Medication Description: Potassium Orota (Kalii orotas)
POTASSIUM OROTAT (Kalii orotas).
Potassium salt of uracil-4-carboxylic (orotic) acid.
Synonyms: Dioron, Kalium oroticum, Orocid, Oropur.
White crystalline powder. Very little soluble in water.
Orotic acid is one of the precursors of the pyrimidine nucleotides that make up the nucleic acids that are involved in the synthesis of protein molecules. Orotic acid and its salts are therefore considered as a substance of anabolic action and are used for disorders of protein metabolism, as general stimulants of metabolic processes.
The potassium salt of orotic acid (potassium orotate) is usually used.
Potassium orotate is prescribed in combination with other drugs (vitamins, etc.) for liver diseases (with the exception of cirrhosis of the liver with ascites) caused by acute and chronic intoxications, myocardial dystrophy, alimentary and alimentary-infectious dystrophy in children and with other indications when It is advisable to stimulate anabolic processes. There is evidence of the use of potassium orotate for the treatment of progressive muscular dystrophy. Sometimes the drug is used for arrhythmias (especially extrasystoles and atrial fibrillation); the effect of the drug is explained in these cases by the presence of potassium ion in the preparation (see Potassium chloride), but the content of potassium in the preparation is small (20%).
Potassium orotate is also used to improve anabolic processes during strenuous exercise.
Accept inside (for 1 h before food or in 4 h after it). Dose for adults from 0.5 to 1, 5 g per day (0.25 - 0.3 g 2 - 3 times a day).
The course of treatment is 20-40 days, and in some cases longer. If necessary, repeat the course of treatment after a month's break. In some cases, depending on the effectiveness and tolerability, the daily dose for adults is increased to 3 g.
Children (with alimentary and alimentary-infectious hypotrophy, anemia, during the recovery period, etc.) are prescribed at the rate of 10-20 mg per 1 kg of body weight per day (in 2 to 3 doses). The course of treatment for 3 - 5 weeks.
The drug is usually well tolerated. In some cases, allergic dermatoses are observed, quickly passing after drug withdrawal; if necessary, prescribe antihistamines. Dyspeptic symptoms are possible.
Form release: tablets of 0.1 g (for children) and 0.5 g (for adults).
For the appointment of children also produced in the form of granules.
Storage: under normal conditions.