Description of the medicine: Methyluracilum (Methyluracilum)

METHYLURACILE (Methyluracilum). 2, 4-Dioxo-6-methyl-1,2,3,4-tetrahydro-pyrimidine.

Synonym: Metacil.

White crystalline powder odorless.

It is slightly soluble in water (up to 0.9% at a temperature of + 20 ° C) and alcohol. Aqueous solutions (pH 7, 0) are sterilized at a temperature of + 100 ° C for 30 minutes.

According to its chemical structure, methyluracil belongs to pyrimidine derivatives. According to experimental data, a number of drugs of this group (methyluracil, pentoxyl, etc.) has anabolic and anti-catabolic activity. These drugs accelerate the processes of cellular regeneration; Accelerate wound healing, stimulate cellular and humoral defense factors. They also have an anti-inflammatory effect. A characteristic feature of the compounds of this series is the stimulation of erythro- and especially leukopoiesis, which is why they are usually referred to as a group of leukopoiesis stimulants.

As a stimulant of leukopoiesis, methyluracil is prescribed for agranulocyte angina, alimentary-toxic aleukia, chronic benzene poisoning, leukopenia as a result of chemotherapy of malignant neoplasms, with X-ray and radiotherapy, and other conditions accompanied by leukopenia.

It should be noted that methyluracil, like other stimulants of leukopoiesis, is advisable to use in mild forms of leukopenia. For lesions of moderate severity, the use of hemopoietic stimulants is indicated only in the case of renewed impaired regeneration of blood cells; With severe lesions of the hematopoietic system, methyluracil is not used.

Assign also with sluggishly healing wounds, burns, fractures of bones.

There are data on the efficacy of methyluracil in peptic ulcer of the stomach and duodenum and chronic gastritis. It is believed that the therapeutic effect is related to the normalization of the nucleic acid metabolism in the mucosa. They are also used for hepatitis, pancreatitis.

Take methyluracil inside during or after a meal. Adults give 0.5 grams 4 times a day (if necessary up to 6 times a day); Children aged 3 to 8 years - 0.25 g, over 8 years - 0.25 - 0.5 g 3 times a day.

The course of treatment for diseases of the gastrointestinal tract lasts usually 30 to 40 days, in other cases may be less prolonged.

With local injuries (skin lesions, proctitis, sigmoiditis, etc.), arising from radiation therapy, appoints inside and locally.

Locally with wounds, burns, trophic ulcers apply 10% methyluracil ointment. To treat rections, sigmoiditis, ulcerative colitis candles containing methyluracil (1 to 4 suppositories per day for adults) are used. Microclysters (0.2-0.4 g of methyluracil on a starch paste in a volume of 20-25 ml) can also be used. Local irritant effect on tissue methyluracil does not.

There are indications that methyluracil in the form of ointment (5%) and cream has a photoprotective effect in patients with photodermatoses.