Medication Description: Propanidid (Propanididum)
Z-methoxy-4- (N, N-diethylcarbamoylmethoxy) phenylacetic acid propyl ester.
Synonyms: Sombrevin, Epontol, Fabantol, Fabontal, Propanidid, Propantan, Sombrevin.
Oily liquid of light yellow light. Insoluble in water. A special detergent (surfactant) is used to dissolve.
Propanidide - a means for intravenous anesthesia ultrashort action. The narcotic effect after intravenous administration develops in 20-40 C. The surgical stage of anesthesia lasts 3–5 minutes. Anesthesia occurs without arousal stage. Consciousness is restored within 2 to 3 minutes after the end of the surgical stage of anesthesia; after 20-30 minutes, the effect of the drug is completely gone.
Apply for short-term and introductory anesthesia. It is convenient to use the drug for short-term operations on an outpatient basis and for diagnostic tests (biopsy, reposition of dislocations, reposition of bone fragments, removal of sutures, catheterization, bronchoscopy and bronchography, extraction of teeth, etc.).
The drug is administered intravenously (slowly), usually in the same syringe with a 10 percent solution of calcium chloride, the average dose of 5-10 mg / kg. Weakened sick and elderly people are given 3-4 mg / kg, adults - in the form of a 5% solution, the elderly and exhausted patients, as well as children - in the form of a 2.5% solution.
To prolong the action, you can repeat the injection of the drug (1-2 times); with repeated injections, the dose is reduced to 2/3 - 3/4 of the original.
There are data and the use of sombrevin for water anesthesia with caesarean section at a dose of 10 - 12 mg / kg with simultaneous inhalation of nitrous oxide and oxygen (in a ratio of 1: 1 or 2: 1). The main anesthesia is carried out with a mixture of nitrous oxide with oxygen.
When using propanidide, hyperventilation can occur, followed by respiratory depression, tachycardia, nausea, hiccups, muscle twitching, sweating, and hyperemia along the vein.
Propanidide is metabolized in the liver. Metabolism is excreted by the kidneys.
The drug is contraindicated in shock, liver damage, kidney failure. Caution is needed when violations of the coronary circulation, decompensation of cardiac activity, severe hypertension.
With extreme caution and strictly individually, propanidid should be used in children under 4 years of age and in persons older than 60 years with circulatory failure or hypertension.
Product form: 5% solution in 10 ml ampoules (1 ml contains 50 mg of the drug), in a package of 5 and 10 ampoules.
Storage: List B.