Description of the medicine: Tetracycline hydrochloride (Tetracyclini hydrochloridum)
TETRACYCLINE HYDROCHLORIDE (Tetracyclini hydrochloridum).
Synonyms: Ambramycin, Amracin, Polfamycine, Tetracyclinum hydrochloricum.
Tetracycline hydrochloride differs from tetracycline (base) in its best solubility in water. It can be used intramuscularly, for introduction into the cavity, topically, as well as inside.
Yellow crystalline powder of bitter taste; soluble in 10 parts of water and 100 parts of 95% alcohol.
Indications for use are the same as for tetracycline (base). Intramuscular injections are usually used for severe infectious diseases, when it is necessary to quickly create high concentrations of the drug in the blood (sepsis, peritonitis, infectious complications in surgical patients, etc.), as well as in cases where oral administration of the drug is difficult or impossible (with vomiting, operations in the oral cavity and on the gastrointestinal tract, in the unconscious state of the patient, etc.).
For injection, a solution is prepared immediately before use, diluting the contents of the vial with tetracycline hydrochloride (0.1 g) in 2, 5 - 5, 0 ml sterile solution (1 - 2%) of novocaine. Injections produce in the upper outer quadrant of the buttocks; if the solution gets under the skin, a pain reaction is possible.
For administration into the abdominal cavity, the contents of the vial (0.1 g) are dissolved in 40 ml, and for administration into other cavities, in 20 ml of a 0.5% novocaine solution.
A single dose for adults intramuscularly 0.05 - 0.1 g (50 000 - 100 000 UNITS). Children aged 8 - 10 years are administered 0.05 g, 10 - 14 years old - 0.06 g. Injections are performed 2 to 3 times a day for 5 to 7 days. If necessary, repeat cycles at intervals of 4 to 7 days.
A single dose for administration into the cavity (pleural, abdominal) is 0.025 - 0.1 g.
In dermatological, otorhinolaryngological, ophthalmic practice, the drug can be used in the form of an ointment.
Inside, tetracycline hydrochloride tablets are prescribed in the same doses as tetracycline (base).
Possible complications and contraindications are the same as when using tetracycline (base). Disorders of the gastrointestinal tract are somewhat less pronounced with intramuscular use of tetracycline hydrochloride.
In the case of persistent infiltrates after intramuscular injection, the injection is stopped.
Method of release: in vials of 0.1 g (100,000 units); coated tablets (red), 0.1 and 0.25 g.
Storage: List B. In a dry, dark place at room temperature.
Under the name Amracin (Amracin), it is produced abroad as an ointment for use in dermatological (3%) and ophthalmic (1%) practice in tubes of 10 and 5 g, respectively.