Medication Description: Teturam (Teturamum)
Synonyms: Antabus, Abstinyl, Alcophobin, Antabus, Antaethan, Antaethyl, Anticol, Aversan, Contrapot, Crotenal, Disetil, Disulfiramum, Espenal, Exhorran, Hoca, Noxal, Refusal, Stopethyl, Tetradin, etc.
White with a faint yellowish-greenish white crystalline powder. It is difficult to dissolve in alcohol, practically insoluble in water, acids and alkalis.
It is taken orally for the treatment of chronic alcoholism, in cases where it is not possible to obtain a therapeutic effect by other methods of treatment (psychotherapy, vitamin therapy, taking apomorphine, etc.).
The action of the drug is based on its ability to specifically influence the exchange of alcohol in the body. Alcohol undergoes oxidative transformations, passing through the phase of acetaldehyde and acetic acid. With the participation of acetaldehyde oxidase, acetaldehyde is usually rapidly oxidized.
Teturam, blocking the enzymatic biotransformation of alcohol, leads to an increase in the concentration of acetaldehyde in the blood after taking alcohol.
According to modern data, teturam is converted in the body into N, N-diethyldithiocarbamic acid (DEDCK) and other metabolites that block metal ions and sulfhydryl groups of enzymes involved in the neutralization of alcohol. Accumulation of acetaldehyde after alcohol intake leads to severe changes in the body for the patient: reddening of the skin, sensation of heat in the face and upper body, chest tightness, difficulty breathing, noise in the head, palpitations, fear, sometimes chills, etc. Significantly lowers blood pressure.
When prescribing alcohol against the background of teturam action, they develop a negative conditioned reflex to the taste and smell of alcoholic beverages, and with prolonged treatment they achieve partial or complete intolerance to alcohol.
The use of teturam may be accompanied by severe side effects, therefore, it is resorted to as one of the last means.
Before treatment with teturam, the patient is subjected to a thorough medical examination. In the absence of contraindications, the patient is explained the meaning of therapy and is warned about the danger of taking alcohol during the treatment period.
Teturam treatment is carried out under medical supervision. Dose picked individually. Optimal doses (0.25 - 0.5 g / day), as a rule, are well tolerated and do not give complications even with prolonged use. Doses of teturam below 0.15 g / day are rapidly eliminated from the body and do not cause the desired effect — sensitization to alcohol.
Teturam treatment is usually carried out as follows. The first teturamalcic test is carried out 7 to 10 days after the start of treatment. After taking the morning 0.5 to 0.75 g of teturam, the patient takes 20 to 30 ml of an alcoholic beverage, usually 40% vodka. Repeated tests in stationary conditions are carried out in 1 - 2 days, on an outpatient basis - in 3 - 5 days. With a weak reaction, the dose of alcoholic drink is increased with the next sample by 10 - 20 ml. The maximum dose of vodka 100 - 120 ml.