Description drugs: Tetracycline hydrochloride (Tetracyclini hydrochloridum)
Tetracycline hydrochloride (Tetracyclini hydrochloridum).
Synonyms: Ambramycin, Amracin, Polfamycine, Tetracyclinum hydrochloricum.
Tetracycline hydrochloride is different from tetracycline (s) better solubility in water. It can be applied by intramuscular injection, for oral administration, topically, as well as inside.
Yellow crystalline powder bitter taste; soluble in 10 parts water and 100 parts of 95% alcohol.
Indications for use are the same as for tetracycline (s). For intramuscular injections usually resort for severe infectious diseases that require quick creation in the blood of high drug concentrations (sepsis, peritonitis, infectious complications in surgical patients, and others.), As well as in cases where the drug inside is difficult or impossible (vomiting, operations in the oral cavity and gastro-intestinal tract, when the patient unconscious and others.).
Injectable solution is prepared immediately before use by diluting the contents of the vial with tetracycline hydrochloride (0.1 g) in 2, 5 - 5, 0 ml sterile solution (1 - 2%) of novocaine. Injections are produced in the upper outer quadrant of the buttocks; in contact with the solution under the skin can be painful reaction.
For administration into the abdominal cavity of the vial contents were dissolved (0.1 g) in 40 ml, and for administration in the other cavity - 20 ml 0.5% novocaine solution.
A single intramuscular dose for adults 0.05 - 0.1 g (50 000 - 100 000 units). Children aged 8 - 10 years introduced 0.05 g, 10 - 14 years - to produce 0.06 g Injection 2 - 3 times a day for 5 - 7 days. If necessary to repeat the cycles at intervals of 4 - 7 days.
A single dose for oral administration (pleural, peritoneal) of 0.025 - 0.1 g
In dermatology, ENT, ophthalmic practice, the drug can be used as an ointment.
Inside designate tetracycline hydrochloride tablets in the same doses as tetracycline (s).
Possible complications and contraindications such as when applying tetracycline (s). Disorders of the gastrointestinal tract activity is somewhat less pronounced in intramuscular application of tetracycline hydrochloride.
In case of persistent infiltrates after intramuscular injection is stopped.
Method of issuance: in bottles of 0.1 g (100 000 units); film-coated tablets (red), 0.1 and 0.25 g
Storage: List B. In dry, dark place at room temperature.
Entitled "Amratsin" (Amrasin) issued abroad as an ointment for application in dermatology (3%) and ophthalmologic (1%) in the practice of the box 10 respectively, and 5 g