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Medication Description: Riboxinum

Riboxin (Riboxinum). 9-b-D-Ribofuranosylhypoxanthin, or hypoxanthine-riboside.

Synonyms: Inosie-F, Inosin, Atorel, Inosie-F, Inosin, Inosiron-E, Inotin, Irpelen, Oxiamin, Ribonosine, Teberin, Trophicardyl, etc.

White or white with a faint yellowish tinge crystalline powder, bitter taste, odorless. Slowly and difficultly soluble in water, very slightly soluble in alcohol.

Riboxin is a derivative (nucleoside) of purine. It can be considered as a precursor of ATP. There is evidence of the ability of the drug to increase the activity of a number of Krebs cycle enzymes, stimulate the synthesis of nucleotides, have a positive effect on metabolic processes in the myocardium and improve coronary circulation. By type of action refers to anabolic substances. As a nucleoside, inosine can enter cells and increase the energy balance of the myocardium.

Riboxin is used for the treatment of ischemic heart disease, myocardial infarction, myocardial dystrophy, rhythm disturbances associated with the use of cardiac glycosides. It is also prescribed for liver diseases (hepatitis, cirrhosis) and for the treatment of urokoproporfirii. There is also evidence of the improvement of visual function in patients with glaucoma under the influence of Riboxin (open-angle form with intraocular pressure normalized under the influence of hypotensive therapy). The effect appears to be associated with the antihypoxic effect of the drug.

Ribboxin is taken orally before meals at a daily dose of 0.6 to 2, 4 g. In the first days, 0.6 to 0.8 g per day is taken (0.2 g 3 to 4 times a day), with good tolerability. increase the dose within 2 - 3 days from 1, 2 g per day (0.4 g 3 times) to 2, 4 g per day.

The course of treatment lasts from 4 weeks to 1, 5 - 3 months. With uracoproporphyria, riboxin is taken in a daily dose of 0.8 g (0.2 g each, 4 times) daily for 1,3 months.

Riboxin is also administered intravenously. Enter slowly in a stream or drip (40 - 60 drops per minute). Begin treatment with the introduction of 200 mg (10 ml of 2% solution) 1 time per day, then, with good tolerance, increase the dose to 400 mg (20 ml of 2% solution) 1 - 2 times a day. Duration of treatment is 10 - 15 days.

In acute disorders of the rhythm of the heart and conductivity, jet injection of the drug is possible in a single dose of 200-400 mg (10-20 ml of a 2% solution).

For drip, dilute the solution of riboxin in an isotonic solution of sodium chloride or 5% glucose solution to 250 ml.

The drug is usually well tolerated; in some cases, itching, skin flushing are possible; in these cases, the drug is canceled. In rare cases, there is an increase in the concentration of uric acid in the blood. With prolonged use in large doses, gout may worsen.

Method of production: tablets, coated (yellow), 0.2 g (Tabulettae Riboxini 0.2 obductae) in a package of 50 pieces; 2% solution in 10 ml ampoules.

Storage: List B. Tablets and ampoules at room temperature in a dark place.