Medication Description: Maprotiline (Maprotiline)
MAPROTILIN (Maprotiline) *. (3-Methylaminopropyl) dibenzo- [b, e] -bicyclo- [2, 2, 2] octadiene.
Synonyms: Lyudiomil, Ladiomil, Ludiomil, Ludionil.
Maprotiline is a compound of a four-cyclic structure, however, its structure is close, especially along the side chain, to tricyclic antidepressants. In terms of pharmacological properties, it is also close to the antidepressants of this group: it weakens the depriving effects of reserpine, enhances the action of phenamine. It is an inhibitor of monoamine reuptake, but differs in that it relatively strongly inhibits the reuptake of presynaptic nerve endings of norepinephrine. It enhances the pressor action of norepinephrine and adrenaline, has a moderate anticholinergic activity. Inhibition of MAO does not cause.
Maprotiline has an antidepressant effect, accompanied by anxiolytic and moderate sedative effect.
Applied with various forms of depression, including reactive, neurotic, cyclothymic, involutional, etc., accompanied by fear, irritability.
Assign inside, starting with a dose of 50 mg 3 times a day; then gradually increase the dose - if necessary, up to 300 mg per day. Elderly persons are prescribed 10 mg 3 times a day, and if necessary, increase the dose to 25-50 mg 3 times a day. Outpatients prescribed 10-25 mg 3 times a day. In severe cases, maprotiline is sometimes injected into a vein in doses from 25–50 mg to 150 mg per day.
Possible side effects - dry mouth, constipation, urinary retention; accommodation disturbances are less pronounced than with amitriptyline and imipramine. Sometimes there is tachycardia and fluctuations in blood pressure. Allergic reactions may develop.
The drug is contraindicated in severe liver and kidney diseases, glaucoma, prostate adenoma.
Forms of release: a dragee on 10; 25 and 50 mg; 1, 25% solution in ampoules of 2 ml (25 mg).