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Description of the medicine: Sulfadimethoxin (Sulfadimethoxinum)

SULFADIMETOXIN (Sulfadimethoxinum). 4 - (para - Aminobenzenesulfamido) -2, 6-dimethoxypyrimidine.

Synonyms: Deposul, Madribon, Madroxin, Agribon, Aristin, Deposul, Depot-Sulfamid, Fuxal, Madribon, Madriquid, Madroxine, Sulfadimethoxine, Sulfastop, Sulxin, Supersulfa, Ultrasulfan, Wysulfa, etc.

Flavourless crystalline powder, white or creamy white. It is practically insoluble in water, slightly soluble in alcohol, easily in dilute hydrochloric acid and caustic alkali solutions.

Belongs to the group of long-acting sulfonamide drugs. It has an antibacterial effect similar to sulfapyridazine.

Effective against gram-positive and gram-negative bacteria: acts on pneumococci, streptococci, staphylococci, E. coli, Klebsiella bacillus (Friedlander’s bacillus), dysentery pathogens; less active against protea; active against trachoma virus, does not affect bacterial strains resistant to other sulfa drugs.

The drug is relatively slowly absorbed from the gastrointestinal tract. After oral administration, it is detected in the blood after 30 minutes, but the maximum concentration is reached after 8 - 12 hours. The necessary therapeutic concentration in the blood (in adults) is observed when taking the drug on the 1st day in doses of 1 - 2 g and 0.5 - 1, About r in the following days.

Compared with other long-acting sulfonamides (sulfapyridazine, sulfamonomethoxine) sulfadimethoxin penetrates the blood-brain barrier worse, and therefore its use in purulent meningitis is impractical. Other indications for the use of sulfadimethoxin are the same as for sulfapyridazine (acute respiratory infections, pneumonia, bronchitis, tonsillitis, sinusitis, otitis media, meningitis, dysentery, inflammatory diseases of the biliary and urinary tract, erysipelas, pyoderma, wound infections, trachoma, gonorrhea, etc. .). It is also prescribed in combination with antimalarial drugs (with resistant forms of malaria).

Apply inside (in tablets). The daily dose is given in one dose. The intervals between doses are 24 hours. For mild forms of the disease, 1 g is prescribed on the 1st day, on the next days, 0.5 g; with moderate forms, respectively, 2 g and 1 g. Children are prescribed 25 mg / kg on the 1st day and 12.5 mg / kg on the following days. In severe forms of the disease, sulfadimethoxin is recommended to be used in combination with antibiotics (penicillin groups, erythromycin, etc.) or to prescribe other long-acting sulfonamides.

Possible complications and contraindications are the same as with sulfapyridazine.

Method of release: powder; tablets of 0.2 and 0.5 g in a package of 10 pieces.

Storage: List B. In the dark place.

Sulfadimethoxin is part of the ointment << Levosin >> (see Chloramphenicol).