Medication Description: Sulfapyridazinum (Sulfapyridazinum)
SULFAPIRIDAZIN (Sulfapyridazinum). 6- (p-Aminobenzene sulphamido) -3-methoxypyridazine.
Synonyms: Quinoseptic, Kinex, Spofadazin, Sulamine, Altezol, Aseptilex, Davosin, Deposulfal, Depotsulfamid K, Depovernill, Durasulf, Kynex, Lederkyn, Lentosulfa, Lidazin, Longamid, Longisulf, Midicel, Midi , Retasulfin, Spofadazin, Sulamin, Sulfadazina, Sulfadurazin, Sulfalex, Sulfamethopyrazine, Sulfamethoxypyridazine, Sulfamethoxypyridazinum, Sulfurene, Sulphamethoxypiridazin and others.
White or white with a slightly yellowish white crystalline powder; odorless, bitter taste. Practically insoluble in water, low in alcohol, lightly in diluted acids and alkalis.
Sulfapyridazin belongs to the group of long-acting sulfanilamide drugs. The drug is rapidly absorbed from the gastrointestinal tract and penetrates into various organs and tissues. After a single dose of the drug in a dose of 1 g, the therapeutic concentration in the blood is created already after 1 h and lasts for a day. The maximum concentration (8–10 mg) is observed after 3–6 hours. The introduction of a maintenance dose (0.5 g) 1 time per day for 7–10 days provides a therapeutic concentration in the blood during the course of treatment.
Slow elimination of sulfapyridazine from the body largely depends on the reabsorption of the drug in the renal tubules, as well as on its ability to bind intensively with plasma proteins (albumin). The drug bound to the protein does not have an antibacterial effect, the activity is manifested as the release of sulfapyridazine from the complex with proteins.
Sulfapyridazine is excreted in the urine in unchanged form (30%) and in the acetylated form (40-70% of the dose taken). When kidney function is abnormal, the release of the drug slows dramatically.
The drug is effective against Gram-positive (pneumococci, streptococci, Enterococci, Staphylococci) and Gram-negative (Escherichia coli and dysentery, some strains of Proteus, gonococcus, meningococcus) bacteria is highly active against the virus of trachoma, acts on certain protozoa (Toxoplasma, Plasmodium malaria). Does not act on bacteria resistant to other sulfanilamide preparations.
Sulfapyridazine is used to treat pneumonia, bronchitis, tonsillitis, pharyngitis, purulent otitis, purulent infections of the urinary tract, dysentery, enterocolitis, biliary tract infections, purulent meningitis (primarily meningococcal and pneumococcal), for the prevention and treatment of purulent surgical infections. If necessary, also used for the prevention of bacterial infections in viral diseases of the upper respiratory tract. Patients with trachoma appoint sulfapyridazin and sulfapyridazin-sodium.
Assign sulfapiridazin inside (in tablets). The daily dose is given in one step (with intervals between successive doses of 24 hours). On the 1st day, adults are prescribed, depending on the severity of the disease, 1 - 2 g. The next day, 0.5 or 1 g is given and the whole course of treatment is carried out on this maintenance dose.
The average duration of treatment is 5-7 days. After normalization of body temperature, continue to give the drug for 2 to 3 days.