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Description of the medicine: Sodium oxybutyrate (Natrii oxybutyras)

SODIUM OXIBUTIRATE (Natrii oxybutyras).

Sodium salt of g-hydroxybutyric acid.

Synonyms: Natrium oxybutyricum, Oxybate sodium.

White or white with a weak yellowish tinge crystalline powder with a weak specific smell. Easily soluble in water. Soluble in alcohol. Hygroscopic. Aqueous solutions (PH 7, 7 - 8, 7) are sterilized at + 100 ° C for 30 minutes.

By chemical structure and pharmacological properties - hydroxybutyric acid (GHB) is close to g - aminobutyric acid (GABA).

Unlike aminalone (GABA), sodium oxybutyrate easily penetrates into the central nervous system.

The drug has elements of nootropic activity. Characteristic is its pronounced antihypoxic effect; It increases the resistance of the body, including brain tissue, heart, as well as the retina of the eye, to oxygen deficiency. The drug has a sedative and central muscle relaxant effect, in large doses causes sleep and a state of anesthesia. Analgesic influence, he does not have, but enhances the action of analgesic, as well as narcotic drugs. It is also characterized by anti-shock action.

Sodium oxybutyrate is used in anesthetic practice as a non-inhaling narcotic for narcosis in case of malignant low-traumatic surgeries with the preservation of spontaneous breathing, as well as for introductory and basic anesthesia in surgery, obstetrics and gynecology, especially in patients undergoing hypoxia; In pediatric surgery; When carrying out anesthesia in the elderly. In ophthalmic practice, sodium oxybutyrate is used in patients with primary open-angle glaucoma (along with specific therapy) to activate oxidative processes in the retina and to improve vision in this regard.

In psychiatric and neurological practice, sodium oxybutyrate is used in patients with neurotic and neurosis-like conditions, with intoxications and traumatic injuries of the central nervous system, in sleep disorders, in narcolepsy (to improve night sleep).

There is sodium oxybutyrate in relatively large doses.

For general anesthesia, sodium oxybutyrate is used intravenously, intramuscularly, orally.

Intravenously injected physically strong people and excitable patients at a rate of 70 - 120 mg per 1 kg of body weight; Weakened patients - 50 70 mg / kg. The preparation is dissolved in 50-100 ml of 5% (sometimes 40%) glucose solution or a ready-made 20% aqueous solution in ampoules is used. Enter slowly (1 - 2 ml per minute); After 5-7 minutes after the start of the drug, the patient falls asleep. You can also enter sodium oxybutyrate at a rate of 35-40 mg / kg in a mixture with 4-6 mg / kg thiopental sodium (for 1 to 2 minutes). The onset of the drug status occurs after 4 to 6 minutes, then sodium narcobutyrate is added at a rate of 40 mg / kg to deepen anesthesia. The surgical stage of anesthesia occurs 30 to 40 minutes after the administration of the drug. The duration of anesthesia 2 - 4 hours.