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Medication Description: Bicillin-1 (Bicillinum-1)

BICYLLIN-1 (Bicillinum-1).

N, N-Dibenzylethylenediamine salt of benzylpenicillin.

Synonyms: Benzacillin, Benzatini, Benzethacil, Benzylpenicillin-Benzatine, Benzylpenicillinum, Diaminpenicillin, Dibencil, Duapen, Duropenin, Extencillin, Moldamin, Penadur, Tardocillin, etc.

White powder that forms a stable suspension when water is added. Practically insoluble in water, very little in alcohol.

Bicillin-1 is a drug of prolonged action. When administered intramuscularly in the form of a suspension, it is slowly absorbed and for a long time enters the blood.

Applied with infectious diseases caused by pathogens sensitive to penicillin (streptococci, pneumococci, staphylococci, etc.).

Especially shown is the use of bicillin-1, if necessary, to create a long-term therapeutic concentration of penicillin in the blood. It is also indicated for the prevention and treatment of rheumatism and the treatment of syphilis (see also Bicillin-5).

The drug is administered only intramuscularly. Intravenous and endolyumbalny is not allowed.

Suspension of bicillin-1 is prepared aseptically immediately before use: 2-3 ml of sterile water for injection or isotonic sodium chloride solution are introduced into a bicillin vial, the mixture is stirred until a uniform suspension is obtained, which is introduced deep into the upper outer quadrant of the buttock.

Adults are administered 300,000 or 600,000 IU once a week or 1,200,000 IU once every 2 weeks.

Children are administered at the rate of 5000 - 10 000 IU per 1 kg of body weight once a week or at the rate of 20 000 IU per 1 kg of weight 1 time in 2 weeks. More frequent injections are not allowed.

When treating rheumatism, the dose of bicillin-1 for adults can be increased to 2,400,000 U, 2 times a month. For the prevention of recurrence of rheumatism, they prescribe bicillin-1 (or bicillin-5) intramuscularly, 600 000 IU once a week for 6 weeks in combination with taking acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs.

For the treatment of syphilis, bitsillin-1 is used according to special instructions.

After injection of the drug (as well as other prolonged preparations of penicillin), pain at the injection site is possible.

Contraindications and precautions are the same as for benzylpenicillin sodium salt.

Product: in bottles of 300 000; 600,000; 1,200,000 and 2,400,000 units based on benzylpenicillin.

Storage: List B. In a dry cool place.