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Description of the medicine: Sulfazin (Sulfazinum)

SULFAZINE (Sulfazinum). 2- (p-Aminobenzenesulfamido) -pyrimidine.

Synonyms: Adiazin, Debenal, Pirimal, Pyrimal, Sulfadiazin, Sulfadiazinum, Sulfapyrimidin, Ultradiazin and others.

White or white with a yellowish tinge crystalline powder odorless. Virtually nerastvorim in water, very slightly soluble in alcohol, soluble in hydrochloric acid and alkali solutions.

Sulfasin is less bound by plasma proteins and is more slowly excreted from the body than norsulfazole, which provides a higher concentration of sulfasin in the blood and organs.

Indications for use are the same as for norsulfazole.

Assign inside. Adults on the first dose give 2 g (for severe infections up to 4 g), then, for 1 to 2 days, 1 g every 4 hours, and then 1 g every 6 to 8 hours. The treatment is carried out until the body temperature normalizes And the next 3 days.

Children are given 0.1 g / kg for the first time, then 0.025 g / kg (25 mg / kg) every 4 to 6 h.

In dysentery appoint the same as sulfadimezin (cm).

Sulfazin is often used together with other sulfanilamide preparations. In combination with antimalarial drugs (quinine, chloride, etc.), sulfazine is used in the treatment of drug-resistant forms of malaria. Sulfasin is active against asexual erythrocyte stages of malarial plasmodium. As an antimalarial agent, sulfazine (like other sulfanilamide preparations) is relatively inactive, the plasmodium resistance is rapidly developing. However, when taking sulfazine in combination with the main antimalarial drugs, the development of drug resistance slows down and the antimalarial effect is mutually reinforced.

Sulfasin relatively rarely causes nausea and vomiting, as well as changes in the hematopoietic system. Sometimes hematuria, oliguria, anuria are observed.

In the treatment of sulfasin it is necessary to maintain a strong diuresis, an abundant alkaline drink can prevent the development of impaired renal function.

Form release: powder; Tablets of 0.5 g.

Storage: List B. In the dark place.
6. SULFUSINE SILVER SALT (Sulfazini argenti).

White with a creamy shade of fine crystalline powder.

It differs from other sulfanilamide preparations by the presence of silver in the molecule, which strengthens its local antimicrobial - bactericidal - action.

When topically applied as an ointment on the wound surfaces, gradual release of silver ions occurs, which ensures a long-term effect of the drug.

It is used as a 1% ointment called ointment << Sulfargin >> (Ugnuentum <Sulfarginum>). Homogeneous ointment white or white with a creamy shade of color, with a characteristic odor.

Assign ointment <Sulfargin> to adults and children over 3 months for the prevention and treatment of purulent wounds and burns, trophic ulcers, pressure sores.