Medication Description: Adenosine triphosphate (Acidum adenosintriphosphoricum)
Adenosine Acid Acid (Acidum adenosintriphosphoricum).
Adenosine-5'-triphosphoric acid, or 9-b -D-ribofuranoside triphosphoric ester.
Synonyms of adenosine triphosphate acid and its sodium salt: ATP, Atrifos, Myotripos, Phosphobion, Adephos, Atrifos, Atriphos, Creativerifos, Fosfobion, Mouratriphos, Striadyne, Triadenyl, Trifosfodin, Trifosyl, Triphosaden, tenthyne, Tridenyl, Trifosyl, Trifosfodin, Trifosyl, Triphosaden, Tiffosine
Adenosine triphosphate, or adenosine triphosphate (ATP), is a natural component of human and animal body tissues. It is formed during oxidation reactions and in the process of glycolytic breakdown of carbohydrates. It is especially rich in muscles from striated smooth muscle tissue. Its content in skeletal muscle reaches 0.3%.
ATP is involved in many metabolic processes. When interacting with actomyosin, it decomposes into adenosine diphosphoric acid (ADP) and inorganic phosphate, thus releasing energy, much of which is used by muscles for mechanical work, as well as synthetic processes (synthesis of protein, urea and metabolic intermediates). With dystrophic processes in muscles, a decrease in its content in muscle tissue or a violation of its resynthesis processes is observed. ATP is considered as one of the excitatory mediators in adenosine (purinergic) receptors (For mediator and other properties of adenosine, see Theophylline, Cardiac glycosides, Caffeine.). In addition, it is involved in the transmission of nervous excitement in adrenergic and cholinergic synapses, facilitates excitation in the autonomic nodes and in the transmission of excitation from the vagus nerve to the heart. ATP is also believed to be an inhibitory mediator in the gastrointestinal tract, released postganglionic fibers emanating from the Auerbach (intermuscular nerve) plexus, and also an excitatory mediator in the tissues of the bladder.
Experimental data show that ATP enhances cerebral and coronary circulation.
For medical use, ATP is derived from animal muscle tissue.
ATP is a white crystalline hygroscopic powder. For medical use, a solution of sodium adenosine triphosphate 1% for injection is produced (Solutio Natrii adenosintriphosphatis 1% of injectionibus).
The sodium solution of adenosine triphosphate is a colorless or slightly yellowish liquid; pH 7, 0-7, 3.
Previously, ATP was widely used for chronic coronary insufficiency. It has been found, however, that its penetration through cell membranes requires a large amount of energy, which casts doubt on the role of ATP as an energy source to ensure myocardial contractility and improve metabolic processes in it.
The main use of sodium adenosine triphosphate is currently in the complex therapy of muscular dystrophy and atrophy, spasms of peripheral vessels (intermittent claudication, Raynaud's disease, thromboangiitis obliterans).