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Description of the medicine: Maprotiline (Maprotiline)

MACROTILINE (Maprotiline) *. (3-Methylaminopropyl) dibenzo [b, e] bicyclo - [2, 2, 2] octadiene.

Synonyms: Lyudiomil, Ladiomil, Ludiomil, Ludionil.

Maprotiline is a compound of a four-cyclic structure, close, however, in structure, especially along the side chain, to tricyclic antidepressants. By pharmacological properties, it is also close to the antidepressants of this group: it weakens the depressing effects of reserpine, enhances the action of phenamine. It is an inhibitor of reuptake of monoamines, but differs in that it inhibits the reuptake of presynaptic nerve endings of norepinephrine relatively strongly. It enhances the pressor effect of norepinephrine and adrenaline, has moderate cholinolytic activity. MAO does not cause inhibition.

Maprotiline has an antidepressant effect, accompanied by anxiolytic and moderate sedative effect.

It is used for various forms of depression, including reactive, neurotic, cyclothymic, involutional, etc., accompanied by fear, irritability.

Assign inside, starting with a dose of 50 mg 3 times a day; then the dose is gradually increased - if necessary up to 300 mg per day. Elderly people are prescribed 10 mg 3 times a day, and if necessary, increase the dose to 25 - 50 mg 3 times a day. Outpatients are prescribed 10 to 25 mg 3 times a day. In severe cases, maprotiline is sometimes injected into a vein in doses from 25-50 mg to 150 mg per day.

Possible side effects are dry mouth, constipation, urinary retention; disturbances of accommodation are less pronounced than with amitriptyline and imipramine. Tachycardia and fluctuations in blood pressure are sometimes observed. Allergic reactions may develop.

The drug is contraindicated in severe diseases of the liver and kidneys, with glaucoma, prostate adenoma.

Forms of release: 10 dragees; 25 and 50 mg; 1, 25% solution in ampoules of 2 ml (25 mg).