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Description of the medicine: Methyluracil (Methyluracilum)

METHYLURACIL (Methyluracilum). 2, 4-dioxo-6-methyl-1, 2, 3, 4-tetrahydropyrimidine.

Synonym: Metacil.

Flavourless white crystalline powder.

Slightly soluble in water (up to 0.9% at a temperature of + 20 ° C) and alcohol. Aqueous solutions (pH 7, 0) are sterilized at a temperature of + 100 ° C for 30 minutes.

By the chemical structure, methyluracil is a pyrimidine derivative. According to experimental data, a number of drugs of this group (methyluracil, pentoxyl, etc.) have anabolic and anti-catabolic activity. These drugs accelerate cell regeneration processes; accelerate wound healing, stimulate cellular and humoral defense factors. They also have anti-inflammatory effects. A characteristic feature of compounds of this series is the stimulation of erythro- and especially leukopoiesis, in connection with which they are usually assigned to the group of leukopoiesis stimulants.

As a stimulant of leukopoiesis, methyluracil is prescribed for agranulocytic tonsillitis, nutritional toxic aleukia, chronic benzene poisoning, leukopenia as a result of chemotherapy for malignant neoplasms, with x-ray and radiotherapy, and other conditions accompanied by leukopenia.

It should be borne in mind that methyluracil, like other leukopoiesis stimulants, is advisable to use in mild forms of leukopenia. In cases of moderate severity, the use of hematopoietic stimulants is indicated only in the case of renewal of impaired blood cell regeneration; with severe lesions of the hematopoietic system, methyluracil is not used.

It is also prescribed for sluggishly healing wounds, burns, bone fractures.

There is evidence of the effectiveness of methyluracil in gastric and duodenal ulcers and chronic gastritis. It is believed that the therapeutic effect is associated with the normalization of nucleic acid metabolism in the mucous membrane. They are also used for hepatitis, pancreatitis.

Take methyluracil orally during or after meals. Adults are given 0.5 g 4 times a day (if necessary, up to 6 times a day); children aged 3 to 8 years - 0.25 g; over 8 years old - 0.25 - 0.5 g 3 times a day.

The course of treatment for diseases of the gastrointestinal tract usually lasts 30 to 40 days, in other cases it may be less long.

For local injuries (skin lesions, proctitis, sigmoiditis, etc.) that occur during radiation therapy, it is prescribed orally and topically.

Locally for wounds, burns, trophic ulcers, 10% methyluracil ointment is used. For the treatment of rectitis, sigmoiditis, ulcerative colitis, suppositories containing methyluracil are used (1 to 4 suppositories per day for an adult). Microclysters can also be used (0.2 - 0.4 g of methyluracil on starch paste in a volume of 20 - 25 ml). Methyluracil has no local irritant effect on tissues.

There are indications that methyluracil in the form of an ointment (5%) and cream has a photoprotective effect in patients with photodermatosis.