Medication Description: Amitriptyline (Amitriptylinum)
AMITRIPTILIN (Amitriptylinum). 5- (3-Dimethylaminopropylidene) -10,11-dihydrodibenzocyclohepten.
Available as hydrochloride (Amitriptylini hydrochloridum):
Synonyms: Teperin, Triptizol, Amitriptyline, Adepril, Adepress, Amiprin, Atryptochal, Damilen, Daprimen, Elatral, Elavil, Lantron, Laroxal, Laroxyl, Lentizol, Novotriptyn, Proheptadien, Redomex, Saroten, Sarotexxxxxx, Novotriptyn, Proheptadien, Redomex, Saroten, Sarotexxxxxxx, Novotriptyn Tryptanol, Tryptizol and others.
Amitriptyline, like imipramine, is one of the main representatives of tricyclic antidepressants. The structure differs from imipramine in that the nitrogen atom in the central part of the tricyclic system is replaced by a carbon atom.
It is an inhibitor of reverse neuronal seizure of mediator monoamines, including norepinephrine, dopamine, serotonin, and others. MAO does not cause inhibition.
Characterized by significant anticholinergic activity.
Thymoleptic action is combined in amitriptyline with a pronounced sedative effect.
Apply mainly for endogenous depressions. Especially effective in anxiety-depressive states; reduces anxiety, agitation and actually depressive manifestations.
Does not cause exacerbation of delusions, hallucinations and other productive symptoms, which is possible with the use of antidepressants, stimulants (imipramine, etc.).
Assign inside, intramuscularly or into a vein. Inside take (after eating), ranging from 0.05 - 0.05 g (50 - 75 mg) per day, then the dose is gradually increased by 0.025 - 0.05 g to obtain the desired antidepressant effect. The average daily dose is 0.15-0.25 g (150-250 mg) for 3 to 4 doses (during the day and before bedtime). Upon reaching a stable effect, the dose is gradually reduced. For severe depressions, up to 300 mg (or more) is prescribed per day.
In severe depressions, you can begin with the introduction of the drug intramuscularly or intravenously (inject slowly!) At a dose of 0.02–0.04 g (20–40 mg) 3–4 times a day. Injections are gradually replaced by taking the drug inside.
Elderly patients drug is prescribed in smaller doses; children reduce the dose in accordance with age.
Amitriptyline is relatively widely used in somatic medicine for depressive and neurotic states. Assign inside in relatively small doses (0.0125 - 0.00625 g = 1/2 - 1/4 tablet).
Amitriptyline is usually well tolerated. Due to the presence of sedation does not disrupt sleep, and it is prescribed throughout the day, including at bedtime. However, due to the pronounced anticholinergic effect, when taking amitriptyline, dry mouth, dilated pupils, accommodation disturbance, urinary retention, as well as drowsiness, dizziness, hand tremor, paresthesia, allergic reactions, and heart rhythm disturbances can be observed.
Amitriptyline as a drug with pronounced anticholinergic activity is contraindicated in glaucoma, prostatic hypertrophy, and atony of the bladder. It should not be administered simultaneously with monoamine oxidase inhibitors.
Method of production: tablets of 0.025 g (25 mg); 1% solution in ampoules of 2 ml (20 mg).
Storage: List B.