This page has been robot translated, sorry for typos if any. Original content here.

Attention! Information is for reference only!
Before taking, be sure to consult a doctor!
SITE ONLY DIRECTORY. NOT A PHARMACY! We do not sell medicines! None!

Medication Description: Co-trimoxazole (Co-trimoxazolum)

CO-TRIMOXAZOL (Co-trimoxazolum).

The combined drug containing two active ingredients: sulfanilamide drug sulfamethoxazole and a derivative of diaminopyrimidine - trimethoprim.

Synonyms: Apo-Sulfatrim, Baktekod, Bactoreduct, Bactrim, Berlotsid, Bikotrim, Biseptol, Bismuthrim, Gen-Ultrazol, Grosptol, Duo-Septol, Intrim, Cotrimoxazole, Cotrimol, Cotriphroma, Novo-Trimm, Intro, Cotrimol, Cotrimoxazole, Cotrimol, Cotropharm, New Trim, Intro, Cotrimol, Cotrimoxazole, Cotrimol, Cotriphroma, New Trim, Intro, Cotrimol, Cotrimoxazole, Cotrimol, Cotriphroma, Novo-Trim, Intro, Cotrimol, Cotrimoxazole, Cotrimol, Cotropharm, Novo-Trim, Intro, Cotrimol, Cotrimoxazole, Cotrimol, Cotropharm, Novo-Trim, Intro, Cotrimol, Cotrimoxazole, Cotrimol, Cotropharm Sinersul, Sulotrim, Sulfamethoxazole and Trimethoprim, Sulfatrim, Sumetrolim, TMS 480, Trim, Trimesol, Trimosul, Ziplin, Exposol, Abactin, Abactrim, Andoprim, Aposulfatrim, Apo-Sulfatrim, Bactecod, Brystryes , Bactoreduct, Bactrim, Berlocid, Bicotrim, Biseptol, Bisutrim, Chemitrin, Ciplin, Cotrim, Cotrimol, Cotrimoxazol, Cotripharm, Doctonil, Duo-Septol, Ectapprim, Espectrin, Expozol, Falprin, Gantrin, West African, Synthynan-9 im, Intrim, Metomide, Microcetim, Nolapse, Novo-Trimel, Oradin, Oribact, Oriprim, Potesept, Primazol, Rancotrim, Resprim, Septocid, Septrin, Sinersul, Sulotrim, Sumtrolim, TMS 480, Trim, Sulfor temphosehanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshanshit, Shamparam , Trimosul, Trixazol, Uroxen, Vanadyl, etc.

Sulfamethoxazole (Sulfamethoxazolum). 3- (p-Aminobenzene sulphamido) -5-methylisoxazole.

Synonyms: Gantanol, Metoxal, Radonil, Sunomin, Sulfamethoxazole, Sulfamethylisoxazole, Sulfisomezole, Sulphamethoxazole.

It is an antibacterial drug similar in chemotherapeutic activity with other sulfa drugs.

Trimethoprim (Trimethoprimum). 2, 4-diamino-5- (3, 4, 5-trimethoxybenzyl) -pyrimidine.

Synonyms: Metopicide, Syraprim, Trimethoprim.

The chemical structure is close to chloride (see). It has antibacterial activity.

The combination of these two drugs, each of which has a bacteriostatic effect, provides a high bactericidal activity against gram-positive and gram-negative microorganisms, including bacteria resistant to sulfanilamide drugs.

The bactericidal effect is associated with the double blocking effect of bacterium on the metabolism of bacteria. Sulfamethoxazole violates the biosynthesis of dihydrofolic acid, and trimethoprim blocks the next stage of metabolism — the reduction of dihydrofolic acid to tetrahydrofolic acid, which is necessary for the development of microorganisms. The choice of sulfamethoxazole as a component of baktrim is caused by the fact that it has the same rate of elimination with trimethoprim.

The drug is available in tablets in two dosages: for adults with a content of 0.4 g (400 mg) of sulfamethoxazole and 0.08 g (80 mg) of trimethoprim in one tablet; for children with 100 mg sulfamethoxazole and 20 mg trimethoprim in one tablet.

<< Bactrim Forte >> tablets containing 800 mg of sulfamethoxazole and 160 mg of trimethoprim are produced for adults, and a syrup for children, in 1 ml of which contains 40 mg of sulfamethoxazole and 8 mg of trimethoprim (a suspension of white with a yellowish tint in bottles of 100 ml)

The drug is effective against streptococci, staphylococci, pneumococci, dysentery bacilli, typhoid fever, Escherichia coli, Proteus; ineffective against mycobacterium tuberculosis, spirochaetes, pseudomonas aeruginosa.

The drug is rapidly absorbed by ingestion. The maximum concentration in the blood is noted after 1 - 3 hours after administration and lasts for 7 hours. High concentrations are found in the lungs and kidneys.