Description of the medicine: Ceruloplasmin (Ceruloplasminum)

CERULOPLASMIN (Ceruloplasminum).

The glycoprotein of the α-globulin fraction of human serum.

It is available for medical use in the form of a lyophilized amorphous powder or a porous mass of blue (Blue color is due to the content of copper ions in the glycoprotein.) It is soluble in water, forms a weakly-salting solution of blue color. Hygroscopic.

Ceruloplasmin is a protein in the blood plasma that performs a number of important biological functions in the body; Increases the stability of cell membranes, participates in immunological reactions, ion exchange, has an antioxidant effect, inhibits lipid peroxidation, stimulates hemopoiesis. The content of ceruloplasmin in serum is significantly reduced in hepatocerebral degeneration (Wilson-Konovalov's disease), which is an important diagnostic index.

As a medicine used to stimulate hemopoiesis, reduce intoxication and immunological correction in the complex therapy of cancer patients; In the period of preoperative preparation in weakened patients with anemia, exhaustion, intoxication; In the early postoperative period in case of massive blood loss during surgery; With purulent-septic complications in early postoperatively chemotherapy of oncological patients, including in patients with hemoblastosis with mild intoxication.

Ceruloplasmin is also used in the complex therapy of patients with acute and chronic osteomyelitis.

Enter intravenously (30 drops per minute). The contents of 1 vial or ampoule are dissolved in 200 ml of 5% glucose solution or isotonic sodium chloride solution.

Oncological patients in the period of preoperative preparation, ceruloplasmin administered at a dose of 1, 5 - 2, 0 mg / kg; Course of treatment 7 - 10 infusions (every day or every other day, depending on the patient's condition).

In the postoperative period, a single dose is determined by the amount of blood loss and is from 1.5 mg / kg (with a small loss of blood) to 6 mg / kg (with large blood loss); The course of treatment consists of daily (1 time per day) infusions for 7 to 10 days.

When chemoradiotherapy, a single dose of 4 - 6 mg / kg, the course of treatment consists of 10 - 14 injections (3 injections per week). For patients with hemoblastoses, a single dose is 1, 5 - 3, 0 mg / kg, a course of treatment 7 - 10 injections, prescribed daily 1 time per day.

In acute osteomyelitis, the single dose is 2.5 mg / kg, the course of treatment consists of 5 injections, administered daily or every other day. In chronic osteomyelitis, ceruloplasmin is administered at 5 mg / kg 2 to 3 times at intervals of 1 to 2 days and then 3 to 7 injections are administered at 2.5 mg / kg every other day.

At the beginning of treatment with ceruloplasmin, there may be a sensation of blood rush to the face, nausea, chills, a brief increase in body temperature; Skin rashes (hives). In these cases, reduce the dose, reduce the rate of administration, or abolish the drug.