Medication Description: Tetacin Calcium (Tetacinum-calcium)
Calcium disodium salt of ethylenediaminetetraacetic acid.
Synonyms: Сalcium disodium, Chelaton, Edatacal, Edathamil calcium disodium, EDTA, Mosatil, Natrii calcii edetas, Sodium calcium edetate, Tetraceminum, Versenate calcium disodium, etc.
Available in the form of a 10% solution for injection (Solutio Tetacini-calcii 10% pro injectionibus). Colorless clear liquid; pH 5, 0 - 7, 0.
Tetanine-calcium (CaNa 2 EDTA) refers to complexing compounds. This is a cyclic complex compound, where calcium can be replaced by metal ions with the formation of low-toxic water-soluble compounds that are rapidly eliminated from the body. Calcium is capable of being replaced only by ions of those metals that are more stable than himself; Lead, thorium, and others are among them. With barium, strontium, and other ions, whose stability constant is lower than that of calcium, thetacin-calcium does not react.
Used in acute and chronic poisoning with heavy and rare-earth elements and their compounds (lead, cadmium, cobalt, mercury, uranium, yttrium, cerium, etc.).
Assign inside and intravenously.
Intravenously administered by the drip method in an isotonic solution of sodium chloride or in 5% glucose solution. Single dose of 2 g (20 ml of 10% solution), daily 4 g. With the introduction of 2 times a day, the interval between injections should be at least 3 hours. Enter daily for 3 to 4 days, followed by an interval of 3 to 4 days. The course of treatment is 1 month.
For oral administration (for chronic intoxication with lead and other heavy metals) tablets containing 0.5 g of thetacalcine can be used. Assign per day to 2 g of the drug (0.5 g 4 times or 0.25 g 8 times), regardless of the meal. Take the drug after 1 or 2 days (3 4 times a week), the course of treatment lasts 20 to 30 days; a total of 20 g or more are accepted for the course (but not more than 30 g). Compared with intravenous administration, treatment with pills gives a slower therapeutic effect (elimination of lead colic occurs on the 7th-10th day of treatment).
If, after the course of treatment, contact with lead continues and symptoms of intoxication reappear, then thetacin-calcium tablets may be repeated, but not earlier than after 1 year.
Thetacin-calcium is contraindicated in nephritis, nephrosis, liver diseases with a violation of its function. There are indications that the use of large quantities of the drug (50 - 60 g) can cause disturbances in the activity of the gastrointestinal tract and kidneys (toxic nephrosis). During treatment, blood levels of hemoglobin, iron, and vitamin B 12 may decrease.
In case of acute food poisoning with metals, administration of the drug is allowed only after thorough cleaning of the gastrointestinal tract (gastric lavage, siphon enemas). It should be borne in mind that the complexes with metals formed upon the introduction of thetacin-calcium are easily soluble and can be absorbed from the gastrointestinal tract, enhancing the effects of intoxication.
In the course of treatment, it is recommended to prescribe iron orally and vitamin B 12 (5-6 injections of 100 µg every other day).