Description of the medicine: Lincomycin hydrochloride (Lyncomycini hydrochloridum)
LINKOMICINE HYDROCHLORIDE (Lyncomycini hydrochloridum).
Lincomycin is an antibiotic produced by Streptomyces lincolniensis or other related actinomycetes.
Synonyms: Nelorene, Albiotic, Cillimycin, Lincocin, Lincolnensin, Liocin, Mycivin, Neloren and others.
Produced in the form of monohydrate. White or almost white crystalline powder, bitter to the taste. Easily soluble in water, hard - in alcohol.
Lincomycin is similar in antibacterial action to the antibiotics of the macrolide group, although it differs from them in chemical structure. It inhibits the synthesis of proteins in microorganisms, has bacteriostatic or bactericidal action depending on the concentration in the body and the sensitivity of microorganisms. Effective against gram-positive microorganisms (staphylococcus, streptococcus, pneumococcus, diphtheria rods) and some anaerobes, including pathogens and tetanus. It is also active against mycoplasmas. Gram-negative bacteria, fungi and viruses do not work. It is active against microorganisms, especially staphylococci, resistant to other antibiotics. The resistance of microorganisms to lincomycin is slow.
In therapeutic doses, the drug acts bacteriostatically. The mechanism of action is associated with the suppression of protein synthesis by bacterial cells.
After ingestion and intramuscular injection, lincomycin is rapidly absorbed, enters various organs and tissues, including bone tissue. It is difficult to penetrate the blood-brain barrier, but permeability increases with meningitis.
Lincomycin is used in the treatment of septic conditions caused by staphylococci and streptococci, with acute and chronic osteomyelitis, pneumonia, purulent infections of the skin and soft tissues, erysipelas, otitis and other infections caused by microorganisms sensitive to this antibiotic, especially in infections caused by microorganisms resistant to Penicillins and other antibiotics, as well as allergies to penicillins.
Due to the fact that lincomycin accumulates in the bone tissue, it is one of the most effective drugs in the treatment of acute and chronic osteomyelitis and other infectious bone lesions, as well as joints (see also Fusidine-sodium).
Apply lincomycin hydrochloride intramuscularly, intravenously, orally as well as topically.
The daily dose for adults with parenteral administration is 1, 8 g, single - 0.6 g. In severe infection, the daily dose can be increased to 2, 4 g. The drug is administered 3 times a day at intervals of 8 hours. Children are prescribed in Daily dose of 10 - 20 mg / kg regardless of age.
Intramuscularly, lincomycin hydrochloride is administered only at a drop rate of 60 to 80 drops per minute. Before the introduction of 2 ml of a 30% solution of antibiotic (0.6 g) is diluted with 250 ml of isotonic sodium chloride solution.
The duration of treatment is 7 to 14 days, with osteomyelitis treatment up to 3 weeks or more.