Description of the medicine: Doxycycline hydrochloride (Doxycyclini hydrochloridum)

Doxycycline hydrochloride (Doxycyclini hydrochloridum). 6-Deoxy-5-oxytetracycline hydrochloride.

Semisynthetic derivative of oxytetracycline.

Synonyms: Apo-Doksi, Bassado, Vibramycin, Dovitsin, Doxal, Doxibene, Doxidar, Doxilan, Doxilin, Dokst, Medomycin, Monoklin, Novo-Doksilin, Tetradox, Ethidoxine, Unidox soluteab, Abadox, Apo-Doxy, Bassado, Biociclina, Biostar , Doxicin, Doxicin, Doxal, Doxigram, Doxilen, Doximocyn, Doxipan, Doxybene, Doxycycline, Doxydar, Doxylan, Doxylin, Doxt, Ethidoxin, Extraciclina, Isodox, Lampodox, Medomicin, Micromicin, Minidox, Monocein, Monocline, Novacyclin, Novo-Doxyline , Saramicina, Sincromycin, Tetradox, Unidox silutab, Vibrabiotic, Vibracina, Vibradoxil, Vibramycin and others.

Yellow crystalline powder. Slowly soluble in 3 parts water. Theoretical activity of 870 units in 1 mg.

Like other tetracyclines it is characterized by a wide spectrum of antimicrobial action. It is active against most gram-positive and gram-negative microorganisms, including those resistant to other antibiotics (with the exception of tetracyclines).

Like other tetracyclines, doxycycline also acts on rickettsia, mycoplasma, pathogens of ornithosis, psittacosis, trachoma and some protozoa. It does not affect most proteic strains, Pseudomonas aeruginosa, fungi, small and medium viruses.

The drug is rapidly absorbed and slowly excreted from the body; Depending on the administered dose, the therapeutic concentration in the blood is maintained for 18 to 24 hours. With repeated administration, cumulation of the drug is possible. The drug penetrates well into the organs and tissues, badly - into the cerebrospinal fluid. It is excreted in considerable quantities with urine, in small quantities with feces.

Indications for use are the same as for other tetracyclines; Especially shown in acute and chronic bronchitis, pneumonia, pleurisy, urinary tract infection, gonorrhea. There are data on the effectiveness of the drug for acne.

Assign doxycycline hydrochloride to adults and children older than 8 years inside and intravenously.

With both methods of administration, the daily dose for adults is 0.2 g on the first day of treatment; Injected simultaneously or 0.1 g in 12 hours. In the following days, apply in a daily dose of 0.1 g (1 time per day).

In severe infection, the daily dose is 1 day and the next days 0.2 g.

For children from 8 to 12 years, the drug is prescribed at a dose of 4 mg / kg per day on the 1st day of treatment and 2 mg / kg on subsequent days (4 mg / kg for severe infections), children over 12 years of age - in a dose for adults .

Inside take doxycycline hydrochloride after meals (to avoid) irritation of the gastric mucosa), with plenty of water. Do not drink milk and take simultaneously drugs containing ions of calcium, magnesium, aluminum (calcium chloride, antacids, etc.).

Intravenously prescribed doxycycline hydrochloride in severe forms of purulent-septic diseases, when it is necessary to quickly create a high concentration of antibiotic in the blood, and if the intake of the drug inside is difficult or badly tolerated by the patient.

Intravenously injected drip.