Description of the medicine: Lithium oxybutyrate (Lithii oxybutyras)
LITHIUM OXIBUTIRATES (Lithii oxybutyras).
Lithium g - hydroxybutyrate.
Crystal powder, white or white with a barely noticeable creamy tint. Easily soluble in water, difficult in alcohol; pH of a 20% aqueous solution of 8, 5 - 9, 5.
The chemical structure is a lithium analogue of sodium oxybutyrate (see).
The therapeutic effect of the drug is mainly associated with the presence of lithium ion in its molecule, however, the drug also has elements of the activity characteristic of sodium oxybutyrate, it has a sedative effect. Compared to lithium carbonate, oxybutyrate is less toxic and more active. Lithium oxybutyrate can be administered intramuscularly.
Indications for use are basically the same as for lithium carbonate: hypomanic and manic states and the prevention of attacks of affective disorders. The drug is also used for psychopathy, neurosis, organic and other diseases with recurrent affective disorders.
Prescribe lithium oxybutyrate orally (after eating) or intramuscularly. A single dose - starting from 0.5 - 1 g, daily - up to 3 g (in 2 - 3 doses). With severe psychomotor agitation or patient refusal to take the drug inside it is administered intramuscularly.
When used as a preventive measure, they start with a dose of 0.5 g.
Lithium oxybutyrate is also prescribed as an antihypoxic agent. There is evidence of the antiarrhythmic effect of the drug, as well as the use of lithium carbonate for the correction of neutropenia in radiation treatment of patients with lymphogranulomatosis. The drug was found to cause a true increase in granulocyte production.
In all cases of lithium oxybutyrate use, all safety precautions must be observed and the contraindications provided for other lithium-containing preparations should be taken into account (see Lithium carbonate).
Method of release: tablets of 0.5 g; 20% solution in ampoules of 2 ml (0.4 g in ampoule).
Storage: List B. In a dry place.