Medication Description: Ammifurin (Ammifurinum)
Contains a mixture of three furocoumarins: isopimpinellin, bergaptena (see) and xantotoxin (see) isolated from the seeds of the plant ammi large (Ami majus L.), herewith. umbrella (umbelliferae).
Light yellow or light yellow with a greenish tinge odorless crystalline powder. Practically insoluble in water, slightly soluble in alcohol, easily in chloroform.
Chemically close to beroxan. Bergapten is a part of both drugs, and isopimpinellin is 5, 8-dimethoxy-6, 7-furocoumarin, i.e. compared with bergapten and xanthotoxin, contains an additional group OCH3.
The effect of ammifurin, indications for use, possible complications and contraindications are the same as with the use of beroxan.
The drug is taken orally after a meal, drinking milk, at a dose of 0.8 mg / kg, but not more than 0.08 g per dose, once 2 hours before ultraviolet radiation. A 0.3% solution is applied externally to the lesions 1 hour before irradiation.
The course dose is 100 to 150 tablets (2 to 3 g) or 1 to 2 vials of a 0.3% solution (0.15 to 0.3 g). Repeated courses are carried out in 1 -1, 5 months.
Patients with limited lesions sometimes prescribed only externally (in combination with ultraviolet radiation).
There is a positive experience with the use of ammifurin by the method of PUVA-therapy.
Method of production: tablets of 0.02 g in a package of 100 pieces; 0.3% solution in orange glass bottles of 50 ml.
Storage: List B. In the dark, cool place.