Medication Description: Lactulose (Lactulosum)
Lactulose refers to a synthetic disaccharide. Oral administration is not absorbed in the gastrointestinal tract. Once in the intestine, it stimulates peristalsis and eliminates constipation.
In addition, splitting in the colon, releases hydrogen ions, binds free ammonia, increases the diffusion of ammonia from the blood into the intestine and promotes the release of ammonia from the body.
Lactulose is used in a mixture with galactose and lactose as a syrup for chronic constipation, as well as for hepatic encephalopathy (hepatic coma and precomatosis), in patients with chronic liver diseases.
As a laxative, adults are usually prescribed 1 to 3 tablespoons of syrup a day for 3 days. Then use maintenance doses of 2 to 5 teaspoons per day. Children should be prescribed 1 to 3 teaspoons per day.
For liver diseases, adults take 2 to 3 tablespoons 3 times a day.
When using the drug may nausea, flatulence, diarrhea. In these cases, reduce the dose.
The drug is contraindicated in diabetes mellitus.
Product form: 500 ml bottles containing 100 g of 67 g of lactulose, about 11 g of galactose and 6 g of lactose, in the form of a syrup called Portalak (Portalak) *.
A similar drug, marketed under the name "Normase" (Normase, Italy), is recommended to be prescribed to adults with 7 ml constipation in the morning and evening before meals; with liver diseases - from 15 to 45 ml (1 - 3 tablespoons) 3 times a day. Children appoint 0.5 - 1, 0 ml per 1 kg of body weight (in the morning).