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Medication Description: Piracetam (Pyracetamum)

PYRACETS (Pyracetamum). 2-Oxo-1-pyrrolidinyl acetamide.

Synonyms: Noothoropil, Pyramé, Apagan, Breinox, Cerebropan, Ceretran, Ciclocetam, Cintilan, Dinacel, Dinagen, Encefalux, Eumental, Euvifor, Fortineural, Gabacet, Gericetam, Merapiran, Neutrofin, Nycephrales, Nashyne, Nashyne, Nashyne, Nashyne, Nashyne, Nashyne, Nashyne, Nashyne, Nashi, Nishra, Zaram Piramem, Piratam, Pirroxil, Pyramem, Stimubral, Stimocartex, etc.

White or almost white crystalline powder. Easily soluble in water, soluble in alcohol; pH of aqueous solutions 5, 0 - 7, 0.

Piracetam is the main representative of the group of nootropic drugs. At present, a whole series of its immediate analogues and homologues (etiracetam, oxyracetam, etc.), similar in action, have been synthesized, but piracetam continues to be the main drug of this group.

Piracetam is well absorbed when taken orally. With the introduction into the body penetrates into various organs and tissues, including the brain tissue. Practically not metabolized. Excreted by the kidneys.

Piracetam has a positive effect on metabolic processes and blood circulation in the brain. Stimulates redox processes, enhances glucose utilization, improves regional blood flow in ischemic brain regions. The drug increases the energy potential of the body due to the acceleration of ATP turnover, increased adenylate cyclase activity and inhibition of nucleotide phosphatase. The improvement of energy processes under the influence of piracetam leads to an increase in the stability of brain tissue during hypoxia and toxic effects. There is evidence of amplification of nuclear RNA synthesis in the brain under the influence of piracetam.

The drug is very little toxic (in acute animal experiments, the lethal dose exceeds 10 g / kg when injected into a vein).

The therapeutic properties of piracetam are determined by its ability to improve the integrative activity of the brain, promote memory consolidation, improve learning processes, restore and stabilize impaired brain functions.

Piracetam is used in adults and children with various diseases of the nervous system, especially those associated with vascular disorders and pathologies of the brain's metabolic processes, including those in the elderly and senile age.

In neurological practice, it is prescribed for atherosclerosis of the brain, vascular parkinsonism and other diseases with symptoms of chronic cerebrovascular insufficiency, manifested in impaired memory, attention, speech, dizziness, etc., as well as changes in the cerebral circulation, with comatose and subcomatose conditions after brain injuries and intoxications, as well as during the period of rehabilitation therapy after such conditions. Piracetam is also used in diseases of the nervous system, accompanied by a decrease in intellectual and rhythmic functions and disorders of the emotional-volitional sphere.