Description of the medicine: Pantogamum (Pantogamum)
The calcium salt of D - (+) - a, g - dioxi-b, b - dimelbutyryl - - aminobutyric acid, or the calcium salt of D - (+) - homopantothenic acid.
Synonyms: Calcium homopantothenat, Hopaten.
The corresponding acid has the names: Acidum homopantenicum, Homopantothenic acid, HOPA, Hopatenic acid, Hopate.
White crystalline powder. Easily soluble in water, very slightly soluble in alcohol; pH of a 5% aqueous solution of 7, 0 - 9, 0.
According to the chemical structure, pantogam can be considered as a modified pantothenic acid molecule (see), including the GABA residue, which replaces the α-alanine fragment.
According to the pharmacological properties, pantogam also has elements of similarity with GABA and pantothenic acid.
The drug has elements of nootropic activity, improves metabolic processes, increases the body's resistance to hypoxia, has an anticonvulsant effect, lengthens the effect of barbiturates, and reduces reactions to painful irritations. It does not have a noticeable effect on the bioelectric activity of the brain, on peripheral adrenergic and cholinergic systems, and is characterized by a short-term moderate hypotensive effect. The drug is low toxic.
A clinical study found that pantogam improves the condition of patients with cerebral insufficiency of exogenous organic origin, reduces motor excitability, activates mental activity and physical performance. It is also effective in hyperkinetic disorders, Jacksonian epilepsy, parkinsonism, tremor, with antipsychotic syndrome, and the clonic form of stuttering in children.
Pantogamum is used in children with mental deficiency, oligophrenia, with a delay in the development of speech, and also (in complex therapy, and sometimes alone) with epilepsy, especially with polymorphic seizures or small epileptic seizures.
There is evidence of the effectiveness of pantogam (reduction of pain) in trigeminal neuralgia (see also Sodium hydroxybutyrate).
Pantogam is also prescribed in combination with anticonvulsants for epilepsy with the phenomena of lethargy, with neuroinfections and traumatic brain injuries.
They are also used for subcortical hyperkinesis, including (as a corrector) for neuroleptic extrapyramidal syndrome. For preventive purposes, it can be prescribed simultaneously with antipsychotics.
Pantogam is taken orally (15-30 minutes after eating). A single dose for adults is usually 0.5 - 1 g, for children - 0.25 - 0.5 g. The daily dose for adults is 1, 5 - 3 g, for children - 0.75 - 3 g. The course of treatment continues from 1 to 4 months (sometimes up to 6 months). After a 3-6 month break, a second course of treatment is possible.
Children with mental deficiency are prescribed 0.5 g 4-6 times a day. The course of treatment is an average of 3 months.
For epilepsy, it is used (in combination with specific antiepileptic drugs) in children, 0.25-0.5 g 3-4 times a day, in adults 0.5-1 g 3-4 times a day.