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Description medications: deferoxamine (Deferoxaminum)

Deferoxamine (Deferoxaminum) *.

N- [5- {3 - [(5-aminopentyl) oksikarbamoil] propionamide} -pentyl] -3 - {[5- (Noksiatsetamido) pentyl] carbamoyl} -propiongidroksamovaya acid.

Available in the form of the methanesulfonate.

Synonyms: Desferal, Desferal, Deferoxaminum methansulfonat, Desferan, Desferex, Desferin, Desferrioxamin, DFOM.

The drug forms a complex compound with iron. When introduced into the body facilitates removal of iron from iron-containing proteins (ferritin and hemosiderin), but not from hemoglobin and iron-containing enzymes. It does not significantly affect the selection of metals and other trace elements.

Apply at the primary and secondary hemochromatosis, gemosideroze and in acute iron poisoning.

The average initial dose of 1 g per day (1 - 2 injections); a maintenance dose of 0.5 grams per day.

Enter usually intramuscularly. Apply 10% solution, to which the contents of one vial (0.5 g) was dissolved in 5 ml of sterile water for injection. Intravenous drip is administered only to a maximum of 15 mg / kg per hour; the maximum dose of 80 mg / kg.

In acute poisoning with iron administered oral and parenteral. To bind iron, yet the dose absorbed from the gastrointestinal tract are inside 5 - 10 grams of the drug, ie, the contents of 10 -.. 20 vials (dissolved in drinking water). To delete iron grown deep intramuscular injection of 1 - 2 g every 3 -. 1 h 12 In severe cases, administered a drip into a vein

In applying the drug may occur in some cases of urticaria and exanthema. Rapid intravenous injection may bring to the collapse. With long-term use of the drug is required before and during treatment to investigate the condition of the eye. (In animal experiments, long-term use of large doses observed clouding of the lens.)

Before and during treatment it is necessary to investigate the release of iron in the urine.

The drug is contraindicated in pregnancy.

Product: in ampoules containing 0.5 g (500 mg) of dry product.