Medication Description: Pentacin (Pentacinum)
Calcium-trisodium salt of diethylene-triaminopentacetic acid.
Synonyms: Calcii trinatrii pentetas, Calcium trisodium pentetate, Penthamil.
White crystalline powder. Easily soluble in water, practically insoluble in alcohol. Aqueous solutions (pH 5% solution 5, 5-6, 8) are sterilized at a temperature of + 100 ° C for 30 minutes.
Refers to complexing compounds.
Used in acute and chronic poisoning with plutonium, radioactive yttrium, cesium, zinc, lead and a mixture of fission products of uranium, as well as to identify the carriage of these radioisotopes. It has no significant effect on the elimination of uranium, polonium, radium and radioactive strontium and lead.
The drug does not affect the content of blood calcium and potassium.
Apply intravenously in the form of a 5% aqueous solution.
A single dose of 0.25 g of the drug (5 ml of 5% solution). In acute cases, a single dose can be increased to 1, 5 g (30 ml of 5% solution). Injected slowly, observing the state of the cardiovascular system. Injections produce in 1 to 2 days; for a course of 10 - 20 injections.
With prolonged use of pentacin, its effectiveness with respect to the removal of radioactive isotopes decreases; after cessation of drug administration, the effectiveness is gradually restored. In this regard, the treatment is carried out in separate courses with breaks between 3 and 4 months.
When exacerbation of the phenomena of lead intoxication (lead colic) is administered intravenously, 1 - 2 g (20 - 40 ml of 5% solution).
To identify the carrier of radioactive isotopes and lead, pentacin is prescribed 3 days in a row at therapeutic doses and the content of isotopes and lead in the urine is examined. Preliminary for 3 days conduct a control (background) study.
When using pentacin in some cases, dizziness, headaches, pain in the limbs and in the chest area are possible. These phenomena usually go away on their own. In case of nausea and vomiting, reduce the dose or stop using the drug. When signs of impaired coronary blood circulation, the drug is canceled.
When treating with pentacine, a general urine analysis should be carried out at least once a week and determination of radioactive isotopes should be determined with urine. In order to avoid kidney damage and electrolyte imbalance, it is necessary to observe the intervals between the courses of injection of the drug.
Pentacin is contraindicated in febrile conditions, lesions of the renal parenchyma, hypertension with impaired renal function, as well as in patients with vasospasm of the heart.
Product form: 5% solution in 5 ml ampoules in a package of 10 ampoules.
Storage: in a cool, dark place.