Medication Description: Methyluracil (Methyluracilum)
Methyluracil (Methyluracilum). 2, 4-dioxo-6-methyl-1, 2, 3, 4-tetrahydropyrimidine.
White crystalline powder; odorless.
It is soluble in water (up to 0.9% at a temperature of + 20 'C) and alcohol. Aqueous solutions (pH 7.0) are sterilized at a temperature of + 100 ° C for 30 minutes.
By chemical structure, methyluracil refers to pyrimidine derivatives. According to experimental data, a number of drugs in this group (methyluracil, pentoxyl, etc.) have anabolic and anti-catabolic activity. These drugs accelerate cell regeneration processes; accelerate wound healing, stimulate cellular and humoral protection factors. They also have anti-inflammatory effects. A characteristic feature of the compounds of this series is the stimulation of erythro-and especially leukopoiesis, in connection with which they are usually referred to the group of stimulants of leukopoiesis.
As a stimulator of leukopoiesis, methyluracil is prescribed for agranulocytic angina, alimentary-toxic aleukia, chronic benzene poisoning, leukopenia as a result of chemotherapy of malignant tumors, with X-ray and radiotherapy, and other conditions accompanied by leukopenia.
It should be borne in mind that methyluracil, like other stimulants of leukopoiesis, it is advisable to use in mild forms of leukopenia. In case of moderate lesions, the use of hematopoietic stimulants is indicated only in the case of renewals of impaired regeneration of blood cells; in severe lesions of the hematopoietic system, methyluracil is not used.
It is also prescribed for sluggish healing wounds, burns, and bone fractures.
There is evidence of the effectiveness of methyluracil in gastric ulcer and duodenal ulcer and chronic gastritis. It is believed that the therapeutic effect is associated with the normalization of nucleic acid metabolism in the mucosa. Applied also with hepatitis, pancreatitis.
Methyluracil is taken orally during or after a meal. Adults give 0.5 g 4 times a day (if necessary up to 6 times a day); children aged 3 to 8 years old - at 0.25 g, over 8 years old - at 0.25 - 0.5 g 3 times a day.
The course of treatment for diseases of the gastrointestinal tract usually lasts 30 - 40 days, in other cases it may be less long.
For local lesions (skin lesions, proctitis, sigmoiditis, etc.) that occur during radiation therapy, it is administered orally and topically.
Locally for wounds, burns, trophic ulcers apply 10% methyluracil ointment. For the treatment of rectitis, sigmoiditis, ulcerative colitis used candles containing methyluracil (1 to 4 candles per day per adult). Microclysters can also be used (0.2-0.4 g of methyluracil on starch paste in a volume of 20-25 ml). Methyluracil has no local irritating effect on tissue.
There are indications that methyluracil as an ointment (5%) and cream has a photoprotective effect in patients with photodermatosis.