Attention! Information is for reference only!
Before taking the course, consult a doctor!
WEB SITE ONLY DIRECTORY. NOT PHARMACY! We do not sell medicines! None!

Description of the medicine: Cephaloridine (Cefaloridinum)

Cefaloridinum *.

Semisynthetic antibiotic, obtained on the basis of 7-aminocephalosporanic acid (7-ACS).

Synonyms: Ceporin, Aliporina, Ampligran, Cefalisan, Cefalobiotic, Ceflorin, Cepaloridin, Cepalorin, Cephalomycine, Cephaloridine, Ceporan, Ceporin, Cinorin, Endosporol, Gencefal, Glaxoridin, Intrasporin, Keflodin, Keflordin, Latorex, Lauridin, Loridine, Prinderin, Sasperin, Sefacin, Sintoridyn, Total-minicina, and others.

White crystalline powder, readily soluble in water. Water solutions darken in the light.

The drug has an antibacterial effect on gram-positive and gram-negative coccal microorganisms (staphylococci, pneumococci, streptococci, gonococci, meningococci), anthrax rods. Operates on staphylococci, resistant to penicillins. Effective against spirochetes and leptospira. Does not affect the mycobacterium tuberculosis, rickettsia, viruses, protozoa.

Like penicillins, cephaloridine has a bactericidal effect.

The mechanism of action is associated with inhibition of the biosynthesis of the bacterial cell membrane.

When ingesting cephaloridine is poorly absorbed, therefore it is used parenterally. With intramuscular and intravenous administration, a therapeutic concentration in the blood and tissues is quickly achieved. In the cerebrospinal fluid penetrates slowly. It is allocated mainly by the kidneys in the unmodified form; If there is a violation of the excretory function of the kidneys, excretion from the body slows down.

Applied in acute and chronic infections of the respiratory system, urinary tract, genital organs, soft tissue infections, peritonitis, postoperative infection, sepsis, endocarditis, syphilis and other infections caused by microorganisms sensitive to the preparation. High efficacy of the drug in gonorrhea was noted.

Good results are noted when treating cephaloridine with antibiotic-resistant staphylococcal infections, including severe staphylococcal pneumonia, septicemia, septic endocarditis.

The drug can be used for allergies to penicillins.

Enter mainly intramuscularly. Intravenous (microfluid or drip) is administered in severe infections and the need to quickly create a high concentration of antibiotic in the blood. If necessary, you can also enter in the cavity (pleural, abdominal), endolumbular.

For infections of moderate severity caused by gram-positive bacteria, adults are administered at a rate of 20 to 30 mg / kg per day (in 2 to 3 doses).

For infections caused by gram-negative bacteria, adults and children are prescribed 40 to 60 mg / kg per day (2 to 3 doses), with very serious infections (endocarditis, sepsis) and chronic purulent bronchitis - 60-100 mg / kg per day (In 2 - 4 admission). Newborns are prescribed at a rate of 15 30 mg / kg per day (in 2 divided doses), older children 20-30 mg / kg.

The highest daily intake for adults is 6 g.

When empyema, the pleura is injected additionally into the pleural cavity for 0.25 g of the drug.

When meningitis is prescribed intramuscularly or intravenously - to children at 60 mg / kg per day, adults - 1 g, every 6 hours.