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Description of the medicine: Cefoxitin (Cefoxitin)

CEFOXITIN (Cefoxitin) *. (7S) -3 - [(carbamoyloxy) methyl] -7-methoxy-7- (2-thienylacetamido) -3-cefem-4carboxylic acid.

Synonyms: Mefoxin (the name of the drug is "MERKK & CO., INC.", Rahway NJ, USA.), Atralxitin, Betacef, Boncefin, Cefoctin, Cenomycin, Mefoxil, Mefoxin, Mefoxitin, Merxin, etc.

Available in the form of sodium salt.

Refers to third generation cephalosporins. The chemical structure is close to cefuroxime.

Cefoxitin (mefoxin) is a broad-spectrum antibiotic. Effective against gram-positive and gram-negative microorganisms (aerobic and anaerobic).

It acts on Proteus of all types, Serratia, Escherichia coli, Bacteroides, Clebsiella, resistant to cephalotin. Resistant to b-lactamases. Effective against microorganisms resistant to penicillins, tetracyclines, erythromycin, chloramphenicol (chloramphenicol), kanamycin, gentamicin, sulfanilamides.

Cefoxitin acts bactericidal by inhibiting the synthesis of the membrane of a bacterial cell.

It is used to treat infections caused by microorganisms sensitive to it, including mixed infections. The main indications for the use of cefoxitin are peritonitis and other infections of the abdominal and pelvic cavities, gynecological infections, septicemia, endocarditis, urinary tract infections, gonorrhea, respiratory tract infection, skin, soft tissue, bone and joint infections. For the treatment of meningitis is not used.

Assign intravenously or intramuscularly. A single dose for adults is 1 to 2 g every 8 hours. For severe infections, 3 g is administered every 6 hours (up to 12 g per day). Infants and older children are administered at a rate of 20-40 mg / kg every 6-8 hours, for newborns 20-40 mg / kg after 8-12 hours.

For adults and children with reduced renal function, the drug is prescribed in reduced doses and the intervals between doses are increased.

For intravenous administration, cefoxitin is dissolved in sterile water for injection: 1 g of the drug is first dissolved in 2 ml of water, then 10 or 20 ml of water is added (in bottles containing 1 or 2 g of the drug) and shaken until completely dissolved. The solution is injected in a jet stream for 3-5 minutes. For drip administration, a solution is diluted in an isotonic (0.9%) sodium chloride solution or 5% glucose solution.

For intramuscular injection, 1 g of cefoxitin is dissolved in 2 ml of sterile water for injection or 0.5 ml of a 1% lidocaine solution.

Possible side effects are basically the same as when using other cephalosporins. With intravenous administration, thrombophlebitis may develop. When administered intramuscularly, pain may appear (in connection with which it is recommended to use a local anesthetic of lidocaine to dissolve) and local tissue densification is possible.

Cefoxitin is contraindicated in case of hypersensitivity to cephalosporins. The drug should not be prescribed to pregnant women (the danger of the teratogenic effect has not been studied enough). The drug is excreted in human milk; apply it to nursing mothers should only be in the presence of absolute indications.