Description of the medicine: Propanidid (Propanididum)
3-Methoxy-4- (N, N-diethylcarbamoylmethoxy) -phenylacetic acid propyl ester.
Synonyms: Sombrevin, Epontol, Fabantol, Fabontal, Propanidid, Propantan, Sombrevin.
Oily liquid of light yellow light. Insoluble in water. A special detergent (surfactant) is used for dissolution.
Propanidide - an agent for intravenous anesthesia of ultrashort action. The narcotic effect after intravenous administration develops after 20 - 40 C. The surgical stage of anesthesia lasts 3 - 5 minutes. Anesthesia occurs without a stage of excitement. Consciousness is restored 2 to 3 minutes after the end of the surgical stage of anesthesia; after 20-30 minutes the effect of the drug completely disappears.
Apply for short-term and induction anesthesia. It is convenient to use the drug for short-term operations on an outpatient basis and for diagnostic studies (biopsy, reduction of dislocations, reposition of bone fragments, removal of sutures, catheterization, bronchoscopy and bronchography, tooth extraction, etc.).
The drug is administered intravenously (slowly), usually in the same syringe with a 10 percent solution of calcium chloride, the average dose of 5-10 mg / kg. Weakened patients and the elderly are administered 3-4 mg / kg, adults in the form of a 5% solution, elderly and depleted patients, as well as children in the form of a 2.5% solution.
To prolong the action, you can repeat the injection of the drug (1-2 times); with repeated injections, the dose is reduced to 2/3 - 3/4 of the original.
There is evidence of the use of sombrevin for aqueous anesthesia for cesarean section in a dose of 10 - 12 mg / kg with simultaneous inhalation of nitrous oxide and oxygen (in a ratio of 1: 1 or 2: 1). The main anesthesia is carried out with a mixture of nitrous oxide with oxygen.
When using propanidide, hyperventilation can occur, followed by respiratory depression, tachycardia, nausea, hiccups, muscle twitching, sweating and hyperemia along the vein.
Propanidide is metabolized in the liver. Metabolism is excreted by the kidneys.
The drug is contraindicated in shock, liver damage, kidney failure. Caution is needed for violations of coronary circulation, decompensation of cardiac activity, severe hypertension.
With extreme caution and strictly individually, propanidide should be used in children under the age of 4 years and in people over 60 years of age with circulatory failure or hypertension.
Release form: 5% solution in ampoules of 10 ml (1 ml contains 50 mg of the drug), in a package of 5 and 10 ampoules.
Storage: List B.