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Description of the medicine: Cephaloridin (Cefaloridinum)

CEPHALORIDIN (Cefaloridinum) *.

Semisynthetic antibiotic based on 7-aminocephalosporanic acid (7-ACC).

Synonyms: Zeporin, Aliporina, Ampligran, Cefalisan, Cefalobiotic, Ceflorin, Cepaloridin, Cepalorin, Cephalomycine, Cephaloridine, Ceporan, Ceporin, Cinorin, Endosporol, Lencefinorfinorfinorfinorfinorfinorfinorfinorfinorfinorfinorfinorfinorf Sefacin, Sintoridyn, Total-minicina, etc.

White crystalline powder, soluble in water. Aqueous solutions darken in the light.

The drug has an antibacterial effect on gram-positive and gram-negative coccal microorganisms (staphylococci, pneumococci, streptococci, gonococci, meningococci), anthrax bacilli. It acts on staphylococci resistant to penicillins. Effective against spirochetes and leptospira. Does not affect mycobacterium tuberculosis, rickettsia, viruses, protozoa.

Like penicillins, cephaloridin has a bactericidal effect.

The mechanism of action is associated with inhibition of the biosynthesis of the bacterial cell membrane.

When administered, cephaloridin is poorly absorbed, therefore, it is used parenterally. With intramuscular and intravenous administration, a therapeutic concentration in the blood and tissues is quickly achieved. It enters the cerebrospinal fluid slowly. It is allocated mainly by kidneys in unchanged form; in violation of the excretory function of the kidneys, excretion from the body slows down.

It is used for acute and chronic infections of the respiratory system, urinary tract, genital organs, soft tissue infections, peritonitis, postoperative infection, sepsis, endocarditis, syphilis and other infections caused by microorganisms sensitive to the drug. High efficacy of the drug in gonorrhea was noted.

Good results have been observed with cephaloridine treatment with antibiotic-resistant staphylococcal infections, including severe staphylococcal pneumonia, septicemia, and septic endocarditis.

The drug can be used for allergies to penicillins.

Introduced mainly intramuscularly. Intravenously (micro-jet or drip) is administered for severe infections and the need to quickly create a high concentration of antibiotic in the blood. If necessary, you can also enter the cavity (pleural, abdominal), endolumbar.

For moderate infections caused by gram-positive bacteria, adults are administered at a rate of 20-30 mg / kg per day (in 2 to 3 doses).

In infections caused by gram-negative bacteria, it is prescribed to adults and children 40-60 mg / kg per day (in 2 to 3 doses), in case of very severe infections (endocarditis, sepsis) and chronic purulent bronchitis - 60 100 mg / kg per day (in 2 to 4 doses). Newborns are prescribed at a rate of 15-30 mg / kg per day (in 2 divided doses), older children - 20-30 mg / kg.

The highest daily dose for adults is 6 g.

With empyema, pleura is additionally introduced into the pleural cavity of 0.25 g of the drug.

With meningitis, it is prescribed intramuscularly or intravenously - for children, 60 mg / kg per day, for adults - 1 g, every 6 hours.