Description of the medicine: Streptocidum (Streptocidum)
STREPTOCID (Streptocidum). para-aminobenzenesulfamide.
Synonyms: White Streptocide, Ambesid, Deseptyl, Dipron, Prontalbin, Prontalin, Prontoin, Prontosil album, Streptamin, Streptocidum album, Streptozol, Sulfamidyl, Sulfanilamide, Sulfanilamidum, Sulphanilamide, etc.
Flavourless white crystalline powder. Slightly soluble in water (1: 170), easy in boiling water, difficult in alcohol (1:35), soluble in caustic alkali solutions.
It has an antimicrobial effect against streptococci, meningococci, gonococci, pneumococci, Escherichia coli and some other bacteria.
When introduced into the body, streptocide is rapidly absorbed. The highest concentration of the drug in the blood is created 1 - 2 hours after administration. After 4 hours, it is detected in the cerebrospinal fluid. It is allocated mainly (90 - 95%) by kidneys.
Apply streptocide for the treatment of tonsillitis, erysipelas, cystitis, pyelitis, enterocolitis, for the prevention and treatment of wound infections and other infectious diseases.
Assign inside to adults at 0.5 - 1, 0 g 5 - 6 times a day, only 3 - 6 g per day; children under the age of 1 year - 0.05 - 0.1 g per reception from 2 to 5 years - 0.2 - 0.3 g, from 6 to 12 years old - 0.3 - 0.5 g. With an unconscious state and vomiting, you can replace the appointment of the drug inside by injecting soluble streptocide into the muscles, under the skin or into a vein.
Higher doses for adults inside: single 2 g, daily 7 g.
With superficial infectious diseases of the skin and mucous membranes of the nasal cavity and ear, with burns, ulcers, etc. apply streptocide in the form of an ointment (10%) or liniment (5%). In case of deep wounds, streptocide is introduced into the wound cavity in the form of a carefully ground sterilized powder (5 - 10 - 15 g); at the same time, sulfonamide (or other antibacterial) drugs are prescribed orally.
In a mixture with norsulfazole, penicillin and ephedrine, streptocide is sometimes used for acute rhinitis; the powder is blown into the nasal cavity using a special powder blower or drawn into the nose when inhaling (see also Ointment “Sunoref”).
When taking streptocide, headache, dizziness, nausea, and vomiting are sometimes noted; cyanosis may develop.
Taking large amounts of the drug can cause changes in the hematopoietic system (leukopenia, agranulocytosis), sometimes in the nervous and cardiovascular systems (paresthesia, tachycardia), as well as dermatitis, diarrhea. In the urinary apparatus, when taking streptocide, complications are rare.
Recently, instead of streptocide, sulfadimesin, etazole and other more effective sulfanilamide drugs are being used more and more, causing fewer side effects.
Contraindications to treatment with streptocide are diseases of the hematopoietic system, nephrosis, nephritis, and bazedova disease. With prolonged treatment with streptocide, blood tests should be periodically performed.
Method of release: powder; tablets of 0.3 and 0.5 g in a package of 10 pieces; 10% ointment; 5% liniment.
Storage of powder and tablets: List B. In a well-closed container.
Streptocid ointment (Unguentum Streptocidi). Contains 10 g of streptocide and 90 g of petroleum jelly (per 100 g of 10% ointment). The ointment is white or light yellow.