Description of the medicine: Sulfapyridazine (Sulfapyridazinum)
SULFAPYRIDAZINE (Sulfapyridazinum). 6- (para-Aminobenzenesulfamido) -3-methoxypyridazine.
Synonyms: Quinoseptil, Kinex, Spofadazin, Sulamine, Altezol, Aseptilex, Davosin, Deposulfal, Depotsulfamid K, Depovernill, Durasulf, Kynex, Lederkyn, Lentosulfa, Lidazin, Longamid, Longisulf, Midicel, Midikelon, Myasulfon, Myikulfon, Myasulfon , Retasulfin, Spofadazin, Sulamin, Sulfadazina, Sulfadurazin, Sulfalex, Sulfamethopyrazine, Sulfamethoxypyridazine, Sulfamethoxypyridazinum, Sulfurene, Sulfamethoxypiridazin, etc.
Flavourless, white or white with a slightly yellowish tint, crystalline powder, bitter in taste. It is practically insoluble in water, little in alcohol, slightly in diluted acids and alkalis.
Sulfapyridazine belongs to the group of long-acting sulfonamide drugs. The drug is rapidly absorbed from the gastrointestinal tract and penetrates into various organs and tissues. After a single dose of the drug in a dose of 1 g, a therapeutic concentration in the blood is created after 1 h and persists for a day. The maximum concentration (8-10 mg) is observed after 3-6 hours. Administration of a maintenance dose (0.5 g) once a day for 7-10 days provides a therapeutic concentration in the blood during the course of treatment.
Slow excretion of sulfapyridazine from the body largely depends on the reabsorption of the drug in the renal tubules, as well as on its ability to intensively bind to plasma proteins (albumin). The drug associated with the protein does not have an antibacterial effect, activity is manifested as sulfapyridazine is released from the complex with proteins.
Sulfapyridazine with urine is excreted unchanged (30% - 30%) and in acetylated form (40 - 70% of the dose taken). In case of impaired renal function, the release of the drug slows down sharply.
The drug is effective against gram-positive (pneumococci, streptococci, enterococci, staphylococci) and gram-negative (Escherichia coli and dysentery bacilli, some strains of Proteus, gonococcus, meningococcus) bacteria, highly active against trachoma virus, acts on some protozoa (toxoplasma, plasma). It does not affect bacteria resistant to other sulfa drugs.
Sulfapyridazine is used to treat pneumonia, bronchitis, tonsillitis, pharyngitis, purulent otitis media, purulent infections of the genitourinary tract, dysentery, enterocolitis, biliary tract infections, purulent meningitis (primarily meningococcal and pneumococcal), for the prevention and treatment of purulent surgical infections. If necessary, they are also used to prevent bacterial infections in viral diseases of the upper respiratory tract. Patients with trachoma are prescribed sulfapyridazine and sodium sulfapyridazine.
Prescribe sulfapyridazine orally (in tablets). The daily dose is given in one dose (with intervals between successive doses of 24 hours). On the 1st day, adults are prescribed, depending on the severity of the disease, 1 - 2 g. The next day, give 0.5 or 1 g and spend the entire course of treatment at this maintenance dose.
The average duration of treatment is 5 to 7 days. After normalization of body temperature continue to give the drug for 2 to 3 days.