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Description of the medicine: Co-trimoxazole (Co-trimoxazolum)

CO-TRIMOXAZOZOL (Co-trimoxazolum).

A combined preparation containing two active ingredients: sulfamethoxazole sulfanilamide preparation and trimethoprim derivative diaminopyrimidine.

Synonyms: Apo-Sulfatrim, Bactecode, Bactoreduct, Bactrim, Berlocide, Bikotrim, Biseptol, Bisutrim, Gene-Ultrazole, Groseptol, Duo-Septol, Intrim, Cotrim, Cotrimoxazole, Cotrimol, Cotrifarm, Novo-Trimetrim, Novo-Trimetrim, Novo-Trimel, Sinersul, Sulotrim, Sulfamethoxazole and Trimethoprim, Sulfatrim, Sumetrolim, TMS 480, Trim, Trimezole, Trimosul, Ciplin, Expozol, Abactin, Abactrim, Andoprim, Aposulfatrim, Apo-Sulfatrim, Bactecod, Bactramin, Bactacter, Bactram, Bacterial, Bacterial, Bacterial, Bacterial, Bacterial, Bacterial, Bacterial, Bacterial, Bacterial , Bactoreduct, Bactrim, Berlocid, Bicotrim, Biseptol, Bisutrim, Chemitrin, Ciplin, Cotrim, Cotrimol, Cotrimoxazol, Cotripharm, Doctonil, Duo-Septol, Ectapprim, Espectrin, Expozol, Falprin, Gantrin, Genr Ultra, Genr Ultrapt im, Intrim, Metomide, Microcetim, Nolapse, Novo-Trimel, Oradin, Oribact, Oriprim, Potesept, Primazol, Rancotrim, Resprim, Septocid, Septrin, Sinersul, Sulotrim, Sumetrolim, TMS 480, Trim, Sulfamethoxazole and Trimezolaz , Trimosul, Trixazol, Uroxen, Vanadyl, etc.

Sulfamethoxazole (Sulfamethoxazolum). 3- (para-Aminobenzenesulfamido) -5-methylisoxazole.

Synonyms: Gantanol, Metoxal, Radonil, Sunomin, Sulfamethoxazole, Sulfamethylisoxazole, Sulfisomezole, Sulphamethoxazole.

It is an antibacterial drug similar in chemotherapeutic activity to other sulfa drugs.

Trimethoprim (Trimethoprimum). 2, 4-Diamino-5- (3, 4, 5-trimethoxybenzyl) pyrimidine.

Synonyms: Metopicide, Syraprim, Trimethoprim.

The chemical structure is close to chloridine (see). It has antibacterial activity.

The combination of these two drugs, each of which has a bacteriostatic effect, provides high bactericidal activity against gram-positive and gram-negative microorganisms, including bacteria resistant to sulfonamide drugs.

The bactericidal effect is associated with the double blocking effect of bactrim on bacterial metabolism. Sulfamethoxazole disrupts the biosynthesis of dihydrofolic acid, and trimethoprim blocks the next stage of metabolism - the restoration of dihydrofolic acid into tetrahydrofolic acid, which is necessary for the development of microorganisms. The choice of sulfamethoxazole as a component of bactrim is due to the fact that it has the same elimination rate with trimethoprim.

The drug is available in tablets in two dosages: for adults with 0.4 g (400 mg) sulfamethoxazole and 0.08 g (80 mg) trimethoprim in one tablet; for children with 100 mg sulfamethoxazole and 20 mg trimethoprim in one tablet.

For adults, tablets are also produced << Bactrim forte >> tablets containing 800 mg of sulfamethoxazole and 160 mg of trimethoprim, and for children syrup, 1 ml of which contains 40 mg of sulfamethoxazole and 8 mg of trimethoprim (suspension of white with a yellowish tint in 100 bottles ml).

The drug is effective against streptococci, staphylococci, pneumococci, coli dysentery, typhoid fever, Escherichia coli, Proteus; ineffective against mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa.

The drug is rapidly absorbed when taken orally. The maximum concentration in the blood is observed 1 to 3 hours after ingestion and remains for 7 hours. High concentrations are created in the lungs and kidneys.