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Description of drug: Sulfapyridazine (Sulfapyridazinum)

SULFAPIRIDAZIN (Sulfapyridazinum). 6- (p-Aminobenzenesulfamido) -3-methoxypyridazine.

Synonyms: Kvinoseptil, Kinex, Spofadazin, Sulamin, Altezol, Aseptilex, Davosin, Deposulfal , Depotsulfamid K, Depovernill, Durasulf, Kynex, Lederkyn, Lentosulfa, Lidazin, Longamid, Longisulf, Midicel, Midikel, Myasulf, Neosulfon, Novosulfin, Pirasulfon, Qilnoseptyl , Retasulfin, Spofadazin, Sulamin, Sulfadazina, Sulfadurazin, Sulfalex, Sulfamethopyrazine, Sulfamethoxypyridazine, Sulfamethoxypyridazinum, Sulfurene, Sulphamethoxypiridazin et al.

White or white with a slightly yellowish tinge crystalline powder odorless, bitter taste. Almost nerastvorim in water, little - in alcohol, easily - in diluted acids and alkalis.

Sulfapyridazine belongs to the group of long-acting sulfanilamide preparations. The drug is rapidly absorbed from the gastrointestinal tract and penetrates into various organs and tissues. After a single dose in a dose of 1 g, the therapeutic concentration in the blood is created after 1 hour and remains for a day. The maximum concentration (8 - 10 mg) was observed through W -. 6 hours Introduction maintenance dose (0.5 g) 1 time per day for 7 - 10 days provides therapeutic concentrations in the blood during the course of treatment.

The slow removal of sulfapiridazine from the body largely depends on the reabsorption of the drug in the renal tubules, and also on its ability to bind intensely with plasma proteins (albumins). The drug associated with the protein does not have an antibacterial effect, the activity manifests itself with the release of sulfapiridazine from the complex with proteins.

Sulfur pyridazine is excreted in urine in unchanged form (ZO - 60%) and in acetylated form (40-70% of the dose taken). When the renal function is impaired, the release of the drug is dramatically slowed.

The drug is effective against gram-positive (pneumococcus, streptococcus, enterococcus, staphylococcus) and gram-negative (intestinal and dysentery bacillus, certain strains of the protein, gonococcus, meningococcus) bacteria, highly active against the trachoma virus, affects some protozoa (toxoplasma, plasmodium malaria). It does not affect bacteria resistant to other sulfanilamide preparations.

Sulfapyridazine is used to treat pneumonia, bronchitis, tonsillitis, pharyngitis, purulent otitis, purulent infections of the urogenital tract, dysentery, enterocolitis, bile duct infections, purulent meningitis (especially meningococcal and pneumococcal), for the prevention and treatment of purulent surgical infections. If necessary, also used to prevent bacterial infections in viral diseases of the upper respiratory tract. Patients with trachoma appoint sulfapiridazin and sulfapiridazin-sodium.

Assign sulfapiridazin inside (in tablets). The daily dose is given in a single dose (with intervals between regular doses of 24 hours). The first day is prescribed for adults, depending on the severity of the disease 1 - 2 g. The next day give 0.5 or 1 g and spend the whole course of treatment on this maintenance dose.

The average duration of treatment is 5 to 7 days. After normalization of body temperature continue to give the drug for 2 - 3 days.