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Description medications: propanidid (Propanididum)

Propanidid (Propanididum).

H propyl-methoxy-4- (N, N- diethylcarbamoylmethoxy) - phenylacetic acid.

Synonyms: Sombrevin, Epontol, Fabantol, Fabontal, Propanidid , Propantan, Sombrevin.

Oily liquid light yellow light. Insoluble in water. Used to dissolve the special detergent (surfactant).

Propanidid - agent for intravenous anesthesia ultrashort action. Drug effect after intravenous develops within 20 - 40 C. Surgical stage anesthesia lasts 3 - 5 min. Anesthesia is incurred without the stage of initiation. Consciousness is recovering after 2 - 3 minutes after the end of the surgical stage of anesthesia; 20 - 30 minutes full effect of the drug takes place.

Apply for short-term and induction of anesthesia. The drug is useful when short-term operations on an outpatient basis, and diagnostic tests (biopsy, reduction of dislocation, repositioning bone fragments, removing stitches, catheterization, bronchoscopy and bronchography, extractions, etc..).

Preparation is administered intravenously (slowly), typically a syringe with 10 percent solution of calcium chloride, the average dose of 5.10 mg / kg. Debilitated patients and elderly people administered 3 - 4 mg / kg, adult - in the form of a 5% solution, the elderly and malnourished patients, and children - in the form of a 2.5% solution.

To extend the action can be repeated injections of the drug (1 to 2 times); when repeated injections the dose is reduced to 2/3 - 3/4 of the original.

And the data available for use sombrevina aqueous anesthetic caesarean section at a dose of 10 - 12 mg / kg with simultaneous inhalation of nitrous oxide and oxygen (ratio 1: 1 or 2: 1). The basic mixture is carried anesthesia with nitrous oxide in oxygen.

When using propanidid hyperventilation may occur, followed by respiratory depression, tachycardia, nausea, hiccups, muscle twitching, sweating and redness along the vein.

Propanidid metabolized in the liver. The metabolic products excreted by the kidneys.

The drug is contraindicated in shock, liver damage, kidney failure. Caution is needed in violation of the coronary circulation, cardiac dekompenstsatsii expressed hypertension.

With the utmost care and strictly individual, should be used propanidid in children younger than 4 years of age and persons over 60 years with circulatory failure or hypertension.

Product: 5% solution in ampoules of 10 ml (1 ml contains 50 mg) in a package of 5 and 10 ampoules.

Storage: List B.