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Description of the medicine: Beroxanum

BEROXANE (Beroxanum).

The preparation containing a mixture of two furokoumarins - xanthotoxin and bergapten, isolated from the fruits of the plant parsnip of sowing (Rastinaca sativa L.), family. Umbrella, celery - Umbelliferae or Ariaceae.

Chemically, the xanthate toxin is 8-methoxy-6, 7-furocoumarin or 8-methoxy-psoralen, and bergapten is 5-methoxy-6, 7-furocoumarin.

White with a yellowish tinge crystalline powder odorless. Virtually nerastvorim in water, little soluble in alcohol, easily - in chloroform.

Xanthotoxin is produced abroad under the names: Pouvalene, Ammoidin, Meladinine, Meloxine, Methoxsalen, Methoxypsoralen, Methoxysalen, Metoxin, Oxsoralen, Puvalen, Xanthioxin and others.

The use of Beroxane in medical practice is based on the property of various furocoumarins (xanthotoxin, etc.) to sensitize the skin to light and stimulate melanocyte formation of the endogenous skin pigment (tryptophan derivative) of melanin when irradiated with ultraviolet rays. This property is also possessed by other preparations containing furocoumarins. When used in conjunction with ultraviolet irradiation, these drugs can help restore skin pigmentation in vitiligo. When depigmentation of the skin (leukoderma), associated with the destruction of melanocytes, the effect is not observed. In some cases, furokumariny effective in nest (circular) alopecia.

A very effective method of treating a number of skin diseases: psoriasis, fungal mycosis, vitiligo, etc. - is photochemotherapy. In this method, photosensitizing preparations are combined with irradiation with long-wave ultraviolet rays (320-390 nm). Various furocoumarins (Beroxane, psoralen, etc.) are used as a photosensitizer, the most effective of them being 8-methoxypsoralen (8-MOS), i.e. xanthotoxin, produced abroad under the name "Puvalen" (Puvalen).

When applying the photochemotherapy method (PUVA-therapy), 8-MOP is administered inside only on the day of irradiation 2 hours prior to the session. The dose of the drug depends on the weight of the patient; From 2 to 4 tablets (15 mg each) with a body weight of 50 to 90 kg.

Beroxane (in connection with the content of only a part of xanthotoxin in it) is inferior to the effectiveness of 8-MOS in photochemotherapy by the method of long-wave UV rays.

There are data on the effectiveness of photochemotherapy with a combination of long-wave UV irradiation, with external application of furocoumarins; On the foci of lesions, solutions of 8-MOS, beroksina (0.5%) or psoralen (0.1%) are applied.

Beroxane is prescribed for vitiligo and alopecia areal inside as tablets and externally in the form of a solution for rubbing.

Inside appoint to 0.02 g (1 tablet) at the reception; Take in the morning from 1 to 4 times (depending on the individual sensitivity and season of the year) for 1 tablet for 4 - 3 - 2 and 1 h before irradiation. The course consists of 4 - 6 cycles with breaks between them 15 - 20 days. The total dose for the course of treatment is 250-300 tablets for adults. For children older than 5 years, the dose decreases by 1/3 - 1/2 depending on the age.