Description of the medicine: Ristomycin sulfate (Ristomycini sulfas)
RISTOMYCIN SULPHATE (Ristomycini sulfas).
Ristomycin is an antimicrobial substance produced by Proactinomyces fructiveri var. ristomycini.
Synonyms: Ristocetin, Spontin.
Ristomycin sulfate is an odorless powder or creamy porous mass. Soluble in water.
The drug inhibits the development of gram-positive microorganisms (staphylococci, streptococci, pneumococci), listeria, spore gram-positive rods, many anaerobes and acid-resistant bacteria. Gram-negative bacteria and fungi do not act. Active against staphylomycetin, tetracycline, neomycin and other antibiotics.
The activity of the drug is expressed in units of action (ED). Theoretical activity of 960 U / mg, practical - at least 800 U / mg.
When taken orally, the drug is practically not absorbed. When administered intravenously, it quickly penetrates into various organs and tissues. The main part of the drug is excreted in the urine during the first 3 hours after administration.
It is mainly used for severe septic diseases caused by gram-positive microorganisms, especially staphylococci resistant to other antibiotics: septic endocarditis, staphylococcal, streptococcal and pneumococcal sepsis, hematogenous osteomyelitis, purulent meningitis and other non-severe coccidi.
Ristomycin sulfate is administered only intravenously. Subcutaneous administration is irritating.
The daily dose for adults is 1,000,000 - 1,500,000 units, for children - 20,000 - 30,000 units per 1 kg of body weight; administered in 2 doses at intervals of 12 hours
The drug is dissolved in 30-40 ml of a sterile isotonic sodium chloride solution or 5% glucose solution and slowly injected into a vein. You can also enter drip by dissolving 250,000 IU of the drug in 125 ml, and 1 000 000 IU in 500 ml of isotonic sodium chloride solution.
At the end of the infusion, 10-20 ml of isotonic sodium chloride solution should be introduced without removing the needle (for washing the veins and preventing the development of phlebitis).
The duration of treatment is determined by the course of the disease. With pneumococcal and streptococcal diseases, treatment usually lasts at least 5 to 7 days. In acute and subacute bacterial endocarditis caused by staphylococci or enterococci, the course of treatment is 14 to 20 days (up to 30 days), and the drug is prescribed 500,000 - 750,000 units 2 times a day.
The introduction of ristomycin sulfate (mainly in the early days) may be accompanied by chills, sometimes nausea. Caution must be exercised in the treatment of patients with sepsis with the phenomena of oliguria and anuria; to normalize the relative density of urine, the drug is administered in reduced doses - 250,000 units after 48 hours.
During treatment, it is necessary to monitor renal function, conduct blood tests. Some patients may have leukopenia and neutropenia.
In case of allergic reactions, antihistamines are used.