Description of the medicine: Sulfazin (Sulfazinum)
SULFAZIN (Sulfazinum). 2- (para-Aminobenzenesulfamido) -pyrimidine.
Synonyms: Adiazin, Debenal, Pirimal, Pyrimal, Sulfadiazin, Sulfadiazinum, Sulfapyrimidin, Ultradiazin, etc.
Odorless crystalline powder, white or yellowish. It is practically insoluble in water, very slightly soluble in alcohol, soluble in hydrochloric acid and alkali solutions.
Sulfazine is less bound by plasma proteins and is more slowly excreted from the body than norsulfazole, which provides a higher concentration of sulfazine in the blood and organs.
Indications for use are the same as for norsulfazole.
Assign inside. Adults are given 2 g at the first dose (for severe infections up to 4 g), then, for 1 to 2 days, 1 g every 4 hours, and then 1 g every 6 to 8 hours. Treatment is carried out until the body temperature normalizes and in the next 3 days.
Children are given 0.1 g / kg at the first dose, then 0.025 g / kg (25 mg / kg) every 4 to 6 hours.
With dysentery, it is prescribed in the same way as sulfadimezin (cm).
Sulfazine is often used in conjunction with other sulfa drugs. In combination with antimalarial drugs (quinine, chloridine, etc.), sulfazine is used in the treatment of drug-resistant forms of malaria. Sulfazine is active against asexual erythrocyte stages of malarial plasmodium. As an antimalarial drug, sulfazine (like other sulfanilamide drugs) is relatively low in activity; plasmodium resistance develops rapidly to it. However, when taking sulfazine in combination with the main antimalarial drugs, the development of drug resistance slows down and the antimalarial effect is mutually enhanced.
Sulfazine relatively rarely causes nausea and vomiting, as well as changes in the hematopoietic system. Sometimes hematuria, oliguria, anuria are observed.
In the treatment with sulfazine, it is necessary to maintain enhanced diuresis, heavy alkaline drink can prevent the development of impaired renal function.
Method of release: powder; 0.5 g tablets
Storage: List B. In the dark place.
6. SULFAZINA SILVER SALT (Sulfazini argenti).
Fine crystalline white with a creamy tint.
It differs from other sulfanilamide preparations by the presence of a silver atom in the molecule, which enhances its local antimicrobial - bactericidal - effect.
When applied topically in the form of an ointment to wound surfaces, a gradual release of silver ions occurs, which ensures the long-term effect of the drug.
It is used as a 1% ointment called ointment << Sulfargin >> (Ugnuentum <Sulfarginum>). A homogeneous ointment of a white or creamy-white color with a characteristic odor.
Prescribe ointment <Sulfargin> locally for adults and children older than 3 months for the prevention and treatment of purulent wounds and burns, trophic ulcers, bedsores.