Description of the medicine: Adenosine triphosphoric acid (Acidum adenosintriphosphoricum)
Adenosine triphosphoric acid (Acidum adenosintriphosphoricum).
Adenosine-5'-triphosphoric acid, or 9-b-D-ribofuranoside triphosphoric ester.
Synonyms of the adenosine triphosphoric acid and its sodium salt: ATP, Atrifos, Miotrifos, Phosphobion, Adephos, Atrifos, Atriphos, Sortrifos, Fosfobion, Muotriphos, Striadyne, Triadenyl, Trifosfodin, Trifosyl, Triphaden, Triphaden.
Adenosine triphosphoric acid, or adenosine triphosphate (ATP), is a natural component of the tissues of the human and animal body. It is formed during oxidation reactions and in the process of glycolytic breakdown of carbohydrates. Muscles from striated smooth muscle tissue are especially rich in it. Its content in skeletal muscle reaches 0.3%.
ATP is involved in many metabolic processes. When interacting with actomyosin, it breaks down into adenosine diphosphoric acid (ADP) and inorganic phosphate, while energy is released, a significant part of which is used by muscles for mechanical work, as well as synthetic processes (synthesis of protein, urea and intermediate metabolic products). With dystrophic processes in the muscles, a decrease in its content in muscle tissue or a violation of its resynthesis processes is observed. ATP is considered as one of the mediators of excitation in adenosine (purinergic) receptors (For mediator and other properties of adenosine, see Theophylline, Cardiac Glycosides, Caffeine.). In addition, it is involved in the transmission of nervous excitation in adrenergic and cholinergic synapses, facilitates the excitation in the autonomic nodes and in the transmission of excitation from the vagus nerve to the heart. ATP is also believed to be an inhibitory mediator in the gastrointestinal tract, released by postganglionic fibers emerging from the Auerbach (intermuscular nerve) plexus, and also an exciting mediator in the tissues of the bladder.
Experimental data show that ATP enhances cerebral and coronary circulation.
For medical use, ATP is obtained from the muscle tissue of animals.
ATP is a white crystalline hygroscopic powder. For medical use, a solution of sodium adenosine triphosphate 1% for injection (Solutio Natrii adenosintriphosphatis 1% pro injectionibus) is available.
The sodium adenosine triphosphate solution is a colorless or slightly yellowish liquid; pH 7.0-7.3.
ATP was previously relatively widely used in chronic coronary insufficiency. It has been established, however, that its penetration through cell membranes requires a large amount of energy, which casts doubt on the role of ATP as an energy source to ensure myocardial contractility and improve metabolic processes in it.
The main use of sodium adenosine triphosphate is currently in the complex treatment of muscle dystrophy and atrophy, peripheral vascular spasms (intermittent claudication, Raynaud's disease, thromboangiitis obliterans).