiety-depressive states; reduces anxiety, agitation and actually depressive manifestations.
It does not cause exacerbation of delirium, hallucinations and other productive symptoms, which is possible with the use of antidepressant stimulants (imipramine, etc.).
Assign inside, intramuscularly or into a vein. Inside take (after eating), starting from 0.05 - 0.075 g (50 - 75 mg) per day, then the dose is gradually increased by 0.025 - 0.05 g to obtain the desired antidepressant effect. The average daily dose is 0.15 - 0.25 g (150 - 250 mg) for 3 to 4 doses (during the day and at bedtime). Upon reaching a lasting effect, the dose is gradually reduced. In severe depression, up to 300 mg (or more) is prescribed per day.
In severe depression, you can start with the introduction of the drug intramuscularly or intravenously (inject slowly!) At a dose of 0.02-0.04 g (20-40 mg) 3-4 times a day. Injections are gradually replaced by ingestion of the drug.
In elderly patients, the drug is prescribed in smaller doses; children are reduced doses in accordance with age.
Amitriptyline is relatively widely used in somatic medicine for depressive and neurotic conditions. Assign inside in relatively small doses (0.0125 - 0.00625 g = 1/2 - 1/4 tablets).
Amitriptyline is usually well tolerated. Due to the presence of a sedative effect, it does not disturb sleep, and it is prescribed throughout the day, including at bedtime. However, due to the pronounced cholinolytic effect when taking amitriptyline, dry mouth, dilated pupils, accommodation disturbance, urinary retention, and drowsiness, dizziness, hand tremor, paresthesia, allergic reactions, and heart rhythm disturbances can be observed.
Amitriptyline as a drug with pronounced anticholinergic activity is contraindicated in glaucoma, prostatic hypertrophy, atony of the bladder. It should not be prescribed concurrently with monoamine oxidase inhibitors.
Method of release: tablets of 0.025 g (25 mg); 1% solution in ampoules of 2 ml (20 mg).
Storage: List B.