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Description of the medicine: Sydnophen (Sydnophenum)

Sydnophen (Sydnophenum). 3- (b - Phenylisopropyl) -sidononymine hydrochloride.

Fine crystalline powder, odorless, bitter taste, white or white with a slight yellowish tint. Easily soluble in water, soluble in alcohol.

Synonym: Feprosidnine hydrochloride.

Sidnofen belongs to the group of phenylalkyl sidnoniminov and is close in structure to sydnocarb (see).

Like sydnocarb, sydnofen has a stimulating effect on the central nervous system, however, it is inferior in this to sydnocarb and at the same time has a pronounced antidepressant activity, which makes it a very valuable drug for the treatment of asthenodepressive conditions.

The antidepressant effect of sydnophene can be explained by its ability to have a reversible inhibitory effect on MAO activity. It reduces the depriminating effects of reserpine, enhances the action of adrenaline and norepinephrine, and causes a moderate increase in blood pressure. It has anticholinergic activity,

It is used for asthenic conditions of various origins, for adynamia, lethargy, depression, apathy due to neurosis, after previous neuroinfections and for diseases of the endocrine glands (hypothyroidism, addisonism, etc.), for narcolepsy, pathological fatigue, as well as for simple depression, depression with inhibition in the framework of cyclothymia and with other indications for the use of stimulating and "light" antidepressant drugs,

Assign inside before meals, starting with 0.005 g (5 mg) 1 - 2 times a day; if necessary, increase the dose by adding 5 mg per day every 2 to 3 days to 0.02 to 0.03 g per day. Upon reaching the therapeutic effect, the dose is gradually reduced. The maintenance dose (if long-term treatment is necessary) is usually 0.005 g per day.

In severe asthenic conditions, the dose of Sindnophen can be gradually increased to 0.06 - 0.08 g (in a hospital setting).

Take Sydnofen in the morning.

When using the drug, an increase in blood pressure, headache, dry mouth, pain in the heart, and rarely allergic itching are possible. In these cases, it is necessary to reduce the dose or take a break in taking the drug.

In rare cases, a "paradoxical" reaction may occur - a sedative effect.

Sidnofen is contraindicated in patients with anxiety-depressive states (increased anxiety, exacerbation of hallucinatory-delusional syndrome are possible). Sydnophen should not be used simultaneously with antidepressants, MAO inhibitors and tricyclic antidepressants. Between the use of Sydnophene and antidepressants of these groups, as well as between antidepressants and Sydnophene, a break of at least a week should be observed.

Release form: tablets on 0,005 g (5 mg).

Storage: List A. In the dark place.