Medication Description: Sulfadimezin (Sulfadimezinum)
SULFADIMEZIN (Sulfadimezinum). 2- (para-aminobenzenesulfamido) - 4, 6 - dimethylpyrimidine.
Synonyms: Diazil, Diazol, Dimethazil, Dimethyldebenal, Dimethylsulphadiazine, Dimethylsulphapyrimidine, Pirmazin, Sulfadimerazine, Sulfadzem, Zulfat, Sulfat, Ltd., Sulfadzine, Sulfadzid, Zimethin, Dimethazil, Dimethazil, Dimethazil
White or slightly yellow crystalline powder. Practically insoluble in water, easily soluble in acids and alkalis.
Applied with pneumococcal, streptococcal, meningococcal infections, sepsis, gonorrhea, as well as infections caused by E. coli and other microorganisms.
Sulfadimezin is rapidly absorbed, relatively low toxic.
Doses for adults are the same as doses of norsulfazole.
The highest dose for adults inside a single 2 g daily 7 g.
Children are prescribed 0.1 g / kg at the first dose, then 0.025 g / kg every 4–6–8 h.
In the treatment of dysentery, sulfadimezin is prescribed to adults according to the following scheme: on the 1st and 2nd days of the disease, 6 g per day (every 4 hours, 1 g); in the 3rd and 4th days - 4 g per day (every 6 hours, 1 g); on the 5th and 6th days, 3 g per day (every 8 hours, 1 g). In the course of treatment from 25 to 30 g of the drug. After a break of 5 to 6 days, the second treatment cycle is carried out: on the 1st and 2nd days, 1 g is prescribed after 4 hours (at night after 8 hours), only 5 g per day; in the 3rd and 4th days - 1 g every 4 hours (do not give at night), only 4 g per day; on the 5th day - 1 g after 4 hours (do not give at night), only 3 g per day. During the entire second cycle, 21 g of the drug is given; with mild disease, the dose can be reduced to 18 g.
Children sulfadimezin prescribed for dysentery in the following doses up to 3 years - up to 0.2 g / kg per day; The daily dose is divided into 4 doses and given during the day, without disturbing the night’s sleep. In this dose, the drug is taken within 7 days. Children older than 3 years are prescribed 4 times a day in a single dose of 0.4 to 0.75 g, depending on age.
Sulfadimine, like other sulfa drugs, is often used together with antibiotics.
In combination with chloridine, sulfadimezin is used in toxoplasmosis.
In the treatment of sulfadimezinom prescribed abundant alkaline drink. It is necessary to systematically conduct a blood test, as in the treatment of other sulfa drugs.
Method of issuance: powder; tablets of 0.25 and 0.5 g per pack of 10 pieces.
Storage: List B. In a well-closed container, protected from light.