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Description medications: Actilin

Neomycin sulfate (Neomycini sulfas).

Neomycin is an antibiotic complex (neomycin A, neomycin B, neomycin S) generated during the life of radiant fungus (actinomycetes) Streptomyces fradiae or related microorganisms.

Synonyms: Kolimitsin, Mitserin, Soframitsin, Framitsin, Actilin, Bykomycin, Enterfram, Framycetin , Myacine, Mycifradin, Neofracin, Neomin, Neomycinum, Nivemycin, Soframycine etc. 0-2, 6-Diamino-2, 6-dideoxy a D. -glyukopiranozil- (1-> 4) -O [0-2, 6-diamino-2, 6-dideoxy-b -L-idopiranozil- (1- 3) - b -D-ribofuranosyl (1- 5)] - 2-deoxy-D -streptamin (neomycin B).

Neomycin sulfate - a mixture of neomycin sulfate.

White or yellowish-white powder, almost odorless. The easily soluble in water, very little - in alcohol. Hygroscopic.

The theoretical activity of 680 IU in 1 mg, nearly producing activity is not less than 640 IU per 1 mg; 1 ED activity with 1 g of chemically pure neomycin B (base).

Neomycin has a broad spectrum of antibacterial action. It is effective against a number of Gram-positive (staphylococci, pneumococci, and others.) And Gram-negative (Escherichia coli, dysentery bacillus, Proteus, etc.) Microorganisms. For streptococcal maloaktiven. Pathogenic fungi, viruses and anaerobic flora is not valid. Resistance to neomycin microorganisms develops slowly and to a small extent. The drug is bactericidal.

In intramuscular neomycin quickly enters the blood; Therapeutic concentration remains in the blood for 8 to 10 hours. When administered drug absorbed poorly and almost has only local effects on the intestinal microflora.

Despite the high activity of neomycin is currently limited use because of its high nephrotoxicity and ototoksichnostyu. For parenteral administration of the drug could experience kidney failure and damage - the auditory nerve up to complete deafness. It may develop neuro-muscular conductivity.

When administered neomycin is usually toxic action is not, however, in case of violation of renal excretory function, its possible accumulation in the blood serum, which increases the risk of side effects. Moreover, in violation of the integrity of the intestinal mucosa, liver cirrhosis, uremia neomycin absorption from the intestine may increase. Through intact skin the drug is not absorbed.

Assign neomycin sulfate inside with diseases of the gastrointestinal tract caused by susceptible to the microorganism, including enteritis caused by resistant to other antibiotics, microorganisms, the operation on the digestive tract (for bowel sanitation).

Locally applied when introducing skin diseases (pyoderma, infected eczema, etc.), Infected wounds, conjunctivitis, keratitis and other eye diseases and others.

Neomycin is part of ointments << Sinalar-N >> (see.) << >> Lokakortena-H (cm.).

Inside administered in form of tablets or solutions.