Description of drug: Sydnophenum (Sydnophenum)

Sydnophenum. 3- (b-Phenylisopropyl) -sodnonimine hydrochloride.

White or white with a weak yellowish hue, fine crystalline powder, odorless, bitter taste. Easily soluble in water, soluble in alcohol.

Synonym: Feprosidnine hydrochloride.

Sidnofen belongs to the group of phenylalkylsidnonimines and is close in structure to the sidnocarb (see).

Like sydnokarb, sydnofen has a stimulating effect on the central nervous system, but it is inferior in this sydnokarbu and at the same time has a pronounced antidepressant activity, which makes it a very valuable drug for the treatment of asthenodepressive states.

The antidepressant effect of sydnofen can be explained by its ability to exert a reversible inhibitory effect on the activity of MAO. It reduces the depressant effects of reserpine, increases the effect of epinephrine and norepinephrine, causes a moderate increase in blood pressure. Has anticholinergic activity,

Applied with asthenic conditions of various origins, with adynamia, lethargy, depression, apathy in connection with neuroses, after the transferred neuroinfections and with endocrine gland diseases (hypothyroidism, addisonism, etc.), with narcolepsy, pathological fatigue, as well as with simple depressions, depressions With retardation within the framework of cyclothymia and with other indications for the use of stimulant and <lung> antidepressant drugs,

Assign inside before meals, starting with 0.005 g (5 mg) 1 - 2 times a day; If necessary, increase the dose, adding 5 mg per day every 2 to 3 days, to 0.02 to 0.03 g per day. When the therapeutic effect is achieved, the dose is gradually reduced. The maintenance dose (if prolonged treatment is necessary) is usually 0.005 g per day.

In severe asthenic conditions, the dose of sindnofen can be gradually increased to 0.06-0.08 g (in hospital settings).

Take sydnophen in the morning.

With the use of the drug may increase blood pressure, headache, dry mouth, pain in the heart, rarely allergic itching. In these cases, you need to reduce the dose or take a break in taking the drug.

In rare cases, a "paradoxical" reaction, a sedative effect, can be observed.

Sydnofen is contraindicated in patients with anxiety-depressive conditions (there may be an increase in anxiety, exacerbation of hallucinatory-delusional syndrome). Do not use sydnofen simultaneously with antidepressants MAO inhibitors and tricyclic antidepressants. Between the use of sydnofen and antidepressants of these groups, as well as between antidepressants and sydnofen, a break of at least a week should be observed.

Form release: tablets to 0,005 grams (5 mg).

Storage: List A. In the dark place.