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Medication Description: Sulfadimethoxine (Sulfadimethoxinum)

SULFADIMETOKSIN (Sulfadimethoxinum). 4 - (pair - Aminobenzene sulfamido) -2, 6-dimethoxypyrimidine.

Synonyms: Deposul, Madribon, Madroxin, Agribon, Aristin, Deposul, Depot-Sulfamid, Fuxal, Madribon, Madriquid, Madroxine, Sulfadimethoxine, Sulfastop, Sulxin, Supersulfa, Ultrasulfan, Wysulfa, etc.

White or white with a creamy shade of crystalline powder; odorless. Practically insoluble in water, slightly soluble in alcohol, easily in dilute hydrochloric acid and solutions of caustic alkalis.

Refers to the group of long-acting sulfa drugs. On antibacterial action close to sulfapyridazin.

Effective against gram-positive and gram-negative bacteria: acts on pneumococci, streptococci, staphylococci, E. coli, Klebsiella sticks (Friedlander sticks), dysentery pathogens; less active against protea; active against trachoma virus, does not act on bacterial strains resistant to other sulfanilamide preparations.

The drug is relatively slowly absorbed from the gastrointestinal tract. After ingestion is detected in the blood after 30 minutes, however, the maximum concentration is reached after 8 to 12 hours. The required therapeutic concentration in the blood (in adults) is noted when taking the drug on day 1 in doses of 1-2 g and 0.5 times each. 1, O g in the following days.

Compared with other long-acting sulfonamides (sulfapyridazine, sulfamonometoksin) sulfadimetoksin worse penetrates the blood-brain barrier, and therefore its use in purulent meningitis is impractical. Other indications for sulfadimethoxine use are the same as for sulfapiridazine (acute respiratory diseases, pneumonia, bronchitis, angina, sinusitis, otitis media, meningitis, dysentery, inflammatory diseases of the biliary and urinary tract, erysipelas, pyoderma, wound infections, trachoma, gonorrhea, etc. .). It is also prescribed in combination with antimalarial drugs (with resistant forms of malaria).

Apply inside (in tablets). The daily dose is given in one step. The intervals between doses of 24 hours. In milder forms of the disease, 1 g is prescribed on the 1st day, and 0.5 g on the following days; with moderate forms, respectively 2 g and 1 g. Children should be prescribed 25 mg / kg on the 1st day and 12, 5 mg / kg on the following days. In severe forms of diseases, sulfadimethoxine is recommended to be used in combination with antibiotics (penicillin groups, erythromycin, etc.) or to prescribe other long-acting sulfonamides.

Possible complications and contraindications are the same as with the use of sulfapyridazin.

Method of issuance: powder; tablets of 0.2 and 0.5 g per pack of 10 pieces.

Storage: List B. In the dark spot.

Sulfadimethoxine is included in the ointment << Levocin >> (see Levomycetin).