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Description medications: piriditol (Pyriditolum)
Piriditol (Pyriditolum).
Bis (2-methyl-3-hydroxy-4-oksimetilpiridil-5-methyl) - disulfide dihydrochloride.
Synonyms: Pyritinol, Enerbol, Encephabol, Biocephalin, Bonifen, Cefalogen, Cervitalin , Cogitan, Dipiridol, Enbol, Encerebrovit, Encefabol, Encefort, Encephabol, Enerbol, Estisol, Neurotin, Neuroxin, Piritinol, Psicobolin, Pyrithioxin, Pyritinol, Tonobrein and others.
White or white with a slightly yellowish white crystalline powder. Easily soluble in water, slightly soluble in alcohol.
The structure differs from piriditol nootropics GABAergic nature. It can be regarded as double molecule pyridoxine (cm.), Containing the disulfide bridge >> << (pyridoxine disulfide).
Pharmacological preparations characterized nootropic activity with a complex spectrum of psychotropic activity. It enhances the effects of amphetamine, however, reduces the spontaneous locomotor activity, prolongs the hypnotic effect of barbiturates, enhances the anticonvulsant effect of phenobarbital. The drug activates metabolic processes in the central nervous system and accelerate the penetration of glucose through the blood-brain barrier and reduces excessive formation of lactic acid, increases resistance to brain tissue hypoxia. There is evidence of a decrease under the influence piriditola of GABA in nerve tissue. B6-vitamin A activity is not.
According to clinical effects piriditol similar to antidepressants, sedative properties, but a combination of its rank as neuroprotective agents.
Piriditol used for combination therapy with shallow depression with symptoms of lethargy in asthenic conditions, weakness, neurosis-like disorders in traumatic and vascular encephalopathy, residual problems after neyroinfektsy and cerebrovascular events, in cerebral atherosclerosis, migraine. Children are used in delayed mental development, tserebrastenicheskom syndrome, mental retardation, encephalopathy.
Take piriditol inside (15 - 30 min after a meal) 2 - 3 times a day. Single dose for adults 0.1 - 0.3 g; for children - 0.05 - 0.1 g; daily adult dose of 0.2 to 0.6 g (typically 0.3 - 0.4 g), for children - 0.05 - 0.3 In the first 10 days of a drug administered at a lower dose (adult 0 3 - 0.4 g per day), then, if necessary, good tolerability, dose increased. The course of treatment is continuing in adults 1 - 3 months (6 - 8 months) in children 2 weeks to 3 months. Repeated treatments for adults after 1 - 6 month break, children 3 - 6 months.
When using piriditola possible headache, nausea, insomnia, irritability, in children - psychomotor agitation, sleep disturbance. In these cases, the dose is reduced. The drug is not recommended in the evening hours.
Contraindicated in patients with severe psychomotor agitation, epilepsy, increased convulsive readiness.
Method of production: tablets of 0.05; 0.1 and 0.2 g-coated yellow, in a package of 60 pieces.
Storage: in a dry dark place.
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