Description of the medicine: Phthalazole (Phthalazolum)

Phthalazolum (Phthalazolum). 2- (p-Phthalylaminobenzenesulfonamido) -thiazole.

Synonyms: Phthalylsulfathiazole, Phthalylsulfathiazolum, Sulfathalidine, Taleudron, Talidine, Talisulfazol, Thalazol, Thalazone, Thalistatyl.

White or white with a slightly yellowish tinge powder. Almost nerastvorim in water, very little soluble in alcohol. Soluble in an aqueous solution of sodium carbonate.

Phthalazol is slowly absorbed from the gastrointestinal tract. The bulk of the drug, when administered orally, is retained in the intestine, where the active (sulfanilamide) part of the molecule is gradually cleaved off. The high concentration of sulfanilamide in the intestine, combined with the activity of the drug against the intestinal flora, is explained by its greater effectiveness in intestinal infections.

Phthalazole is low in toxicity; Side effects usually do not cause. By action is similar to sulgin.

Applied with dysentery (acute and chronic in the stage of exacerbation), colitis, gastroenteritis, as well as with surgical interventions on the intestine to prevent purulent complications.

In acute form of dysentery, adults are prescribed by mouth on day 1 - 2 for 6 g per day (every 4 hours for 1 g), on days 3 to 4 - 4 grams per day (every 6 hours for 1 g) , In 5 - 6th day - 3 g per day (every 8 hours for 1 g). The course of treatment is only 25 - 30 g.

After the first cycle of treatment (after 5 to 6 days) the second cycle is carried out: 1 - 2-day - 1 g every 4 hours (at night after 8 hours), 5 g per day, 3 - 4-day - 1 G after 4 hours (at night do not give), only 4 g per day; 5th day - 1 g in 4 hours (at night do not give), only 3 grams per day. During the second cycle, a total dose of 21 g; With mild disease, the dose for the second cycle can be reduced to 18 g.

Higher doses for adults are intravenous (2 g, daily 7 g).

Children phthalazole is prescribed in smaller doses: up to 3 years - up to 0.2 g / kg per day; The daily dose is given in three equal portions throughout the day, without disturbing the night sleep. In this dose, the drug is given for 7 days. Children over 3 years of age are prescribed 0.4-0.75 g (depending on age) for admission 4 times a day.

In the treatment of other infections, phthalazole is prescribed to adults in the first 2 to 3 days for 1 to 2 g every 4 to 6 hours, in the next 2 to 3 days, half the dose.

Children are prescribed on the first day of 0.1 g / kg per day. The drug is given in equal doses every 4 hours with a break at night. The following days give 0.2-0.5 g every 6-8 hours.

Treatment with phthalazole, if necessary, combined with the appointment of antibiotics.

It is advisable, simultaneously with phthalazole, to prescribe well-absorbed sulfanilamide preparations (sulfadimezin, etazol, etazol-sodium, etc.).

Form release: powder; Tablets of 0.5 grams in a package of 10 pieces.

Storage: List B. In a well ukuporennoy container.