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Medication Description: Norsulfazolum

NORSULFAZOL (Norsulfazolum). 2- (p-Aminobenzene sulphamido) -thiazole.

Synonyms: Amidotiazol, Aseptosil, Azoseptale, Cibazol, Eleudron, Poliseptil, Pyrisulfon, Sulfathiazole, Sulfphiazolum, Thiazamide, etc.

White or white with a slightly yellowish white crystalline powder; odorless. Very little soluble in water, a little - in alcohol, soluble in diluted mineral acids and solutions of caustic and carbonic alkalis.

Norsulfazol is effective for infections caused by hemolytic streptococcus, pneumococcus, gonococcus, staphylococcus, and Escherichia coli.

The drug is easily absorbed from the gastrointestinal tract and is rapidly excreted from the body. Excreted mainly in the urine, mainly in the free, non-acetylated form.

Apply inside with pneumonia, meningitis, staphylococcal and streptococcal sepsis and other infectious diseases. With pneumonia and meningitis, adults are prescribed for the first intake of 2 g, then 1 g every 4 to 6 hours until the body temperature decreases; in the future, take 1 g every 6 to 8 hours. In total, the patient takes 20 - 30 G of the drug for the course of treatment. In case of staphylococcal infections, 3–4 g are prescribed at the first dose, and then 1 g 4 times a day. The course of treatment lasts 3 to 6 days. Patients with dysentery are prescribed the same way as sulfadimezin (see).

Children norsulfazol appoint every 4 - 6 - 8 h in the following single doses: at the age of 4 months to 2 years - at 0.1 - 0.25 g, from 2 to 5 years at 0.3 - 0.4 g, from 6 to 12 years - at 0.4 - 0.5 g. At the first dose give a double dose.

Higher doses for adults inside: single 2 g daily 7 g.

When norsulfazole is used, it is recommended to maintain enhanced diuresis (administration of 2–3 l of liquid per day: after each drug intake, drink 1 cup of water with ½ tsp of sodium bicarbonate or a glass of borjom).

The drug is usually well tolerated, but nausea is possible, in rare cases, vomiting.

Due to the emergence of more effective chemotherapeutic agents, the use of norsulfazole is relatively limited.

Method of issuance: powder; tablets of 0.25 and 0.5 g per pack of 10 pieces.

Storage: List B. In a well-closed container.