Description medications: carbenicillin disodium salt (Carbenicillinum-dinatricum)

Carbenicillin disodium salt (Carbenicillinum-dinatricum).

The disodium salt of 6- (a -karboksifenilatsetamido) -penitsillanovoy acid.

Synonyms: Anabactyl, Carbapen, Carbecillinum disodium, Carbecin, Carbipen, Fugacillin, Geopen, Gripenin, Microcillin, Piopen, Pyocianil, Pyocillin, Pyopan, Pyopen, Rexcilina and others.

Powder or porous mass of white or nearly white. Hygroscopic. Easily soluble in water, slowly - in alcohol.

The drug is a semisynthetic derivative of penicillin. It has a broad spectrum of antimicrobial activity against gram-positive and gram-negative microorganisms. In strains of staphylococci, penicillinase forming, the drug does not work.

Provided largely kidneys.

Assign of diseases caused by Gram-negative microorganisms sensitive to this antibiotic: urinary tract infections, septicemia, endocarditis, meningitis, osteomyelitis, peritonitis, purulent otitis media, wound infections, infected burns and OE use of the drug for infections caused by Gram-positive microorganisms, is inappropriate.

Enter intramuscularly or intravenously (bolus or infusion).

In severe infections (septicemia, meningitis, endocarditis, osteomyelitis, peritonitis) caused by Ps. aeruginosa, Rroteus vulgaris and other gram-negative organisms, it is necessary to maintain high concentrations in the blood of the drug, which is achieved by its intravenous administration.

Intramuscular administration of carbenicillin daily dose for adults is from 4 to 8 g, for children 50 - 100 mg / kg. The daily dose is divided into 4 - 6, individual doses. For intramuscular administration of 1 g of the drug dissolved in 2 ml of sterile water for injection.

For intravenous (bolus or infusion) administered at a speed of 50 100 droplets per minute, the daily dose of carbenicillin disodium salts for adults is 20 - 30 g, for children 250 -400 mg / kg. For intravenous use solution with a concentration not exceeding 1 g in 10 ml of 5% glucose solution or isotonic sodium chloride solution. The daily dose is divided into 6 individual doses.

Solutions of carbenicillin disodium salt prepared immediately before administration. The duration of treatment depends on the type and severity of the disease and is 10 - 14 days.

When using carbenicillin disodium salt of possible allergic reactions that require discontinuation of the drug and desensitizing therapy. Intramuscular injection can be painful and may develop phlebitis when administered into a vein. In patients with impaired renal function, high doses of the drug may lead to the development of hemorrhagic syndrome (due to blood clotting disorders). The drug enhances the action of oral anticoagulants.

Carbenicillin is contraindicated in case of hypersensitivity to other penicillins.

Product: in vials of 1 g per pack of 20 pieces.

Storage: List B. In the dark place at a temperature not higher than + 5 C.