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Description of the medicine: Riboxin (Riboxinum)

Riboxinum (Riboxinum). 9-b -D-Ribofuranosylhypoxanthine, or hypoxanthine riboside.

Synonyms: Inosie-F, Inosin, Atorel, Inosie-F, Inosin, Inosiron-E, Inotin, Irpelen, Oxiamin, Ribonosine, Teberin, Trophicardyl, etc.

White or white with a slight yellowish tinge, crystalline powder, bitter taste, odorless. Slowly and hardly soluble in water, very slightly soluble in alcohol.

Riboxin is a derivative (nucleoside) of purine. It can be considered as a precursor to ATP. There is evidence of the drug’s ability to increase the activity of a number of enzymes in the Krebs cycle, stimulate nucleotide synthesis, have a positive effect on metabolic processes in the myocardium and improve coronary circulation. By type of action, it refers to anabolic substances. Being a nucleoside, inosine can penetrate into cells and increase the energy balance of the myocardium.

Riboxin is used for the complex treatment of coronary heart disease, myocardial infarction, myocardial dystrophy, rhythm disturbances associated with the use of cardiac glycosides. It is also prescribed for liver diseases (hepatitis, cirrhosis) and for the treatment of urocoproporphyria. There is also evidence of an improvement in visual function under the influence of riboxin in patients with glaucoma (an open-angle form with intraocular pressure normalized under the influence of antihypertensive therapy). The effect is apparently associated with the antihypoxic effect of the drug.

Take riboxin orally before meals in a daily dose of 0.6 to 2, 4 g. In the early days, take 0.6 - 0.8 g per day (0.2 g 3-4 times a day), with good tolerance increase the dose over 2 to 3 days from 1, 2 g per day (0.4 g 3 times) to 2, 4 g per day.

The course of treatment lasts from 4 weeks to 1, 5 - 3 months. With urakoproporphyria, riboxin is taken in a daily dose of 0.8 g (0.2 g 4 times) daily for 1 to 3 months.

Riboxin is also used intravenously. Enter slowly jet or drip (40 - 60 drops per minute). Treatment begins with the introduction of 200 mg (10 ml of a 2% solution) once a day, then, with good tolerance, increase the dose to 400 mg (20 ml of a 2% solution) 1 to 2 times a day. The duration of treatment is 10 to 15 days.

In acute cardiac arrhythmias and conduction disorders, a single injection of the drug in a single dose of 200 to 400 mg (10 to 20 ml of a 2% solution) is possible.

For dropwise administration, a solution of riboxin in isotonic sodium chloride solution or 5% glucose solution is diluted to 250 ml.

The drug is usually well tolerated; in some cases, itching, flushing of the skin; in these cases, the drug is canceled. In rare cases, there is an increase in the concentration of uric acid in the blood. With prolonged use in large doses, aggravation of gout is possible.

Method of release: coated tablets (yellow), 0.2 g each (Tabulettae Riboxini 0.2 product) in a package of 50 pieces; 2% solution in ampoules of 10 ml.

Storage: List B. Tablets and ampoules at room temperature in a dark place.