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Description of the medicine: Cephalexin (Cefalexinum)

CEFALEXIN (Cefalexinum). 7 (D-a-aminophenyl-acetamido) -3-methyl-3-cephem-4-carboxylic acid monohydrate.

Synonyms: Ceporex, Baclodin, Basporin, Brisoral, Cefabiot, Cefalival, Cefax, Cefaxin, Cefibacter, Ceflon, Cephalexine, Ceporex, Efalexin, Esporin, Kefexin, Keflex, Keforal, Larixin, Paldexx, Pyxalx, Pyxalx, Pyxx, Pyxx, Pyxalx, Pyxx Sencephalin, Sepexin, Septilisin, Sintolexyn, Sporol, Talinsul, Torlasporin, Totaceprin, Ultralexine, Vapocilin, etc.

Powder with a characteristic odor, white or white with a slightly yellowish tint. It is difficult and slowly soluble in water, practically insoluble in alcohol.

Cephalexin is a first-generation cephalosporin antibiotic used internally. The drug is stable in an acidic environment; when ingested quickly (within 1, 5 - 2 hours) and is almost completely absorbed when applied on an empty stomach and somewhat slower when taken after meals. The therapeutic concentration in the blood after a single dose is maintained for 4 to 6 hours. It is excreted in significant quantities in the urine unchanged. A small part is excreted with bile. It penetrates poorly through the blood-brain barrier.

Assign with purulent-inflammatory processes of various localization; in acute and chronic pyelonephritis, cystitis, prostatitis, upper respiratory tract infections (tonsillitis, pharyngitis), pneumonia, bronchopneumonia, pleural empyema and lung abscess, etc., otitis media, sinusitis, tonsillitis, infections of the skin and soft tissues (furunculosis, pyruces, pyruces, , lymphangitis, etc.), acute and chronic osteomyelitis, gonorrhea and other diseases caused by microorganisms sensitive to the drug.

Cephalexin is prescribed orally regardless of food intake.

Take in the form of capsules, tablets and suspensions.

A single dose for adults is 0.25 - 0.5 g, daily 1 - 2 g. Children are prescribed at a rate of 25 - 50 mg / kg per day. In severe infections, the dose for adults can be increased to 4 g per day (maximum), for children - up to 100 mg / kg. The daily dose is divided into 4 doses. The duration of treatment is usually 7 to 14 days.

In case of impaired renal excretory function, the dose is reduced (due to the danger of cumulation).

To prepare the suspension, 80 ml of distilled water are added to the vial containing 2.5 g of the substance before dispensing from the pharmacy and shaken. In 1 ml of the finished suspension contains 25 mg of cephalexin. The suspension is dosed with a special spoon on which there are two labels: the bottom corresponds to 2.5 ml (62.5 mg), the top - 5 ml (125 mg).

When treating the drug, nausea, abdominal pain, and rarely diarrhea sometimes occur; allergic reactions are possible. With prolonged treatment, reversible neutropenia is possible. Dysbiosis and superinfection (candidiasis) may occur.

Urine in patients taking cephalexin can give a false positive reaction to glucose.

Contraindications for use are the same as for other cephalosporins.

Release form: in capsules of 0.25 g; tablets of 0.5 g; powder for suspensions of 2.5 g (Pulvis Serhalexini 2, 5 ro suspension) in vials.

Storage: List B. In a dry, dark place at room temperature. The aqueous suspension is stored at room temperature for no more than 6 days or in the refrigerator for no more than 14 days.