Medication Description: Doxycycline Hydrochloride (Doxycyclini hydrochloridum)
DOXYTSICLINE HYDROCHLORIDE (Doxycyclini hydrochloridum). 6-Deoxy-5-oxytetracycline hydrochloride.
Semi-synthetic derivative of oxytetracycline.
Synonyms: Apo-Doksi, Bassado, Vibramitsin, Dovitsin, Doksal, Doksibene, Doksitar, Doksilan, Doksilin, Dokst, Medomitsin, Monoklin, Novo-Doksilin, Tetradoks, Etidoxin, Unidox Solyutab, Abadox, Apo-Doss, anodes, aodes, aphrodes, anesthoids , Dovicin, Doxacin, Doxal, Doxigram, Doxilen, Doximocyn, Doxiphan, Doxybene, Doxycycline, Doxydar, Doxylan, Doxylin, Doxt, Ethidoxin, Extraciclina, Isodox, Lampodox, Medomicin, Micromicin, Minidho, anhophinina, Isodoxin, Extraciclina , Saramicina, Sincromycin, Tetradox, Unidox silutab, Vibrabiotic, Vibracina, Vibradoxil, Vibramycin, etc.
Yellow crystalline powder. Slowly dissolve in 3 parts of water. The theoretical activity of 870 units in 1 mg.
Like other tetracyclines, it is characterized by a broad spectrum of antimicrobial action. It is active against most gram-positive and gram-negative microorganisms, including those resistant to other antibiotics (with the exception of tetracyclines).
Like other tetracyclines, doxycycline also acts on rickettsia, mycoplasma, causative agents of ornithosis, psittacosis, trachoma and some protozoa. Does not affect most strains of Proteus, Pseudomonas aeruginosa, fungi, small and medium-sized viruses.
The drug is rapidly absorbed and slowly excreted from the body; depending on the dose administered, the therapeutic concentration in the blood is maintained for 18 to 24 hours. With repeated injections, the drug can be cumulated. The drug penetrates well into the organs and tissues, poorly - into the cerebrospinal fluid. Excreted in significant quantities with urine, in small quantities with feces.
Indications for use are the same as for other tetracyclines; Especially indicated for acute and chronic bronchitis, pneumonia, pleurisy, urinary tract infections, gonorrhea. There is evidence of the effectiveness of the drug in acne.
Doxycycline hydrochloride is prescribed to adults and children over 8 years old by mouth and intravenously.
With both methods of administration, the daily dose for adults on the 1st day of treatment is 0.2 g; injected simultaneously or 0.1 g after 12 hours. In the following days, a daily dose of 0.1 g (1 time per day) is used.
With severe infection, the daily dose is 1 day and the following days 0.2 g.
For children from 8 to 12 years old, the drug is prescribed at a dose of 4 mg / kg per day on the 1st day of treatment and 2 mg / kg on subsequent days (4 mg / kg for severe infections), for children over 12 years old - at a dose for adults .
Inside they take doxycycline hydrochloride after eating (to avoid) irritation of the gastric mucosa), drinking plenty of water. Do not drink milk and take at the same time preparations containing ions of calcium, magnesium, aluminum (calcium chloride, antacids, etc.).
Doxycycline hydrochloride is prescribed intravenously for severe forms of purulent-septic diseases, when it is necessary to quickly create a high concentration of antibiotic in the blood, and also if the drug is swallowed or poorly tolerated.