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Description of the medicine: Pyriditol (Pyriditolum)

Pyriditolum (Pyriditolum).

Bis- (2-methyl-3-hydroxy-4-hydroxymethylpyridyl-5-methyl) - disulfide dihydrochloride.

Synonyms: Pyritinol, Enerbol, Encephabol, Biocephalin, Bonifen, Cefalogen, Cervitalin, Cogitan, Dipiridol, Enbol, Encerebrovit, Encefabol, Encefort, Encephabol, Enerbol, Estisol, Pyritin, Neurotin, Neuroxin, Piritinolite, Pyiritin Pyritolin, Pyiritin, Pyiritin, Pyiritin, Pyiritin, Pyiritol

Crystalline powder, white or white with a slightly yellowish tint. Easily soluble in water, slightly soluble in alcohol.

Pyriditol differs in structure from nootropic preparations of GABAergic nature. It can be considered as a doubled pyridoxine molecule (see), containing a disulfide "bridge" (pyridoxine disulfide).

Pharmacologically, the drug is characterized by nootropic activity with a complex spectrum of psychotropic activity. It enhances the effects of phenamine, while reducing spontaneous locomotor activity, prolongs the hypnotic effect of barbiturates, and enhances the anticonvulsant effect of phenobarbital. The drug activates metabolic processes in the central nervous system, helps to accelerate the penetration of glucose through the blood-brain barrier, reduces the excessive formation of lactic acid, increases the resistance of brain tissue to hypoxia. There is evidence of a decrease in the content of GABA in the nervous tissue under the influence of pyriditol. In 6-vitamin activity does not possess.

According to the clinical effects, pyriditol is similar to antidepressants with sedative properties, but in terms of the combination of actions it is classified as nootropic drugs.

Pyriditol is used for complex therapy for shallow depression with lethargy in asthenic conditions, adynamia, neurosis-like disorders, traumatic and vascular encephalopathy, residual effects after neuroinfection and cerebrovascular accident, cerebral atherosclerosis, and migraine. In children, they are used for mental retardation, cerebrosthenic syndrome, oligophrenia, encephalopathy.

Pyriditol is taken orally (15-30 minutes after eating) 2 to 3 times a day. Single dose for adults 0.1 - 0.3 g; for children - 0.05 - 0.1 g; the daily dose for adults is from 0.2 to 0.6 g (usually 0.3 - 0.4 g), for children - 0.05 - 0.3 g. In the first 10 days, the drug is prescribed in a lower dose (adults 0, 3 - 0.4 g per day), then, if necessary and with good tolerance, the dose is increased. The course of treatment continues in adults 1 to 3 months (up to 6 to 8 months), in children from 2 weeks to 3 months. Repeated courses of treatment are carried out in adults after 1 - 6 months of break, in children after 3 - 6 months.

When using pyriditol, headache, nausea, insomnia, irritability are possible, in children - psychomotor agitation, sleep disturbance. In these cases, the dose is reduced. The drug is not recommended to be taken in the evening.

Contraindicated in severe psychomotor agitation, epilepsy, increased convulsive readiness.

Method of release: tablets at 0.05; 0.1 and 0.2 g, coated with a yellow shell, in a package of 60 pieces.

Storage: in a dry, dark place.