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Description of the medicine: Cefoxitin (Cefoxitin)

Cefoxitin *. (7S) -3 - [(Carbamoyloxy) methyl] -7-methoxy-7- (2-thienylacetamido) -3-cephem-4-carboxylic acid.

Synonyms: Mefoksin (name of the drug of the company "MERKK & CO., INC.", Rahway NJ, USA.), Atralxitin, Betacef, Boncefin, Cefoctin, Cenomycin, Mefoxil, Mefoxin, Mefoxitin, Merxin, etc.

Available in the form of sodium salt.

Refers to the third generation cephalosporins. By chemical structure is close to cefuroxime.

Cefoxytin (mefoksin) is a broad-spectrum antibiotic. Effective against gram-positive and gram-negative microorganisms (aerobic and anaerobic).

It acts on Proteus of all species, Serratia, Escherichia coli, Vasteroides, Clebsiella, resistant to cephalothin. Resistant to b-lactamases. Effective against microorganisms resistant to penicillins, tetracyclines, erythromycin, chloramphenicol (levomycetin), kanamycin, gentamicin, sulfonamides.

Cefoxytin acts bactericidal by inhibiting the synthesis of the bacterial cell membrane.

Applied for the treatment of infections caused by sensitive microorganisms, including in mixed infections. The main indications for the use of cefoxitin are peritonitis and other infections of the abdominal cavity and pelvic cavity, gynecological infections, septicemia, endocarditis, urinary tract infections, gonorrhea, respiratory infections, infections of the skin, soft tissues, bones and joints. It is not used to treat meningitis.

Assign intravenously or intramuscularly. A single dose for adults is 1 - 2 g every 8 hours. In severe infections, 3 g are administered every 6 hours (up to 12 g per day). Infants and older children are administered at the rate of 20-40 mg / kg every 6-8 hours, newborns 20-40 mg / kg after 8-12 hours.

Adults and children with reduced renal function medication is prescribed in reduced doses and increases the intervals between administrations.

For intravenous injections, cefoxitin is dissolved in sterile water for injection: 1 g of the drug is dissolved first in 2 ml of water, then add 10 or 20 ml of water (in 1 or 2 g bottles) and shake until completely dissolved. Inject inject the solution for 3-5 minutes. For drip introduction, dilute the solution in an isotonic (0.9%) solution of sodium chloride or 5% glucose solution.

For intramuscular injections, dissolve 1 g of cefoxitin in 2 ml of sterile water for injection or 0.5 ml of a 1% solution of lidocaine.

Possible side effects are basically the same as with the use of other cephalosporins. With intravenous administration, thrombophlebitis may develop. With intramuscular injection, pain may occur (which is why application is recommended for dissolving the local anesthetic of lidocaine) and possibly local tissue tightening.

Cefoxytin is contraindicated in cases of hypersensitivity to cephalosporins. Do not prescribe the drug to pregnant women (insufficiently studied the risk of teratogenic effect). The drug is excreted in human milk; Use it in nursing mothers should only be in the presence of absolute indications.