Medication Description: Ristomycin Sulfate (Ristomycini sulfas)
RISTOMICIN SULFATE (Ristomycini sulfas).
Ristomycin is an antimicrobial substance produced by Proactinomyces fructiveri var. ristomycini.
Synonyms: Ristocetin, Spontin.
Ristomycin Sulfate is an odorless powder or porous cream colored mass. Soluble in water.
The drug inhibits the development of gram-positive microorganisms (staphylococci, streptococci, pneumococci), Listeria, spore gram-positive bacilli, many anaerobes and acid-resistant bacteria. It does not affect gram-negative bacteria and fungi. Active against stafilomitsitinu, tetracycline, neomycin and other antibiotics.
The activity of the drug is expressed in units of action (ED). The theoretical activity of 960 U / mg, practical - at least 800 U / mg.
When administered, the drug is practically not absorbed. When administered intravenously, it quickly penetrates into various organs and tissues. The main part of the drug is excreted in the urine during the first 3 hours after administration.
It is used mainly in severe septic diseases caused by gram-positive microorganisms, especially staphylococci that are resistant to the action of other antibiotics: septic endocarditis, staphylococcal, streptococcal and pneumococcal sepsis, hematogenous osteomyelitis, and purulent meningitis.
Ristomycin Sulfate is administered only intravenously. Subcutaneously irritating.
The daily dose is for adults 1 000 000 - 1 500 000 IU, for children - 20 000 - 30 000 IU per 1 kg of body weight; administered in 2 doses with an interval of 12 hours
The drug is dissolved in 30 - 40 ml of sterile isotonic solution of sodium chloride or 5% glucose solution and slowly injected into a vein. You can also enter drip, dissolving 250 000 IU of the drug in 125 ml, and 1 000 000 IU in 500 ml of isotonic sodium chloride solution.
At the end of the infusion, you should, without removing the needle, inject 10 to 20 ml of isotonic sodium chloride solution (to wash the vein and prevent the development of phlebitis).
The duration of treatment is determined by the course of the disease. In pneumococcal and streptococcal diseases, treatment usually lasts at least 5-7 days. For acute and subacute bacterial endocarditis caused by staphylococci or enterococci, the course of treatment is 14-20 days (up to 30 days), and the drug is prescribed in 500,000-750,000 units 2 times a day.
Introduction of ristomycin sulfate (mainly in the early days) may be accompanied by chills, sometimes nausea. Care must be taken when treating patients with sepsis with signs of oliguria and anuria; until normalization of the relative density of urine, the drug is administered in reduced doses - 250 000 units in 48 hours.
During treatment, it is necessary to monitor the function of the kidneys, to conduct blood tests. In some patients, leukopenia and neutropenia are possible.
In the case of the development of allergic reactions apply antihistamine drugs.