Medication Description: Pantogamum
Calcium salt D - (+) - a, g - dioxy- b, b - dimelbutyryl- - aminobutyric acid, or calcium salt D - (+) - homopanthenic acid.
Synonyms: Calcium homopantothenat, Hopaten.
The corresponding acid is named Acidum homopantenicum, Homopantothenic acid, HOPA, Hopatenic acid, Hopate.
White crystalline powder. Easily soluble in water, very slightly soluble in alcohol; pH 5% aqueous solution 7, 0 - 9, 0.
According to the chemical structure, pantogues can be considered as a modified pantothenic acid molecule (see), including the GABA residue, which replaces the α-alanine fragment.
In terms of pharmacological properties, pantogam also has elements of similarity with GABA and pantothenic acid.
The drug has elements of nootropic activity, improves metabolic processes, increases the body's resistance to hypoxia, has an anticonvulsant effect, prolongs the effect of barbiturates, reduces the response to pain stimuli. It has no significant effect on the bioelectrical activity of the brain, on the peripheral adreno-and cholinergic systems, characterized by a short-term moderate hypotensive effect. The drug is low toxic.
In a clinical study, it was found that pantogam improves the condition of patients with cerebral insufficiency of exogenous-organic genesis, reduces motor excitability, activates mental activity and physical performance. It is also effective in hyperkinetic disorders, Jacksonian epilepsy, parkinsonism, tremor, in neuroleptic syndrome, the clonic form of stuttering in children.
Pantogam is used in children with mental deficiency, oligophrenia, with delayed speech development, and also (in combination therapy, and sometimes independently) with epilepsy, especially with polymorphic seizures or small epileptic seizures.
There is evidence of the effectiveness of pantogam (reduction of pain) in the trigeminal neuralgia (see also Sodium hydroxybutyrate).
Pantogam is also prescribed in combination with anticonvulsant drugs for epilepsy with symptoms of inhibition, for neuroinfections and for craniocerebral injuries.
Applied also with subcortical hyperkinesis, including (as a corrector) with neuroleptic extrapyramidal syndrome. With the preventive purpose can be administered simultaneously with antipsychotic agents.
Accept pantogam inside (in 15 - 30 min. After food). A single dose for adults is usually 0.5 - 1 g, for children - 0.25 - 0.5 g. The daily dose for adults is 1, 5 - 3 g, for children - 0.75 - 3 g. The course of treatment continues from 1 to 4 months (sometimes up to 6 months). After a 3-6 month break, it is possible to repeat the course of treatment.
Children with mental deficiency appoint 0.5 g 4 - 6 times a day. The course of treatment is on average 3 months.
When epilepsy is used (in combination with specific antiepileptic drugs) in children, 0.25 - 0.5 g 3 - 4 times a day, in adults, 0.5 - 1 g 3 - 4 times a day.