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Description medications: oleandomycin phosphate (Oleandomycini phosphas)

Oleandomycin PHOSPHATE (Oleandomycini phosphas).

Oleandomycin is an antibiotic produced by the fungus Streptomyces antibioticus radiant or other related microorganisms.

It refers to a group of antibiotics, macrolides. The molecule consists of amino sugar oleandomitsina Desosaminyl and neutral sugar L-oleandrosyl associated with lactone glucoside - oleandolidom.

Synonyms: Amimycin, Cyclamycin, Matrimycin, Matromycin , Oleandocyn, Oleandomycin, Oleandomycinum phosphoricum, Romicil, Romycil and others.

Crystalline powder or porous mass of white or white with a yellowish tinge color, bitter taste. The easily soluble in water, soluble in dilute acid solutions, is readily soluble in alcohols. Hygroscopic.

Activity oleandomitsina phosphate is expressed in units (U). At 1 mg product contains at least 750 IU; 1 U is the activity of 1 ug oleandomitsina base.

Oleandomycin inhibits the growth and development of Gram-positive (staphylococci, streptococci, pneumococci, diphtheria bacillus et al.) And some Gram (gonococci, meningococci, etc.) Bacteria and large viruses and rickettsiae. Maloaktiven against E. coli and other gram-negative enteric bacteria. Stafilikokkov active against resistant to penicillin and other antibiotics. Sometimes the effect on pathogens that are resistant to erythromycin. At therapeutic doses, it acts bacteriostatic.

Oleandomycin is well absorbed when taken orally, quickly penetrates into many organs and body fluids. Through the intact blood-brain barrier does not pass.

Apply oleandomiditsa phosphate for the treatment of pneumonia, pleurisy, lung abscess, empyema, bronchiectasis, tonsillitis, otitis media, prolonged endocarditis, meningitis, sepsis (staphylococcal, streptococcal and pneumococcal), osteomyelitis, abrasions, gonorrhea, enterocolitis, infections of the urinary and biliary tract (if is intact liver parenchyma) and other diseases caused by microorganisms susceptible to this antibiotic and resistant to other antibiotics.

Due to the fact that microflora in the treatment of oleandomycin, particularly Staphylococcus can rapidly acquire resistance to it, it is often combined with other antibiotics, especially tetracycline (see. Oletetrin).

Assign inside after eating.

The average single dose for adults, 0.25 g (250 000 units). Take every 4 - 6 hours.

Higher doses for adults: single 0.5 g daily 2 grams higher daily doses for children: under 3 years - 0.02 g / kg (20 mg = 20 000 units), from 3 to 6 years old - 0.25 - 0.5 g (250 000 - 500 000 units), from 6 to 14 years - 0.5 - 1, O g, over 14 years - 1 0 - 1, 5 g daily dose divided into 4 - 6 receptions.

The total dose and duration of treatment depends on the nature and course of the disease, the efficacy and tolerability of the drug. After the termination of the acute symptoms of the disease, continue to use the drug for the next 48 hours The average duration of treatment of 5 -. 7 days.

Oleandomycin phosphate is generally well tolerated. In some cases, there is nausea, vomiting, diarrhea.