Description of the medicine: Lincomycin hydrochloride (Lyncomycini hydrochloridum)
LINCOMICINE HYDROCHLORIDE (Lyncomycini hydrochloridum).
Lincomycin is an antibiotic produced by Streptomyces lincolniensis or other related actinomycetes.
Synonyms: Neloren, Albiotic, Cillimycin, Lincocin, Lincolnensin, Liocin, Mycivin, Neloren, etc.
Available as monohydrate. White or almost white crystalline powder, bitter in taste. Easily soluble in water, difficult to alcohol.
Lincomycin is similar in antibacterial action to antibiotics of the macrolide group, although it differs from them in chemical structure. It inhibits the synthesis of proteins in microorganisms, has a bacteriostatic or bactericidal effect, depending on the concentration in the body and the sensitivity of microorganisms. Effective against gram-positive microorganisms (staphylococci, streptococci, pneumococci, diphtheria coli) and some anaerobes, including pathogens of gas gangrene and tetanus. It is also active against mycoplasmas. Gram-negative bacteria, fungi and viruses are not affected. Active against microorganisms, especially staphylococci resistant to other antibiotics. The resistance of microorganisms to lincomycin is produced slowly.
In therapeutic doses, the drug acts bacteriostatically. The mechanism of action is associated with the suppression of protein synthesis by bacterial cells.
After ingestion and intramuscular administration, lincomycin is rapidly absorbed, enters various organs and tissues, including bone tissue. It is difficult to penetrate the blood-brain barrier, but permeability increases with meningitis.
Lincomycin is used in the treatment of septic conditions caused by staphylococci and streptococci, with acute and chronic osteomyelitis, pneumonia, purulent infections of the skin and soft tissues, erysipelas, otitis media and other infections caused by microorganisms sensitive to this antibiotic, especially when infections are caused by microorganisms that are resistant to penicillins and other antibiotics, as well as allergies to penicillins.
Due to the fact that lincomycin accumulates in bone tissue, it is one of the most effective drugs in the treatment of acute and chronic osteomyelitis and other infectious lesions of bones and joints (see also Fusidin-sodium).
Apply lincomycin hydrochloride intramuscularly, intravenously or orally and also locally.
The daily dose for adults with parenteral administration is 1.8 g, a single dose is 0.6 g. In severe cases of infection, the daily dose can be increased to 2.4 g. The drug is administered 3 times a day at intervals of 8 hours. Children are prescribed a daily dose of 10 to 20 mg / kg, regardless of age.
Lincomycin hydrochloride is administered intravenously only at a rate of 60 to 80 drops per minute. Before administration, 2 ml of a 30% antibiotic solution (0.6 g) is diluted with 250 ml of isotonic sodium chloride solution.
The duration of treatment is 7-14 days, with osteomyelitis, the course of treatment is up to 3 weeks or more.