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Description medications: Aposulfatrim

Co-trimoxazole (Co-trimoxazolum).

Combined preparation containing two active ingredients: sulfamethoxazole sulfanilamide preparation and diaminopyrimidine derivative - trimethoprim.

Synonyms: Apo-Sulfatrim, Baktekod, Baktoredukt, Bactrim, Berlotsid, Bikotrim, Biseptolum, Bisutrim, Gene Ultrazol, Groseptol, Duo septuplets, intro, Cauterets, Cotrimoxazole, Kotrimol, Kotrifarm, New Trimel, Oribakt, Oriprim, Septrin, Sinersul, Sulotrim, sulfamethoxazole and trimethoprim, Sulfatrim, Sumetrolim, TMS 480, Trim, Trimezol, Trimosul, pline, Ekspozol, Abactin, Abactrim, Andoprim, Aposulfatrim, Apo-Sulfatrim, Bactecod, Bactramin, Bacterial, Bactrimel, Bactrisol, Bacticel, Bactofer , Bactoreduct, Bactrim, Berlocid, Bicotrim, Biseptol, Bisutrim, Chemitrin, Ciplin, Cotrim, Cotrimol, Cotrimoxazol, Cotripharm, Doctonil, Duo-Septol, Ectapprim, Espectrin, Expozol, Falprin, Gantrin, Gen-Ultrazol, Groseptol, Infectrim, Intrim , Metomide, Microcetim, Nolapse, Novo-Trimel, Oradin, Oribact, Oriprim, Potesept, Primazol, Rancotrim, Resprim, Septocid, Septrin, Sinersul, Sulotrim, Sumetrolim, TMS 480, Trim, sulfamethoxazole and Trimethoprim, Trimexazol, Trimezol, Trimosul, Trixazol, Uroxen, Vanadyl and others.

Sulfamethoxazole (Sulfamethoxazolum). 3- (p-Aminobenzolsulfamido) -5-methylisoxazole.

Synonyms: Gantanol, Metoxal, Radonil, Sunomin , Sulfamethoxazole, Sulfamethylisoxazole, Sulfisomezole, Sulphamethoxazole.

It is antibacterial drug, similar in activity with other chemotherapeutic drugs sulfanilamidnymi.

Trimethoprim (Trimethoprimum). 2, 4-Diamino-5- (3, 4, 5-trimethoxybenzyl) -pyrimidine.

Synonyms: Metopicide, Syraprim, Trimethoprim.

According himicheckoy structure similar to hloridin (cm.). It has antibacterial activity.

The combination of these two agents, each of which has a bacteriostatic effect, provides a high bactericidal activity against gram-positive and gram-negative microorganisms, including bacteria resistant to sulfanilamide preparations.

Bactericidal effect associated with the double baktrima blocking action on the metabolism of the bacteria. Sulfamethoxazole violates the biosynthesis of dihydrofolate acid, and trimethoprim blocks metabolism the next stage - the restoration of dihydrofolate acid necessary for microbial growth tetrahydrofolic acid. Selecting sulfamethoxazole as baktrima component due to the fact that it has the same speed with the elimination of trimethoprim.

The drug is available in tablets in two dosages: adult content per tablet of 0.4 g (400 mg) and 0.08 g of sulfamethoxazole (80 mg), trimethoprim; Children with the content in one tablet of 100 mg sulfamethoxazole and 20 mg trimethoprim.

Adults produced as tablets Bactrim Forte << >> containing 800 mg sulfamethoxazole and 160 mg trimethoprim and syrup for children, in which 1 ml contains 40 mg of sulfamethoxazole and trimethoprim 8 mg (suspension white with a yellowish tint in bottles of 100 mL).

The drug is effective against streptococci, staphylococci, pneumococci, bacillus dysentery, typhoid fever, E. coli, Proteus; ineffective against Mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa.

The drug is rapidly absorbed by ingestion. Maximum concentration in the blood observed after 1 - 3 hours after admission and continued for 7 hours, concentrations are high in the lungs and kidneys..