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Description medications: Tetatsin calcium (Tetacinum-calcium)

TETATSIN calcium (Tetacinum-calcium).

Calcium disodium edetate.

Synonyms: Salcium disodium, Chelaton, Edatacal, Edathamil calcium disodium, EDTA, Mosatil, Natrii calcii edetas, Sodium calcium edetate, Tetraceminum, Versenate calcium disodium and others.

Available in a 10% solution for injections (Solutio Tetacini-salcii 10% pro injectionibus). Colorless transparent liquid; pH 5, 0 - 7 0.

Tetanin calcium (EDTA SaNa 2) relates to complexing compounds. This complex cyclic compound wherein calcium is able to be replaced with metal ions to form a low-toxic water-soluble compounds, quickly withdrawn from the body. Calcium is able to be replaced with only ions of those metals which are more stable than he himself; these include lead, thorium, and others. Since ions of barium, strontium, et al., the stability constant which is less than that of calcium, calcium tetatsin does not come into engagement.

Applied with acute and chronic poisoning and heavy rare earth elements and their compounds (lead, cadmium, cobalt, mercury, uranium, yttrium, cerium and others.).

Assign inside and intravenously.

Administered by intravenous drip in an isotonic sodium chloride solution or 5% glucose solution. A single dose of 2 g (20 ml of a 10% solution), 4 g daily When administered 2 times a day interval between injections must not be less than 3 hours is administered daily for 3 -. 4 days followed by a break 3 - 4 days. The course of treatment 1 month.

For oral administration (at chronic intoxication with lead and other heavy metals) may be used tablets, containing 0.5 g tetatsinkaltsiya. Assign day 2 g of product (0,5 g, 4 times or 8 times, 0.25 g), regardless of the meal. Take medication after 1 or 2 days (3 to 4 times a week), the course of treatment lasts 20 - 30 days; take 20 grams or more (but not more than 30 g), only the course. Compared with intravenous administration, tablets treatment gives the slower therapeutic effect (elimination of lead colic occurs at 7 - 10 day treatment).

If, after the course of treatment is continued contact with lead and symptoms of intoxication reappear, it is possible to repeat the course of treatment tablets tetatsin calcium, but not earlier than 1 year.

Tetatsin calcium is contraindicated in nephritis, nephrosis, liver diseases in violation of its functions. There are indications that the application of large amounts of the drug (50 - 60 g) may induce disturbances in the gastrointestinal tract and kidney (toxic nephrosis). During treatment, may decrease blood levels of hemoglobin, iron and vitamin B12.

In acute food poisoning metals administration of the drug is allowed only after a thorough cleaning of the gastrointestinal tract (gastric lavage, enema siphon.). Note that when administered tetatsin generated calcium metal complexes are soluble and can easily be absorbed from the gastrointestinal tract, increasing toxicity phenomena.

In the course of treatment is recommended to prescribe iron supplements inside and vitamin B 12 (5 - 6 injections of 100 mg every other day).