Description of the medicine: Pentacin (Pentacinum)
Calcium trisodium salt of diethylene triaminopentaacetic acid.
Synonyms: Calcii trinatrii pentetas, Calcium trisodium pentetate, Penthamil.
White crystalline powder. Easily soluble in water, practically insoluble in alcohol. Aqueous solutions (pH of a 5% solution of 5, 5-6, 8) are sterilized at a temperature of + 100 ° C for 30 minutes.
Refers to complexing compounds.
It is used for acute and chronic poisoning with plutonium, radioactive yttrium, cesium, zinc, lead and a mixture of uranium fission products, as well as for detecting the carriage of these radioisotopes. It does not significantly affect the excretion of uranium, polonium, radium, and radioactive strontium and lead.
The drug does not affect the blood levels of calcium and potassium.
It is administered intravenously in the form of a 5% aqueous solution.
A single dose is 0.25 g of the drug (5 ml of a 5% solution). In acute cases, a single dose can be increased to 1.5 g (30 ml of a 5% solution). Enter intravenously slowly, observing the state of the cardiovascular system. Injections are performed after 1 to 2 days; on a course of 10 to 20 injections.
With prolonged use of pentacin, its effectiveness with respect to the removal of radioactive isotopes decreases; after discontinuation of the drug, effectiveness is gradually restored. In this regard, the treatment is carried out in separate courses with breaks between them 3 to 4 months.
With an exacerbation of the phenomena of lead intoxication (lead colic), 1 to 2 g (20 to 40 ml of a 5% solution) is administered intravenously.
To identify carriers of radioactive isotopes and lead, pentacin is prescribed for 3 consecutive days in therapeutic doses and the content of isotopes and lead in the urine is examined. A control (background) study is carried out preliminary within 3 days.
When using pentacin in some cases, dizziness, headaches, pains in the limbs and in the chest area are possible. These phenomena usually pass independently. In case of nausea and vomiting, reduce the dose or stop using the drug. With signs of a violation of coronary circulation, the drug is canceled.
During treatment with pentacin, a general urinalysis should be performed at least 1 time per week and the excretion of radioactive isotopes with urine should be determined. In order to avoid damage to the kidneys and electrolyte imbalance, it is necessary to observe breaks between courses of injection of the drug.
Pentacin is contraindicated in cases of fever, damage to the renal parenchyma, hypertension with impaired renal function, as well as in patients with spasms of heart vessels.
Release form: 5% solution in ampoules of 5 ml in a package of 10 ampoules.
Storage: in a cool, dark place.