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Description medications: Dalargin (Dalarginum)

DALARGIN (Dalarginum). Tyrosyl-2-alanyl-glycyl-phenylalanyl-leucyl-arginine.

The peptide compound consisting of 6 amino acid residues (hexapeptide). Available in a diacetate (X = 2SNzSOON). White amorphous powder, easily soluble in water and alcohol.

Detection of endorphins and enkephalins (see. Analgesic), and determination of their chemical structure led to a wide deployment of work on the synthesis of analogues and derivatives thereof. It received a large number of new peptide compounds having different kinds of neurotrophic (analgesic, hypnotic, antidepressant, etc.) Activity and other pharmacological properties (see. Also Timogen). For several reasons (lack stability;. Ineffective when administered orally and others) to the last time in the medical practice as drugs included small amounts of such compounds.

One of the compounds of this group, have found practical application, is the domestic product dalargin.

From the pharmacological properties dalargina most noteworthy of its antisecretory activity, the ability to accelerate the healing of gastric and duodenal ulcers, as well as hypotensive effects.

It is recommended for use as a therapeutic agent in acute gastric ulcer and duodenal ulcer. For this purpose, dalargin administered intravenously or intramuscularly. A single dose of 0.001 g (1 mg). Administered intramuscularly in 1 mL and intravenously - 5 - 10 ml of isotonic sodium chloride solution. Intramuscular injections were 2 times and 1 time intravenous daily. If necessary, a single dose of 0.002 g (2 mg) daily (i.m.) - up to 5 mg. The course of treatment lasts 3 - 4 weeks. The total dose per course of treatment is 30 - 50 mg.

For injection using dalargin lyophilized (Dalarginum lyophilisatum 0,001 Pro injectionibus), produced in the form of powder or porous mass in vials of 0,001 grams (1 mg).

Injectable solutions prepared immediately before use.

In severe pain symptoms may co-administration of antacids.

There are indications dalargina effectiveness in the treatment of obliterating diseases of the lower extremities.

There was also a positive impact dalargina (slow intravenous administration of 1 mg per 10 ml of isotonic sodium chloride solution) in the mental functions of patients with alcoholism.

Injections dalargina generally well tolerated; possible decrease in blood pressure.

The drug should not be used during pregnancy and hypotension.

Product: dried powder or porous mass in vials of 0,001 grams (1 mg) in packs of 5 ampoules.

Storage: List B. In the dark place at a temperature no higher than + 20 'C.