Description of the medicine: Tobramycin (Tobramycinum)
O-3-amino-3-deoxy-a-D-glucose-pyranosyl- (1-> 6) -O- [2, 6-diamino-2, 3, 6 trideoxy-a-D-ribo-hexopyranosyl- (I- > 4)] -2-deoxy-D-streptamine.
Synonyms: Brulamycin, Nebcin, Obracin, Brulamycin, Distobram, Gernebcin, Nebcin, Obracin, Tobradistin, Tobrasix, etc.
An aminoglycoside antibiotic produced by Str. tenebrarius. Available in the form of sulfate.
Like other antibiotics, aminoglycosides has a wide spectrum of antibacterial action, is active against gram-positive and gram-negative microorganisms. By the degree of antibacterial activity against strains. Ps.aeruginosa is one of the most active in the series of aminoglycosides.
When administered intramuscularly, it is rapidly absorbed. The maximum concentration in blood serum is detected 30 to 40 minutes after administration. A single intravenous or intramuscular injection provides a therapeutic concentration in the body after 6-8 hours. It is excreted mainly by the kidneys, and a high concentration of the drug is noted in the urine.
Tobramycin sulfate is used for sepsis, pneumonia, purulent otitis media, empyema, pleurisy, urinary tract infections, postoperative suppuration and other infections caused by strains of pathogens sensitive to this antibiotic.
Usually, 2–5 mg / kg is administered in 2–3–4 doses intramuscularly or intravenously. The maximum daily dose for adults is 5 mg / kg (in 3 to 4 doses), for children 2 to 5 mg / kg (in 2 to 4 doses). The course of treatment is 7 to 10 days.
In case of impaired renal excretory function, the dose is reduced. According to emergency indications, the drug is administered in normal doses, but at the same time carefully monitor the function of the kidneys and the state of hearing (taking into account the nephro - and ototoxicity of the drug).
Patients with a severe course of an infectious disease are injected into a vein.
For intramuscular administration, the drug is dissolved in 2 - 5 ml of sterile water for injection, for intravenous administration - in 50 - 100 ml of isotonic sodium chloride solution or 5% glucose solution (administered dropwise over 20-60 minutes).
Tobramycin is contraindicated in case of hypersensitivity to aminoglycoside antibiotics. The drug has less nephro- and ototoxicity than gentamicin and other aminoglycosides, however, the possibility of this toxic effect must be taken into account. Tobramycin should not be prescribed simultaneously with streptomycin, other aminoglycoside antibiotics, cephaloridin, as well as with strong diuretics. Tobramycin is not prescribed in the first half of pregnancy (see also Kanamycin).
Release form: in bottles on 40; fifty; 75 and 80 mg.
Storage: in the dark place at a temperature of + 4 C.