Description of the medicine: Cefalexinum (Cefalexinum)
Cefalexinum. 7 (D-a-Aminophenyl-acetamido) -3-methyl-3-cephem-4-carboxylic acid monohydrate.
Synonyms: Ceporex, Baclodin, Basporin, Brisoral, Cefabiot, Cefalival, Cefax, Cefaxin, Cefibacter, Ceflon, Cephalexine, Ceporex, Efalexin, Esporin, Kefexin, Keflex, Keforal, Larixin, Palitrex, Prindex, Pyassan, Rifalax, Rinesal, Salitex, Sencephalin, Sepexin, Septilisin, Sintolexyn, Sporol, Talinsul, Torlasporin, Totaceprin, Ultralexine, Vapocilin, and others.
White or white with a slightly yellowish tinge powder with a characteristic odor. It is difficult and slowly soluble in water, almost insoluble in alcohol.
Cephalexin is a first-generation cephalosporin antibiotic used internally. The drug is stable in an acidic environment; When ingested quickly (within 1, 5 - 2 hours) and almost completely absorbed when applied on an empty stomach and somewhat slower - when taken after a meal. The therapeutic concentration in the blood after a single dose is maintained for 4-6 hours. It is released in significant quantities with urine unchanged. A small part is excreted with bile. Poorly penetrates the blood-brain barrier.
Assign with purulent-inflammatory processes of different localization; With acute and chronic pyelonephritis, cystitis, prostatitis, infections of the upper respiratory tract (tonsillitis, pharyngitis), pneumonia, bronchopneumonia, pleural empyema and abscess of the lung, etc., otitis, sinusitis, angina, skin and soft tissue infections (furunculosis, abscesses, pyoderma , Lymphangitis, etc.), acute and chronic osteomyelitis, gonorrhea and other diseases caused by microorganisms sensitive to the preparation.
Cephalexin is administered internally, regardless of food intake.
Take in the form of capsules, tablets and suspension.
Single dose for adults is 0.25-0.5 g, daily 1 - 2 g. Children are prescribed at a rate of 25-50 mg / kg per day. In severe infection, the dose for adults can be increased to 4 g per day (maximum), for children - up to 100 mg / kg. The daily dose is divided into 4 divided doses. The duration of treatment is usually 7 to 14 days.
If the excretory function of the kidneys is impaired, the dose is reduced (because of the danger of cumulation).
To prepare the suspension, 80 ml of distilled water are added to the vial containing 2, 5 g of the substance before dispensing from the pharmacy, and shaken. In 1 ml of the finished suspension contains 25 mg cephalexin. Dosage the suspension with a special spoon, on which there are two labels: the lower one corresponds to 2, 5 ml (62, 5 mg), the upper one - 5 ml (125 mg).
Sometimes, nausea, pain in the abdomen, and diarrhea sometimes occur with the drug; Allergic reactions are possible. With prolonged treatment, reversible neutropenia is possible. Dysbacteriosis and superinfection (candidiasis) may occur.
Urine in patients taking cephalexin can give a false positive response to glucose.
Contraindications for use are the same as for other cephalosporins.
Product: in capsules of 0.25 g; Tablets of 0.5 g; Powder for suspensions of 2, 5 g (Pulvis Serhalehini 2, 5 p-p stop) in vials.
Storage: List B. In dry, the dark place at room temperature. The aqueous suspension is stored at room temperature for no longer than 6 days or in the refrigerator for no longer than 14 days.