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Description of the medicine: Maprotiline (Maprotiline)

MAPROTILIN (Maprotiline) *. (3-Methylaminopropyl) dibenzo [b, e] -bicyclo [2, 2, 2] -octadiene.

Synonyms: Ludomil, Ladiomil, Ludiomil, Ludionil.

Maprotiline is a compound of a four-ring structure, close, however, in structure, especially along the side chain, to tricyclic antidepressants. On pharmacological properties, too, is close to the antidepressants of this group: it weakens the depressant effects of reserpine, enhances the action of phenamine. It is an inhibitor of monoamines reuptake, but differs in that relatively strongly inhibits the re-uptake of presynaptic nerve endings of norepinephrine. It enhances the pressor action of norepinephrine and epinephrine, has moderate cholinolytic activity. MAO does not induce inhibition.

Maprotiline has an antidepressant effect, accompanied by an anxiolytic and mild sedative effect.

Applied in various forms of depression, including reactive, neurotic, cyclothymic, involutional, etc., accompanied by fear, irritability.

Assign inside, starting with a dose of 50 mg 3 times a day; Then the dose is gradually increased, if necessary up to 300 mg per day. Elderly people are prescribed 10 mg 3 times a day, and if necessary, increase the dose to 25-50 mg 3 times a day. Ambulatory patients are prescribed 10 to 25 mg 3 times a day. In severe cases, maprotiline is sometimes injected into a vein at doses of 25 to 50 mg to 150 mg per day.

Possible side effects - dry mouth, constipation, urinary retention; Disorders of accommodation are less pronounced than with the use of amitriptyline and imipramine. Sometimes there is tachycardia and fluctuations in blood pressure. Allergic reactions may develop.

The drug is contraindicated in severe liver and kidney disease, with glaucoma, adenoma of the prostate.

Forms of release: dragees on 10; 25 and 50 mg; 1, 25% solution in ampoules of 2 ml (25 mg).