Description medications: ristomycin sulfate (Ristomycini sulfas)
Ristomycin SULFATE (Ristomycini sulfas).
Ristomycin - antimicrobial substance produced by Proactinomyces fructiveri var. ristomycini.
Synonyms: Ristocetin, Spontin.
Ristomycin sulfate is a powder or a porous mass of cream-colored odorless. Soluble in water.
The drug inhibits the development of Gram-positive microorganisms (staphylococci, streptococci, pneumococci), Listeria, spore-forming Gram-positive rods, many anaerobes, and acid-fast bacilli. In Gram-negative bacteria and fungi are not active. Active against stafilomitsetinu, tetracycline, neomycin, and other antibiotics.
Drug activity is expressed in units (U). The theoretical activity of 960 U / mg, the practical - not less than 800 IU / mg.
When administered drug is practically not absorbed. When intravenously quickly penetrate into different organs and tissues. The bulk of the drug is excreted in the urine within the first 3 hours after administration.
Applied mainly in severe septic diseases caused by Gram-positive microorganisms, especially staphylococci resistant to other antibiotics: septic endocarditis, staphylococcal, streptococcal and pneumococcal sepsis, hematogenous osteomyelitis, purulent meningitis and other severe infections cocci, is not treatable with other antibiotics.
Ristomycin sulfate administered only intravenously. When administered subcutaneously irritant.
The daily dose for adults is 1 000 000 - 1 500 000 IU for children - 20,000 - 30,000 units per 1 kg of body weight; in 2 doses administered with an interval of 12 hours.
The drug is dissolved in 30 - 40 ml of sterile isotonic sodium chloride solution or 5% glucose solution and slowly administered intravenously. You can also enter drip solution of 250 000 units of the drug in 125 ml and 1 million units - 500 ml of isotonic sodium chloride solution.
At the end of the infusion should be without removing the needle enter 10 - 20 ml of isotonic sodium chloride solution (for washing vein phlebitis and prevention of the development).
Duration of treatment is determined by the course of the disease. When pneumococcal and streptococcal diseases, treatment usually lasts for at least 5 - 7 days. In acute and subacute bacterial endocarditis caused by staphylococci and enterococci, treatment is 14 - 20 days (30 days), the drug is prescribed 500 000 - 750 000 IU, 2 times a day.
Introduction ristomycin sulfate (mainly in the early days) may be accompanied by fever, and sometimes nausea. Caution should be exercised when treating patients with symptoms of sepsis, oliguria and anuria; to normalize the relative density of urine, the drug is administered in small doses - 250 000 units in 48 hours.
During treatment it is necessary to monitor kidney function, carry out blood tests. Some patients may leukopenia and neutropenia.
In case of allergic reactions used protivogistaminnye drugs.