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Description of drug: Norsulfazole (Norsulfazolum)

NORSULFAZOL (Norsulfazolum). 2- (p-Aminobenzenesulfamido) -thiazole.

Synonyms: Amidotiazol, Aseptosil, Azoseptale, Cibazol, Eleudron, Poliseptil, Pyrisulfon, Sulfathiazole, Sulphathiazolum, Thiazamide and others.

White or white with a slightly yellowish tinge crystalline powder odorless. Very little soluble in water, little - in alcohol, soluble in dilute mineral acids and solutions of caustic and carbonic acid.

Norsulfazole is effective in infections caused by hemolytic streptococcus, pneumococcus, gonococcus, staphylococcus, and E. coli.

The drug is easily absorbed from the gastrointestinal tract and quickly excreted from the body. It is excreted mainly with urine, mainly in a free, non-acetylated form.

Applied internally with pneumonia, meningitis, staphylococcal and streptococcal sepsis and other infectious diseases. For pneumonia and meningitis, adults are prescribed 2 g for the first dose, then 1 g every 4 to 6 hours before the body temperature decreases; In the future take 1 g in 6 - 8 hours. In total for the course of treatment the patient takes 20 - 300 g of the drug. With staphylococcal infections at the first reception appoint 3 - 4 g, and then 1 g 4 times a day. The course of treatment lasts 3 to 6 days. In patients with dysentery, the drug is administered in the same way as sulfadimezine (see).

To children, norsulfazole is prescribed every 4 to 6 to 8 hours in the following single doses: between 0.1 and 0.25 g between the ages of 4 months and 2 years, from 0.3 to 0.4 g from 2 to 5 years, from 6 to 12 years - 0.4-0.5 g. The first dose is given a double dose.

Higher doses for adults inside: single 2 g, daily 7 g.

When using norsulfazole, it is recommended to maintain a strong diuresis (introduction of 2 to 3 liters of liquid per day into the body: after each intake of the drug 1 cup of water is added with the addition of 1/2 teaspoon of sodium bicarbonate or a glass of Borjomi).

The drug is usually well tolerated, but nausea is possible, in rare cases - vomiting.

In connection with the emergence of more effective chemotherapeutic agents, the use of norsulfazole is relatively limited.

Form release: powder; Tablets of 0.25 and 0.5 g in a package of 10 pieces.

Storage: List B. In a well ukuporennoy container.