Description of the medicine: Sodium thiosulfate (Natrii thiosulfas)
SODIUM THIOSULPHATE (Natrii thiosulfas) (See also Magnesium sulfate).
Synonyms: Sodium hyposulfite, Natrium hyposulfurosum, Natrium thiosulfuricum.
Colorless, transparent, odorless crystals, bitter tasting. It is very soluble in water (1: 1), practically insoluble in alcohol. At a temperature of about + 50 ° C it melts in crystallization water.
An aqueous solution (30%, pH 7, 8 - 8, 4) is sterilized at a temperature of + 100 ° C for 30 minutes (20 g of sodium bicarbonate is added per 1 liter of solution).
Sodium thiosulfate has anti-toxic, anti-inflammatory and desensitizing effects.
As an anti-toxic agent, it is used for poisoning with arsenic, mercury, and lead compounds (non-toxic sulfites are formed), hydrocyanic acid and its salts (less toxic rhodanic compounds are formed), iodine and bromine salts.
5 to 10 ml of a 30% solution is administered intravenously, and 50 ml of a 30% solution for cyanide damage. Inside appoint 2-3 g to receive in the form of a 10% solution in water or in an isotonic solution of sodium chloride.
It is also prescribed intravenously and orally for allergic diseases, arthritis, neuralgia.
It is used externally for the treatment of patients with scabies (see also Benzyl benzoate) according to the Demjanovich method, based on the ability of sodium thiosulfate to decompose in an acidic environment, releasing sulfur and sulfur dioxide, which have an antiparasitic effect. A 60% sodium thiosulfate solution is rubbed into the skin (2 to 3 minutes in succession in the left and right upper limbs, trunk, left and right lower limbs, for a total of 10-15 minutes). After rubbing, take a break for several minutes until the skin dries and crystals appear on it. Then, a second rubbing cycle is performed in the same sequence. After the skin has dried, rub a 6% solution of hydrochloric acid, pouring it into the palm of your hand, in the same order 3-4 times for 10 15 minutes with interruptions until the solution dries on the skin after each rubbing. Washing is allowed after 3 days.
Method of release: powder; 30% solution in ampoules of 5; 10 and 50 ml.
Rp: Natrii thiosulfatis 10.0
Aq. destill. 100 ml
M.DS Inside, 1 to 2 tablespoons in 5 to 10 minutes
Rp .: Sol. Natrii thiosulfatis 30% 5 ml
DtdN 6 in ampull.
S. 5 ml per vein.