Description of the medicine: Tobramycinum

TOBRAMYCIN (Tobramycinum).

O-3-Amino-3-deoxy-a-D-glucosopyranosyl- (1-> 6) -O- [2, 6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl- (I- > 4)] -2-deoxy-D-streptamine.

Synonyms: Brulamycin, Nebzin, Opecin, Brulamycin, Distobram, Gernebcin, Nebcin, Obracin, Tobradistin, Tobrasix and others.

Antibiotic from the aminoglycoside group, produced by Str. Tenebrarius. It is produced in the form of sulphate.

Like other antibiotics, aminoglycosides possess a wide spectrum of antibacterial action, it is active against gram-positive and gram-negative microorganisms. By the degree of antibacterial activity against strains. Ps.aeruginosa is one of the most active in the aminoglycoside series.

When intramuscular injection is rapidly absorbed. The maximum concentration in the serum is detectable 30-40 minutes after administration. A single intravenous or intramuscular injection provides a therapeutic concentration in the body after 6 to 8 hours. It is secreted mainly by the kidneys, and in the urine there is a high concentration of the drug.

Tobramycin sulfate is used in sepsis, pneumonia, purulent otitis, empyema, pleurisy, urinary tract infections, postoperative suppuration and other infections caused by susceptible antibiotic strains of pathogens.

Enter usually 2 - 5 mg / kg in 2 - 3 - 4 doses intramuscularly or intravenously. The maximum daily dose for adults is 5 mg / kg (in 3 to 4 doses), for children 2 to 5 mg / kg (in 2 to 4 doses). The course of treatment is 7-10 days.

If the excretory function of the kidneys is reduced, the dose is reduced. For emergency indications, the drug is given in usual doses, but the kidney function and hearing condition are carefully monitored (taking into account the nephro - and ototoxicity of the drug).

The vein is administered to patients with a severe course of an infectious disease.

For intramuscular injection, the drug is dissolved in 2 to 5 ml of sterile water for injection, for intravenous administration - in 50 - 100 ml of isotonic sodium chloride solution or 5% glucose solution (injected drip for 20 - 60 minutes).

Tobramycin is contraindicated in cases of hypersensitivity to aminoglycoside antibiotics. The drug has less nephro- and ototoxicity than gentamicin and other aminoglycosides, however, the possibility of this toxic effect must be taken into account. Do not use tobramycin concomitantly with streptomycin, other antibiotics-aminoglycosides, cephaloridine, and also with strong diuretics. Tobramycin is not prescribed in the first half of pregnancy (see also Kanamycin).

Product: in bottles of 40; 50; 75 and 80 mg.

Storage: in a dark place at a temperature of + 4 C.