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Description medications: Sizomitsina sulfate (Sisomycini sulfas)

SIZOMITSINA SULFATE (Sisomycini sulfas).

Salt (sulfate) aminoglycoside antibiotic formed in the process, Micromonospora inyoensis vital or other related microorganisms.

Synonyms: Extramycin, Pathomycin, Rickamysin, Siseptin , Sisomin.

White or white with a yellowish or pinkish white powder. Easily soluble in water. Applied as a 1% or 5% solution.

Sizomitsin has a broad spectrum of antimicrobial action. It is active against most Gram-positive and Gram-negative microorganisms, including staphylococci resistant to penicillin and methicillin. The spectrum of action similar to gentamicin, but more active.

Enter intramuscularly and intravenously. When injected into muscle rapidly absorbed, peak blood concentrations observed after 30 min-1 h; therapeutic concentration in the blood is stored for 8 -. At 12 h drip peak concentration observed after 15 - 30 min.

The drug does not penetrate the blood-brain barrier. Meningitis detected in cerebrospinal fluid.

Provided kidneys in unchanged form. In patients with impaired renal excretory function in the blood concentration of the drug is kept at an elevated level.

Apply sizomitsina sulfate in severe septic diseases (sepsis, meningitis, peritonitis, septic endocarditis), severe infectious and inflammatory diseases of the respiratory system (pneumonia, empyema, lung abscess), infections of the kidneys and urinary tract infections, infected burns and other diseases caused by mainly Gram-negative organisms and associations of gram-positive and gram-negative pathogens.

Enter sizomitsina sulfate injection or intravenous (drip). Single dose for adults with infections of the kidneys and urinary tract 1 mg / kg daily - 2 mg / kg (in 2 divided doses). In severe septic and infectious and inflammatory diseases of the respiratory tract, a single dose of 1 mg / kg daily - 3 mg / kg (3 hours). In severe cases, the first 2 - 3 days is administered 4 mg / kg per day (maximum dose) followed by a decrease in the dose to 3 mg / kg (in 3 - 4 divided doses). The daily dose for infants and children up to 1 year - 4 mg / kg (maximum dose of 5 mg / kg) from 1 year to 14 years - 3 mg / kg (maximum of 4 mg / kg), over 14 years old adult dose. Newborn daily dose is administered in 2 divided doses, remaining children - 3 doses. Young children the drug is prescribed only for health reasons. The duration of treatment in adults and children 7 - 10 days.

Solutions sizomitsina sulfate prepared immediately prior to administration. For intravenous drip is added to a single dose of an antibiotic for adults 50 - 100 ml of 5% glucose solution or isotonic sodium chloride solution, and 30 - 50 ml of 5% glucose solution for children. The introduction rate of an adult of 60 drops per minute, children - 8 - 10 drops per minute. Intravenous infusion prozvodyat usually within 2 - 3 days, then move on intramuscular injection.