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Medication Description: Sulfazin (Sulfazinum)

SULFAZINE (Sulfazinum). 2- (para-aminobenzenesulfamido) -pyrimidine.

Synonyms: Adiazin, Debenal, Pirimal, Pyrimal, Sulfadiazin, Sulfadiazinum, Sulfapyrimidin, Ultradiazin, etc.

White or white with a yellowish sheen odorless crystalline powder. Practically insoluble in water, very slightly soluble in alcohol, soluble in hydrochloric acid and alkali solutions.

Sulfazin is less bound to plasma proteins and is secreted more slowly from the body than norsulfazole, which provides a higher concentration of sulfazin in the blood and organs.

Indications for use are the same as for norsulfazol.

Assign inside. Adults on the first admission give 2 g (with severe infections up to 4 g), then, for 1 to 2 days, 1 g every 4 hours, and then 1 g every 6 to 8 hours. The treatment is carried out until the body temperature normalizes. and in the next 3 days.

Children are given 0.1 g / kg at the first dose, then by 0.025 g / kg (25 mg / kg) every 4-6 hours.

When dysentery is prescribed the same way as sulfadimezin (cm).

Sulfazin is often used together with other sulfa drugs. In combination with antimalarials (quinine, chloridine, etc.), sulfazine is used in the treatment of drug-resistant forms of malaria. Sulfazine is active against asexual erythrocyte stages of malaria plasmodium. As an antimalarial agent, sulfazin (like other sulfa drugs) is relatively little active, and resistance to plasmodia is rapidly developing. However, when taking sulfazin in combination with the main antimalarial drugs, the development of drug resistance slows down and mutually reinforces the antimalarial effect.

Sulfazine relatively rarely causes nausea and vomiting, as well as changes in the hematopoietic system. Sometimes hematuria, oliguria, anuria are observed.

In the treatment with sulfazin, it is necessary to maintain enhanced diuresis, abundant alkaline drinking can prevent the development of renal dysfunction.

Method of issuance: powder; tablets of 0.5 g.

Storage: List B. In the dark spot.
6. SULFAZINE SILVER SALT (Sulfazini argenti).

White with a creamy shade fine crystalline powder.

It differs from other sulfa drugs by the presence of a silver atom in the molecule, which enhances its local antimicrobial - bactericidal - action.

When applied topically as an ointment on the wound surfaces, there is a gradual release of silver ions, which ensures a long-lasting effect of the drug.

It is used as a 1% ointment called << Sulfargin >> ointment (Ugnuentum <Sulfarginum>). A uniform ointment of white or white with a creamy shade of color, with a characteristic odor.

Assign ointment <Sulfargin> topically to adults and children over 3 months for the prevention and treatment of purulent wounds and burns, trophic ulcers, bedsores.