Description of medicine: Potassium orotat (Kalii orotas)
POTASSIUM OROTAT (Kalii orotas).
Potassium salt of uracil-4-carboxylic (orotic) acid.
Synonyms: Dioron, Kalium oroticum, Orocid, Oropur.
White crystalline powder. Very slightly soluble in water.
Orotic acid is one of the precursors of pyrimidine nucleotides that make up nucleic acids, which are involved in the synthesis of protein molecules. Orotic acid and its salts are therefore considered as a substance of anabolic action and are used for disorders of protein metabolism, as general stimulants of metabolic processes.
Usually, potassium salt of orotic acid (potassium orotate) is used.
Potassium orotate is prescribed in combination with other agents (vitamins, etc.) for liver diseases (with the exception of liver cirrhosis with ascites) caused by acute and chronic intoxications, with myocardial dystrophy, alimentary and alimentary-infectious dystrophy in children, and with other indications, when it is advisable to stimulate anabolic processes. There is evidence of the use of potassium orotate for the treatment of progressive muscular dystrophy. Sometimes the drug is used for arrhythmias (especially extrasystoles and atrial fibrillation); the effect of the drug is explained in these cases by the presence of potassium ion in the preparation (see Potassium chloride), however, the potassium content in the preparation is low (20%).
Potassium orotate is also used to improve anabolic processes during intense physical exertion.
Take orally (1 hour before meals or 4 hours after it). Dose for adults from 0.5 to 1.5 g per day (0.25 - 0.3 g 2 to 3 times a day).
The course of treatment is 20 to 40 days, and in some cases longer. If necessary, repeat the treatment after a month's break. In some cases, depending on the effectiveness and tolerability, the daily dose for adults is increased to 3 g.
Children (with alimentary and alimentary-infectious hypotrophy, anemia, during the period of convalescence, etc.) are prescribed at the rate of 10 - 20 mg per 1 kg of body weight per day (in 2 - 3 doses). The course of treatment is 3 to 5 weeks.
The drug is usually well tolerated. In some cases, allergic dermatoses are observed, quickly passing after discontinuation of the drug; if necessary, antihistamines are prescribed. Dyspeptic symptoms are possible.
Release form: tablets of 0.1 g (for children) and 0.5 g (for adults).
For use in children, it is also produced in the form of granules.
Storage: under normal conditions.